Detailed information for compound 1529807
Basic information
Technical information
- Name: Unnamed compound
- MW: 411.43 | Formula: C17H21N3O7S
-
H donors: 0
H acceptors: 5
LogP: 1.75
Rotable bonds: 11
Rule of 5 violations (Lipinski): 1 - SMILES: CCOC(=O)N1CCN(CC1)C(=O)COC(=O)CSc1ccc(cc1)[N+](=O)[O-]
- InChi: 1S/C17H21N3O7S/c1-2-26-17(23)19-9-7-18(8-10-19)15(21)11-27-16(22)12-28-14-5-3-13(4-6-14)20(24)25/h3-6H,2,7-12H2,1H3
- InChiKey: FUSXZPBBINYMTF-UHFFFAOYSA-N
Network
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Synonyms
No synonyms found for this compound
Targets
Known targets for this compound
No curated genes were found associated with this compound
Predicted pathogen targets for this compound
By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Echinococcus granulosus | divalent metal transporter DMT1B | 0.0597 | 1 | 0.5 |
| Mycobacterium ulcerans | divalent cation-transport integral membrane protein | 0.0228 | 0.089 | 0.089 |
| Toxoplasma gondii | divalent metal transporter, putative | 0.0597 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0597 | 1 | 0.5 |
| Mycobacterium leprae | possible membrane transport protein | 0.0228 | 0.089 | 0.2035 |
| Plasmodium vivax | metal transporter, putative | 0.0597 | 1 | 0.5 |
| Onchocerca volvulus | Protein Malvolio homolog | 0.0597 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0597 | 1 | 0.5 |
| Mycobacterium ulcerans | manganese transport protein MntH | 0.0597 | 1 | 1 |
| Mycobacterium tuberculosis | Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) | 0.0369 | 0.4371 | 1 |
| Echinococcus multilocularis | divalent metal transporter DMT1B | 0.0597 | 1 | 0.5 |
| Mycobacterium leprae | DIVALENT CATION-TRANSPORT INTEGRAL MEMBRANE PROTEIN MNTH (BRAMP) (MRAMP) | 0.0369 | 0.4371 | 1 |
| Plasmodium falciparum | transporter, putative | 0.0597 | 1 | 0.5 |
| Schistosoma mansoni | divalent metal transporter DMT1B | 0.0597 | 1 | 0.5 |
| Schistosoma mansoni | divalent metal transporter DMT1B | 0.0597 | 1 | 0.5 |
| Mycobacterium ulcerans | divalent cation-transport integral membrane protein | 0.0228 | 0.089 | 0.089 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
| Potency (functional) | 21.1923 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
| Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Phenotypes
Whole-cell/tissue/organism interactions
| Species name | Source | Reference | Is orphan |
|---|---|---|---|
| Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL1707191
Bibliographic References
No literature references available for this target.
If you have references for this compound, please enter them in a user comment (below) or Contact us.