Detailed information for compound 153042

Basic information

Technical information
  • TDR Targets ID: 153042
  • Name: 1-[1-heptyl-4-(3-hydroxyphenyl)piperidin-4-yl ]propan-1-one
  • MW: 331.492 | Formula: C21H33NO2
  • H donors: 1 H acceptors: 2 LogP: 4.92 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCN1CCC(CC1)(C(=O)CC)c1cccc(c1)O
  • InChi: 1S/C21H33NO2/c1-3-5-6-7-8-14-22-15-12-21(13-16-22,20(24)4-2)18-10-9-11-19(23)17-18/h9-11,17,23H,3-8,12-16H2,1-2H3
  • InChiKey: QYYOWXGHJFPMIM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[1-heptyl-4-(3-hydroxyphenyl)-4-piperidyl]propan-1-one
  • 1-[1-heptyl-4-(3-hydroxyphenyl)-4-piperidinyl]-1-propanone
  • 1-[1-heptyl-4-(3-hydroxyphenyl)-4-piperidinyl]propan-1-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dopamine receptor D3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein dopamine receptor D3 400 aa 392 aa 19.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0047 0.0036
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.019 0.0181
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0312 0.0701
Schistosoma mansoni protein tyrosine phosphatase 0.0049 0.0164 0.0155
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0041 0.0122 0.0113
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Loa Loa (eye worm) oxidoreductase 0.0041 0.0122 0.0122
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0064 0.0055
Mycobacterium tuberculosis Probable oxidoreductase 0.0041 0.0122 0.0274
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0028 0.0019
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0041 0.0122 0.7321
Echinococcus granulosus aldo keto reductase 0.0041 0.0122 0.0113
Echinococcus multilocularis carbonic anhydrase 0.0099 0.0423 0.0414
Brugia malayi ecdysteroid receptor 0.003 0.0064 0.0055
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0064 0.0055
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0092 0.0206
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Schistosoma mansoni carbonic anhydrase-related 0.0099 0.0423 0.0414
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0312 0.0635
Entamoeba histolytica aldose reductase, putative 0.0041 0.0122 0.7321
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.0677 0.0677
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.0677 0.0668
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0043
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0064 0.0055
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0092 0.0092
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Schistosoma mansoni hypothetical protein 0.0047 0.0151 0.0142
Onchocerca volvulus 0.003 0.0064 0.2481
Schistosoma mansoni microtubule-associated protein tau 0.137 0.703 0.7028
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0046 0.0036
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0312 1
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0156 0.0147
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0049 0.0164 0.0155
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0175 0.2404
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0173 0.0388
Trichomonas vaginalis aldo-keto reductase, putative 0.0041 0.0122 0.7321
Brugia malayi hypothetical protein 0.0049 0.0164 0.0155
Leishmania major tyrosine specific protein phosphatase, putative 0.0049 0.0164 0.224
Trypanosoma brucei protein tyrosine phosphatase 1 0.0049 0.0164 0.224
Loa Loa (eye worm) hypothetical protein 0.0035 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0202 0.0958 0.0958
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0041 0.0122 0.0113
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0156 0.0156
Onchocerca volvulus 0.0049 0.0164 1
Onchocerca volvulus 0.0048 0.0156 0.9422
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0175 0.4141
Trichomonas vaginalis aldo/keto reductase, putative 0.0041 0.0122 0.7321
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.019 0.0181
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.0875 0.4457 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0031 0.0022
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0049 0.0164 0.0155
Schistosoma mansoni thyroid hormone receptor 0.003 0.0064 0.0055
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0092 0.0206
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0101 0.0227
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0312 0.7333
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0049 0.0164 0.0155
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0152 0.0699 0.0699
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0092 0.0137
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0031 0.032
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0049 0.0164 0.0155
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0031 0.007
Mycobacterium leprae Probable lipase LipE 0.0035 0.0092 0.0137
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0041 0.0122 0.0206
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0064 0.0055
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Echinococcus multilocularis carbonic anhydrase 0.0099 0.0423 0.0414
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0041 0.0122 0.0113
Mycobacterium tuberculosis Conserved protein 0.0035 0.0092 0.0206
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0173 0.032
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0064 0.0055
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0049 0.0164 0.0155
Schistosoma mansoni hypothetical protein 0.0023 0.0028 0.0019
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Onchocerca volvulus 0.0049 0.0164 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0049 0.0164 0.0155
Loa Loa (eye worm) animal heme peroxidase 0.003 0.0064 0.0064
Onchocerca volvulus 4.1 G protein, putative homolog 0.0049 0.0164 1
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0064 0.2481
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Trichomonas vaginalis aldo-keto reductase, putative 0.0041 0.0122 0.7321
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0234 0.0225
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Schistosoma mansoni metabotropic glutamate receptor 0.0137 0.0622 0.0614
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0064 0.0055
Onchocerca volvulus 0.0049 0.0164 1
Brugia malayi jmjC domain containing protein 0.0061 0.0225 0.0216
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0312 0.0303
Schistosoma mansoni hypothetical protein 0.0027 0.0046 0.0037
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0049 0.0164 0.0155
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0156 0.9422
Echinococcus multilocularis lamin dm0 0.0026 0.0046 0.0036
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0049 0.0164 0.224
Loa Loa (eye worm) animal heme peroxidase 0.003 0.0064 0.0064
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0041 0.0122 0.0113
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0042 0.0126 0.0126
Trichomonas vaginalis aldo/keto reductase, putative 0.0041 0.0122 0.7321
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.019 0.0181
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.019 0.0181
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0064 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0064 0.0055
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0049 0.0164 0.0155
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0041 0.0122 0.0113
Onchocerca volvulus 0.0049 0.0164 1
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0149 0.068 0.0672
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0049 0.0164 0.0155
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1674 0.8608 0.8607
Brugia malayi hypothetical protein 0.0033 0.008 0.0071
Loa Loa (eye worm) hypothetical protein 0.0035 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0225 0.0216
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0099 0.0423 0.0414
Onchocerca volvulus 0.0049 0.0164 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0049 0.0164 0.0155
Onchocerca volvulus Peroxidasin homolog 0.003 0.0064 0.2504
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0064 0.0055
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0049 0.0164 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0064 0.0055
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0064 0.0064
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0009 0.002
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0049 0.0164 0.0155
Onchocerca volvulus 0.0026 0.0046 0.1082
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0041 0.0122 0.0113
Schistosoma mansoni carbonic anhydrase-related 0.0099 0.0423 0.0414
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0312 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0064 0.0055
Schistosoma mansoni hypothetical protein 0.0047 0.0151 0.0142
Entamoeba histolytica aldose reductase, putative 0.0041 0.0122 0.7321
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.0906 0.0898
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Brugia malayi Receptor family ligand binding region containing protein 0.0042 0.0126 0.0117
Loa Loa (eye worm) hypothetical protein 0.0024 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0101 0.0434 0.0434
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0049 0.0164 0.0164
Brugia malayi nuclear hormone receptor 0.003 0.0064 0.0055
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0064 0.2481
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0175 0.2404
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Brugia malayi beta-lactamase 0.0035 0.0092 0.0083
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0049 0.0164 0.0155
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0151 0.0142
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0152 0.0699 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0049 0.0164 0.0155
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0027 0.0046 0.1135
Onchocerca volvulus 0.0049 0.0164 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0173 0.0388
Mycobacterium tuberculosis Conserved protein 0.0035 0.0092 0.0206
Echinococcus granulosus lamin dm0 0.0026 0.0046 0.0036
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0049 0.0164 0.0155
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0049 0.0164 0.0155
Brugia malayi glutathione reductase 0.0037 0.0101 0.0092
Mycobacterium ulcerans beta-lactamase 0.0035 0.0092 0.0206
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0031 0.007
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0031 0.1427
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0041 0.0122 0.0113
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0092 0.0083
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0049 0.0164 1
Brugia malayi hypothetical protein 0.0049 0.0164 0.0155
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0152 0.0699 0.069
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0173 0.0164
Onchocerca volvulus 0.0049 0.0164 1
Loa Loa (eye worm) carbonic anhydrase 3 0.0152 0.0699 0.0699
Trichomonas vaginalis aldo-keto reductase, putative 0.0041 0.0122 0.7321
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0049 0.0164 0.0155
Onchocerca volvulus 0.0041 0.0122 0.6876
Onchocerca volvulus 0.0035 0.0092 0.4564
Trichomonas vaginalis aldo-keto reductase, putative 0.0041 0.0122 0.7321
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0312 0.0303
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0031 0.1427
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0092 0.2936
Brugia malayi mbt repeat family protein 0.0048 0.0156 0.0147
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0064 0.0055
Schistosoma mansoni peroxidasin 0.003 0.0064 0.0055
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1942 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0041 0.0122 0.0113
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0064 0.0055
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0049 0.0164 0.0155
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0523 0.0523
Trichomonas vaginalis esterase, putative 0.0035 0.0092 0.534
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0152 0.0699 0.069
Leishmania major aldo-keto reductase-like protein 0.0041 0.0122 0.164
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0064 0.0055
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0031 0.007
Onchocerca volvulus Poor gastrulation protein homolog 0.0027 0.0046 0.1135
Schistosoma mansoni hypothetical protein 0.0047 0.0151 0.0142
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0049 0.0164 0.0155
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0031 0.0022
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0049 0.0164 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0064 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0064 0.0055
Echinococcus multilocularis GPCR, family 2 0.0047 0.0151 0.0142
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Brugia malayi MH2 domain containing protein 0.0118 0.0523 0.0514
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0042 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0041 0.0122 0.0113
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0092 0.0083
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0049 0.0164 0.0155
Mycobacterium ulcerans isocitrate lyase AceAb 0.0875 0.4457 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0099 0.0423 0.0414
Trichomonas vaginalis aldo-keto reductase, putative 0.0041 0.0122 0.7321
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0092 0.0206
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.1082 0.2429
Onchocerca volvulus Chorion peroxidase homolog 0.003 0.0064 0.2504
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0041 0.0122 0.164
Mycobacterium ulcerans lipase LipD 0.0035 0.0092 0.0206
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0092 0.1196
Brugia malayi Animal haem peroxidase family protein 0.003 0.0064 0.0055
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0092 0.0206
Schistosoma mansoni hypothetical protein 0.0101 0.0434 0.0425
Loa Loa (eye worm) hypothetical protein 0.0048 0.0156 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0064 0.0064
Echinococcus granulosus protein tyrosine phosphatase n9 0.0049 0.0164 0.0155
Loa Loa (eye worm) blistered cuticle protein 3 0.003 0.0064 0.0064
Schistosoma mansoni lamin 0.0026 0.0046 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0031 0.007
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0173 0.0164
Echinococcus multilocularis aldo keto reductase 0.0041 0.0122 0.0113
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0064 0.0055
Onchocerca volvulus Peroxidase homolog 0.003 0.0064 0.2504
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0064 0.0064
Onchocerca volvulus 0.0049 0.0164 1
Onchocerca volvulus 0.0041 0.0122 0.6876
Onchocerca volvulus 0.0041 0.0122 0.6876
Trypanosoma brucei trypanothione reductase 0.0037 0.0101 0.1331
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0092 0.0206
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0041 0.0122 0.164
Schistosoma mansoni hypothetical protein 0.0294 0.1437 0.1429
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0049 0.0164 0.0155
Loa Loa (eye worm) hypothetical protein 0.0024 0.0031 0.0031
Schistosoma mansoni peroxidasin 0.003 0.0064 0.0055
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0092 0.0206
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0064 0.2481
Brugia malayi Blistered cuticle protein 3 0.003 0.0064 0.0055
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.019 0.0181
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0049 0.0164 0.0155
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0049 0.0164 0.0164
Onchocerca volvulus 0.0035 0.0092 0.4564
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0101 0.1331
Loa Loa (eye worm) glutamate receptor 0.0065 0.0243 0.0243
Plasmodium vivax glutathione reductase, putative 0.0037 0.0101 0.3234
Loa Loa (eye worm) hypothetical protein 0.0054 0.019 0.019
Mycobacterium leprae Isocitrate lyase 0.041 0.204 0.4539
Schistosoma mansoni coup transcription factor 0.003 0.0064 0.0055
Brugia malayi Animal haem peroxidase family protein 0.003 0.0064 0.0055
Onchocerca volvulus 0.0049 0.0164 1
Onchocerca volvulus 0.0041 0.0122 0.6876
Plasmodium falciparum thioredoxin reductase 0.0037 0.0101 0.239
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0049 0.0164 0.0155
Onchocerca volvulus 0.0049 0.0164 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0092 0.0092
Loa Loa (eye worm) glutathione reductase 0.0037 0.0101 0.0101
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Onchocerca volvulus 0.0049 0.0164 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0064 0.0055
Brugia malayi Protein-tyrosine phosphatase 0.0049 0.0164 0.0155
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0104 0.0095
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0099 0.0423 0.0414
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0049 0.0164 0.0155
Mycobacterium ulcerans hypothetical protein 0.0024 0.0031 0.007
Onchocerca volvulus 0.003 0.0064 0.2504
Leishmania major hypothetical protein, conserved 0.0035 0.0092 0.1196
Brugia malayi mbt repeat family protein 0.0048 0.0156 0.0147
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.0398 0.0892
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0151 0.0142
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0225 0.0216
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0152 0.0699 1
Echinococcus granulosus carbonic anhydrase II 0.0152 0.0699 0.069
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0049 0.0164 0.0164
Loa Loa (eye worm) RNA binding protein 0.0063 0.0234 0.0234
Brugia malayi Metabotropic glutamate receptor precursor. 0.0164 0.0761 0.0752
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0049 0.0164 0.0155
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0151 0.0142
Schistosoma mansoni intermediate filament proteins 0.0026 0.0046 0.0036
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0225 0.0216
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0225 0.0216
Brugia malayi Protein-tyrosine phosphatase 0.0049 0.0164 0.0155
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0049 0.0164 0.224
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0049 0.0164 0.0155
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0049 0.0164 0.224
Loa Loa (eye worm) oxidoreductase 0.0041 0.0122 0.0122
Echinococcus granulosus carbonic anhydrase 0.0099 0.0423 0.0414
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0049 0.0164 0.0155
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0225 0.0216
Plasmodium falciparum glutathione reductase 0.0037 0.0101 0.239
Trichomonas vaginalis aldo-keto reductase, putative 0.0041 0.0122 0.7321
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0049 0.0164 0.0164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Loa Loa (eye worm) glutamate receptor 0.0164 0.0761 0.0761
Trichomonas vaginalis aldo-keto reductase, putative 0.0041 0.0122 0.7321
Onchocerca volvulus 0.0049 0.0164 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0041 0.0122 0.0113
Brugia malayi hypothetical protein 0.0051 0.0175 0.0166
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0049 0.0164 0.0164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0064 0.0064
Schistosoma mansoni pcd6 interacting protein-related 0.0049 0.0164 0.0155
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0041 0.0122 0.0113
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0101 0.3234
Schistosoma mansoni protein tyrosine phosphatase 0.0049 0.0164 0.0155
Schistosoma mansoni aldo-keto reductase 0.0041 0.0122 0.0113
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0234 0.0234
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0312 0.739
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0049 0.0164 0.0155
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0175 0.2404
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0064 0.0064
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0049 0.0164 0.0164
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0064 0.0055
Brugia malayi jmjC domain containing protein 0.0061 0.0225 0.0216
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0312 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Echinococcus multilocularis aldo keto reductase 0.0041 0.0122 0.0113
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0031 0.032
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0049 0.0164 0.0164
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0348 0.0782
Brugia malayi TAR-binding protein 0.0063 0.0234 0.0225
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0064 0.0055
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0225 0.0225
Trichomonas vaginalis aldo-keto reductase, putative 0.0041 0.0122 0.7321
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0064 0.0055
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0398 0.0892
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0049 0.0164 0.0155
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0434 0.0425
Brugia malayi intermediate filament protein 0.0026 0.0046 0.0036
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0049 0.0164 0.224
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0041 0.0122 0.0113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0064 0.0064
Toxoplasma gondii aldose reductase, putative 0.0041 0.0122 0.2737
Echinococcus granulosus carbonic anhydrase 0.0099 0.0423 0.0414
Brugia malayi hypothetical protein 0.003 0.0064 0.0055
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.0875 0.4457 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0041 0.0122 0.0113
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Brugia malayi Thioredoxin reductase 0.0037 0.0101 0.0092
Echinococcus granulosus lamin 0.0026 0.0046 0.0036
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0049 0.0164 0.0155
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Trypanosoma brucei prostaglandin f synthase 0.0041 0.0122 0.164
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0031 0.007
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0151 0.0142
Schistosoma mansoni nuclear hormone receptor 0.003 0.0064 0.0055
Schistosoma mansoni pol-related 0.0041 0.0122 0.0113
Onchocerca volvulus Peroxidasin homolog 0.003 0.0064 0.2504
Brugia malayi Animal haem peroxidase family protein 0.003 0.0064 0.0055
Loa Loa (eye worm) animal heme peroxidase 0.003 0.0064 0.0064
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0049 0.0164 0.0155
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0049 0.0164 0.0164
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0041 0.0122 0.0113
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0041 0.0122 0.0113
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0031 0.1427
Echinococcus multilocularis peroxidasin 0.003 0.0064 0.0055
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Brugia malayi RNA binding protein 0.0063 0.0234 0.0225
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0009 0.0216
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0031 0.032
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0202 0.0958 0.0949
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0064 0.0055
Loa Loa (eye worm) oxidoreductase 0.0041 0.0122 0.0122
Brugia malayi hypothetical protein 0.0049 0.0164 0.0155
Plasmodium falciparum carbonic anhydrase 0.0099 0.0423 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0041 0.0122 0.7321
Trichomonas vaginalis aldo-keto reductase, putative 0.0041 0.0122 0.7321
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0064 0.0055
Onchocerca volvulus 0.0041 0.0122 0.6876
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0092 0.534
Onchocerca volvulus Dual oxidase homolog 0.003 0.0064 0.2504
Schistosoma mansoni aldo-keto reductase 0.0041 0.0122 0.0113
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0064 0.0055
Mycobacterium tuberculosis Conserved protein 0.0035 0.0092 0.0206
Schistosoma mansoni metabotropic glutamate receptor 0.008 0.0323 0.0315
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.1942 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0046 0.0046
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0064 0.0055
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0041 0.0122 0.0113
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0099 0.0423 0.0414
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0137 0.0622 0.0614
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.0398 0.0828
Schistosoma mansoni lamin 0.0026 0.0046 0.0036
Echinococcus granulosus GPCR family 2 0.0047 0.0151 0.0142
Echinococcus multilocularis neuropeptide s receptor 0.0466 0.2329 0.2322
Loa Loa (eye worm) oxidoreductase 0.0041 0.0122 0.0122
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0064 0.0055
Onchocerca volvulus 0.0049 0.0164 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0049 0.0164 0.0155
Trypanosoma brucei carbonic anhydrase-like protein 0.0152 0.0699 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0064 0.0055
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0092 0.0206
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0092 0.0206
Onchocerca volvulus 0.0049 0.0164 1
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0156 0.0147
Echinococcus multilocularis aldo keto reductase 0.0041 0.0122 0.0113
Brugia malayi nuclear receptor NHR-88 0.003 0.0064 0.0055
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0234 0.0225
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0092 0.0083
Loa Loa (eye worm) oxidoreductase 0.0041 0.0122 0.0122
Schistosoma mansoni hypothetical protein 0.0047 0.0151 0.0142
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0152 0.0699 0.069
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0064 0.0055
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0156 0.0147
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0348 0.0782
Loa Loa (eye worm) hypothetical protein 0.0099 0.0423 0.0423
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0064 0.0055
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Toxoplasma gondii ABC1 family protein 0.0035 0.0092 0.1996
Loa Loa (eye worm) hypothetical protein 0.0047 0.0151 0.0151
Loa Loa (eye worm) protein tyrosine phosphatase 0.0049 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0051 0.0175 0.0175
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0234 0.0225
Brugia malayi steroid hormone receptor 0.003 0.0064 0.0055
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0031 0.007
Onchocerca volvulus 0.0049 0.0164 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Onchocerca volvulus 0.003 0.0064 0.2504
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0099 0.0423 0.0414
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0049 0.0164 0.0164
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0041 0.0122 0.0113
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0092 0.534
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0151 0.0142
Giardia lamblia Aldose reductase 0.0041 0.0122 0.7321
Mycobacterium ulcerans isocitrate lyase Icl 0.0875 0.4457 1
Echinococcus granulosus neuropeptide s receptor 0.0466 0.2329 0.2322
Onchocerca volvulus 0.003 0.0064 0.2504
Onchocerca volvulus 0.0049 0.0164 1
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0101 0.0101
Leishmania major hypothetical protein, conserved 0.0051 0.0175 0.2404
Echinococcus multilocularis lamin 0.0026 0.0046 0.0036
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0047 0.1254
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0049 0.0164 0.0155
Echinococcus multilocularis neuropeptide receptor A26 0.0466 0.2329 0.2322
Echinococcus granulosus hypothetical protein 0.0041 0.0122 0.0113
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Echinococcus multilocularis carbonic anhydrase II 0.0152 0.0699 0.069
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0064 0.0055
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0049 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0099 0.0423 0.0423
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0031 0.0022
Loa Loa (eye worm) beta-lactamase 0.0035 0.0092 0.0092
Trichomonas vaginalis aldo/keto reductase, putative 0.0041 0.0122 0.7321
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0312 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Trichomonas vaginalis pten, drome, putative 0.0049 0.0164 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0031 0.007
Echinococcus granulosus GPCR family 3 C terminal 0.0027 0.0046 0.0037
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0348 0.0782
Loa Loa (eye worm) hypothetical protein 0.0026 0.0046 0.0046
Onchocerca volvulus 0.0049 0.0164 1
Trypanosoma brucei aldo-keto reductase, putative 0.0041 0.0122 0.164
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0151 0.0151
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0049 0.0164 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0064 0.0055
Onchocerca volvulus 0.0049 0.0164 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0042 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0064 0.0055
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0031 0.007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0064 0.0055
Trypanosoma cruzi aldo-keto reductase 0.0041 0.0122 0.164
Echinococcus granulosus carbonic anhydrase 0.0099 0.0423 0.0414
Echinococcus multilocularis carbonic anhydrase 0.0099 0.0423 0.0414
Schistosoma mansoni protein tyrosine phosphatase 0.0049 0.0164 0.0155
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0092 0.1196
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0049 0.0164 0.0155
Loa Loa (eye worm) hypothetical protein 0.0035 0.0092 0.0092
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0312 0.7333
Onchocerca volvulus 0.0049 0.0164 1
Echinococcus granulosus aldo keto reductase 0.0041 0.0122 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0092 0.1196
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0175 0.5603
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0348 0.0782
Onchocerca volvulus 0.0049 0.0164 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0312 0.0312
Toxoplasma gondii hypothetical protein 0.0099 0.0423 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0041 0.0122 0.0113
Loa Loa (eye worm) hypothetical protein 0.0148 0.0677 0.0677
Mycobacterium tuberculosis Probable reductase 0.0085 0.0348 0.0782
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0049 0.0164 0.0155
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0009 0.0293
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Brugia malayi metabotropic glutamate receptor type 2 0.008 0.0323 0.0315
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0049 0.0164 0.0155
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Trichomonas vaginalis aldo-keto reductase, putative 0.0041 0.0122 0.7321
Trichomonas vaginalis aldo-keto reductase, putative 0.0041 0.0122 0.7321
Echinococcus multilocularis aldo keto reductase 0.0041 0.0122 0.0113
Onchocerca volvulus 0.0049 0.0164 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0122 0.0122
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0049 0.0164 0.0155
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0064 0.0055
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0225 0.0216
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0064 0.0055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0064 0.0055
Loa Loa (eye worm) animal heme peroxidase 0.003 0.0064 0.0064
Brugia malayi hypothetical protein 0.0049 0.0164 0.0155
Trichomonas vaginalis aldo-keto reductase, putative 0.0041 0.0122 0.7321
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.0906 0.0898
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0031 0.007
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0009 0.0009
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0151 0.0142
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0009 0.002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.0677 0.0668
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0234 0.0225
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0092 0.534
Onchocerca volvulus 0.0049 0.0164 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0064 0.0055
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0049 0.0164 0.0164
Giardia lamblia Protein tyrosine phosphatase 0.0049 0.0164 1
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0064 0.0055
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0348 0.0782
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0047 0.1116
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0156 0.0147
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0064 0.0055
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0049 0.0164 0.0155
Schistosoma mansoni carbonic anhydrase-related 0.0099 0.0423 0.0414
Brugia malayi Peroxidasin 0.003 0.0064 0.0055
Leishmania major prostaglandin f synthase, putative 0.0041 0.0122 0.164
Echinococcus granulosus FTZ F1 alpha 0.003 0.0064 0.0055
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0041 0.0122 0.0113
Echinococcus granulosus microtubule associated protein 2 0.137 0.703 0.7028
Brugia malayi Protein-tyrosine phosphatase 1 0.0049 0.0164 0.0155
Echinococcus multilocularis aldehyde reductase 0.0029 0.006 0.0051
Echinococcus granulosus aldehyde reductase 0.0029 0.006 0.0051
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0175 0.4141
Echinococcus granulosus metabotropic glutamate receptor 2 0.0137 0.0622 0.0614
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0049 0.0164 0.0155
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0049 0.0164 0.0164
Onchocerca volvulus 0.0026 0.0046 0.1082
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0049 0.0164 0.0164
Echinococcus granulosus neuropeptide receptor A26 0.0466 0.2329 0.2322
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0312 0.0701
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0092 0.534
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.019 0.0181
Echinococcus multilocularis GPCR, family 3, C terminal 0.0027 0.0046 0.0037
Mycobacterium leprae Conserved hypothetical protein 0.0029 0.006 0.0065
Brugia malayi beta-lactamase family protein 0.0035 0.0092 0.0083
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0041 0.0122 0.0113
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0049 0.0164 0.0155
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0041 0.0122 0.7321
Brugia malayi Probable ClpP-like protease 0.0078 0.0312 0.0303
Trypanosoma cruzi aldo/keto reductase, putative 0.0041 0.0122 0.164
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0049 0.0164 0.0164
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Toxoplasma gondii hypothetical protein 0.0027 0.0047 0.092
Loa Loa (eye worm) hypothetical protein 0.0027 0.0046 0.0046
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0234 0.0234
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0234 0.0225
Giardia lamblia Aldose reductase 0.0041 0.0122 0.7321
Mycobacterium ulcerans hypothetical protein 0.0035 0.0092 0.0206
Leishmania major carbonic anhydrase-like protein 0.0152 0.0699 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0156 0.0147
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0047 0.151
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0049 0.0164 0.0164
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0175 0.4011
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0049 0.0164 0.0164
Echinococcus multilocularis 0.0049 0.0164 0.0155
Echinococcus multilocularis hypothetical protein 0.0049 0.0164 0.0155
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0049 0.0164 0.0155
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0049 0.0164 0.0155
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0064 0.0055
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0049 0.0164 0.0155
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0234 0.0225
Onchocerca volvulus 0.0049 0.0164 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1942 1 1
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0049 0.0164 0.0164
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0156 0.0147
Brugia malayi Animal haem peroxidase family protein 0.003 0.0064 0.0055
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0041 0.0122 0.0113
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0049 0.0164 0.0155
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0049 0.0164 0.0155
Mycobacterium ulcerans oxidoreductase 0.0041 0.0122 0.0274
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0187 0.0877 0.0869
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0092 0.534
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0092 0.0083
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0049 0.0164 0.0155
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0049 0.0164 0.0155
Brugia malayi beta-lactamase family protein 0.0035 0.0092 0.0083
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0152 0.0699 0.069
Echinococcus granulosus tar DNA binding protein 0.0063 0.0234 0.0225
Onchocerca volvulus Peroxidase homolog 0.003 0.0064 0.2504
Loa Loa (eye worm) hypothetical protein 0.0024 0.0031 0.0031
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0104 0.0095
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0234 0.0225
Echinococcus granulosus peroxidasin 0.003 0.0064 0.0055
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0041 0.0122 0.0113
Schistosoma mansoni carbonic anhydrase 0.0099 0.0423 0.0414
Echinococcus granulosus aldo keto reductase 0.0041 0.0122 0.0113
Loa Loa (eye worm) MBCTL1 0.0054 0.019 0.019
Echinococcus granulosus intermediate filament protein 0.0026 0.0046 0.0036
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0064 0.0055
Brugia malayi Animal haem peroxidase family protein 0.003 0.0064 0.0055
Onchocerca volvulus 0.0041 0.0122 0.6876
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0225 0.0216
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0348 0.0717
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.0398 0.0892
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0049 0.0164 0.0155
Schistosoma mansoni hypothetical protein 0.0099 0.0423 0.0414
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0064 0.0055
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0049 0.0164 0.0155
Brugia malayi hypothetical protein 0.0049 0.0164 0.0155
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0041 0.0122 0.0113
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0049 0.0164 0.0155
Loa Loa (eye worm) hypothetical protein 0.0035 0.0092 0.0092
Onchocerca volvulus 0.0035 0.0092 0.4564
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1942 1 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0049 0.0164 0.0155
Loa Loa (eye worm) hypothetical protein 0.0035 0.0092 0.0092
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0156 0.0147
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0041 0.0122 0.0113
Schistosoma mansoni thyroid hormone receptor 0.003 0.0064 0.0055
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0312 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0423 0.0423
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0049 0.0164 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0028 0.0019
Leishmania major trypanothione reductase 0.0037 0.0101 0.1331
Mycobacterium leprae PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) 0.0875 0.4457 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0049 0.0164 0.0164
Echinococcus granulosus metabotropic glutamate receptor 5 0.0202 0.0958 0.0949
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0092 0.0206
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0092 0.0083
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0049 0.0164 0.0155
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0099 0.0423 0.0423
Echinococcus multilocularis microtubule associated protein 2 0.137 0.703 0.7028
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0523 0.0523
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.0875 0.4457 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0049 0.0164 0.0155
Entamoeba histolytica aldose reductase, putative 0.0041 0.0122 0.7321
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0312 0.0303
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0027 0.0046 0.0037
Toxoplasma gondii thioredoxin reductase 0.0037 0.0101 0.2222
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0049 0.0164 0.0155
Echinococcus multilocularis musashi 0.0026 0.0046 0.0036

Activities

Activity type Activity value Assay description Source Reference
ED50 (binding) = 20 nM Compound was evaluated for the inhibition of [3H]-naloxone binding to opioid receptor mu of mouse brain homogenate at 1 nM in the absence of sodium ChEMBL. 1433169
ED50 (binding) = 20 nM Compound was evaluated for the inhibition of [3H]-naloxone binding to opioid receptor mu of mouse brain homogenate at 1 nM in the absence of sodium ChEMBL. 1433169
ED50 (binding) = 40 nM Compound was evaluated for the inhibition of [3H]-naloxone binding to opioid receptor mu mouse brain homogenate at 1 nM in the presence of 100 mM sodium; ED50 = 40-50 nM ChEMBL. 1433169
ED50 (binding) = 40 nM Compound was evaluated for the inhibition of [3H]-naloxone binding to opioid receptor mu mouse brain homogenate at 1 nM in the presence of 100 mM sodium; ED50 = 40-50 nM ChEMBL. 1433169
ED50 (functional) = 9 uM Compound was evaluated for the hot-plate analgesic activity ChEMBL. 1433169
ED50 (functional) = 9 uM Compound was evaluated for the hot-plate analgesic activity ChEMBL. 1433169
IC50 (binding) = 20 uM Tested for displacement of radioligand [3H]-Naloxone from opiate receptor ChEMBL. 8410989
IC50 (binding) = 20 uM Tested for displacement of radioligand [3H]-Naloxone from opiate receptor ChEMBL. 8410989
Ki (binding) = 2615 nM Ability to compete with [3H]-YM-09151-2 binding to the human dopamine receptor D3 transfected in CHO cells ChEMBL. 14521403
Ki (binding) = 2615 nM Ability to compete with [3H]-YM-09151-2 binding to the human dopamine receptor D3 transfected in CHO cells ChEMBL. 14521403
Ratio (functional) = 2 Ratio between the ED50 values in presence and absence of sodium; value ranges from 2-2.5 ChEMBL. 1433169

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.