Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.039 | 0.039 |
Echinococcus multilocularis | hexokinase | 0.0566 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0386 | 0.6691 | 0.6691 |
Entamoeba histolytica | hexokinase 1 | 0.0566 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1385 | 0.1385 |
Loa Loa (eye worm) | hexokinase | 0.0355 | 0.6121 | 0.6121 |
Onchocerca volvulus | 0.0566 | 1 | 1 | |
Plasmodium falciparum | hexokinase | 0.0566 | 1 | 0.5 |
Onchocerca volvulus | 0.0566 | 1 | 1 | |
Trypanosoma cruzi | hexokinase, putative | 0.0566 | 1 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0112 | 0.1657 | 0.1657 |
Entamoeba histolytica | hexokinase 2 | 0.0566 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0566 | 1 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0033 | 0.019 | 0.019 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0112 | 0.1657 | 0.1657 |
Trypanosoma brucei | hexokinase | 0.0566 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0566 | 1 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0033 | 0.019 | 0.019 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.2901 | 0.2901 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.039 | 0.039 |
Echinococcus granulosus | hexokinase | 0.0566 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0105 | 0.1521 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.039 | 0.039 |
Loa Loa (eye worm) | hexokinase type II | 0.0566 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0566 | 1 | 0.5 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0033 | 0.019 | 0.019 |
Echinococcus granulosus | hexokinase | 0.0566 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0566 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.2901 | 0.2901 |
Echinococcus multilocularis | hexokinase | 0.0566 | 1 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.0566 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0112 | 0.1657 | 0.1657 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0123 | 0.1847 | 0.1847 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.039 | 0.039 |
Plasmodium vivax | hexokinase, putative | 0.0566 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0566 | 1 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0566 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0175 | 0.2812 | 0.2812 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0033 | 0.019 | 0.019 |
Schistosoma mansoni | hexokinase | 0.0566 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0033 | 0.019 | 0.019 |
Echinococcus granulosus | voltage gated potassium channel | 0.0033 | 0.019 | 0.019 |
Onchocerca volvulus | 0.0566 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.019 | 0.019 |
Brugia malayi | Hexokinase family protein | 0.0175 | 0.2812 | 0.2812 |
Leishmania major | hexokinase, putative | 0.0566 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0566 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0566 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0123 | 0.1847 | 0.1847 |
Brugia malayi | Hexokinase family protein | 0.0355 | 0.6121 | 0.6121 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.034 | 0.5851 | 0.5851 |
Loa Loa (eye worm) | hexokinase | 0.0566 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0112 | 0.1657 | 0.1657 |
Trypanosoma brucei | hexokinase, putative | 0.0566 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0566 | 1 | 1 |
Brugia malayi | hexokinase type II | 0.018 | 0.2901 | 0.2901 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0105 | 0.1521 | 1 |
Leishmania major | hexokinase, putative | 0.0566 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.039 | 0.039 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0033 | 0.019 | 0.019 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.3078 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.