Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Pseudomonas aeruginosa (strain LESB58) | PvdQ | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3403 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3403 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0912 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0912 | 0.5 |
Mycobacterium ulcerans | manganese transport protein MntH | 0.0052 | 0.194 | 0.194 |
Plasmodium falciparum | transporter, putative | 0.0052 | 0.194 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3403 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0912 | 0.5 |
Onchocerca volvulus | Protein Malvolio homolog | 0.0052 | 0.194 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3403 | 1 |
Brugia malayi | NRAMP-like transporter K11G12.4 | 0.0052 | 0.194 | 0.472 |
Plasmodium vivax | metal transporter, putative | 0.0052 | 0.194 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3403 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3403 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3403 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0632 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3403 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0186 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3403 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.194 | 0.472 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0632 | 0.5 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.0052 | 0.194 | 0.4126 |
Echinococcus granulosus | divalent metal transporter DMT1B | 0.0052 | 0.194 | 0.4126 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0632 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3403 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3403 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0186 | 1 | 1 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.0052 | 0.194 | 0.4126 |
Toxoplasma gondii | divalent metal transporter, putative | 0.0052 | 0.194 | 1 |
Echinococcus multilocularis | divalent metal transporter DMT1B | 0.0052 | 0.194 | 0.4126 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3403 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.194 | 0.472 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0632 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3403 | 1 |
Mycobacterium leprae | DIVALENT CATION-TRANSPORT INTEGRAL MEMBRANE PROTEIN MNTH (BRAMP) (MRAMP) | 0.0032 | 0.0741 | 0.0741 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0912 | 0.5 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0912 | 0.101 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (binding) | = 2.683 uM | PUBCHEM_BIOASSAY: Fluorescent Biochemical Primary HTS to Identify Inhibitors of P. aeruginosa PvdQ acylase Measured in Biochemical System Using Plate Reader and Imaging Combination - 2091-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488968] | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.