Detailed information for compound 153140

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 421.444 | Formula: C20H27N3O7
  • H donors: 4 H acceptors: 5 LogP: 1.04 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N[C@H](C(=O)N[C@H](C(=O)N[C@H]1CC(=O)OC1O)C)C(C)C)OCc1ccccc1
  • InChi: 1S/C20H27N3O7/c1-11(2)16(23-20(28)29-10-13-7-5-4-6-8-13)18(26)21-12(3)17(25)22-14-9-15(24)30-19(14)27/h4-8,11-12,14,16,19,27H,9-10H2,1-3H3,(H,21,26)(H,22,25)(H,23,28)/t12-,14-,16-,19?/m0/s1
  • InChiKey: FUNMHZMHJQCKGK-KGIQCEPESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus caspase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans hypothetical protein 0.0153 0.0131 1
Echinococcus granulosus neuropeptide FF receptor 2 0.2312 0.2997 0.2995
Toxoplasma gondii subtilisin SUB10 0.0111 0.0075 0.0571
Schistosoma mansoni tubulin subunit beta 0.0088 0.0044 0.0057
Echinococcus granulosus neuropeptides capa receptor 0.0435 0.0504 0.0502
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0435 0.0504 0.0646
Brugia malayi hypothetical protein 0.0435 0.0504 0.1674
Trichomonas vaginalis AGC family protein kinase 0.0166 0.0147 0.0827
Loa Loa (eye worm) hypothetical protein 0.0133 0.0104 0.0338
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0138 0.011 0.0141
Brugia malayi Trypsin-like protease protein 5 0.0153 0.0131 0.0428
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0057 0.0002 0.0002
Plasmodium falciparum subtilisin-like protease 1 0.0111 0.0075 0.0648
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Trichomonas vaginalis cyclin B3, putative 0.022 0.0219 0.1264
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0435 0.0504 0.0646
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0435 0.0504 0.0646
Echinococcus granulosus beta tubulin 0.0088 0.0044 0.0042
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Echinococcus granulosus tm gpcr rhodopsin 0.0435 0.0504 0.0502
Echinococcus granulosus serine threonine protein kinase nrc 0.0104 0.0065 0.0063
Brugia malayi putative neuropeptide receptor 0.0435 0.0504 0.1674
Onchocerca volvulus 0.008 0.0033 0.026
Echinococcus multilocularis glycoprotein Antigen 5 0.0153 0.0131 0.0129
Echinococcus granulosus neuroendocrine convertase 2 0.1687 0.2166 0.2165
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Loa Loa (eye worm) neuropeptide F receptor 0.0435 0.0504 0.1674
Toxoplasma gondii calcium binding egf domain-containing protein 0.0097 0.0056 0.0314
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0131 0.0167
Echinococcus multilocularis neuropeptide receptor 0.0435 0.0504 0.0502
Echinococcus granulosus rhodopsin orphan GPCR 0.0435 0.0504 0.0502
Toxoplasma gondii subtilisin SUB4 0.0111 0.0075 0.0571
Echinococcus granulosus cathepsin b 0.0138 0.011 0.0108
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0111 0.0075 0.0629
Schistosoma mansoni hypothetical protein 0.0442 0.0514 0.0658
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Echinococcus multilocularis neuropeptide receptor A26 0.0435 0.0504 0.0502
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0102 0.0062 0.006
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0435 0.0504 0.0646
Echinococcus granulosus cyclins 0.022 0.0219 0.0217
Loa Loa (eye worm) hypothetical protein 0.008 0.0033 0.0104
Echinococcus granulosus biogenic amine 5HT receptor 0.0435 0.0504 0.0502
Echinococcus multilocularis neuropeptides capa receptor 0.0435 0.0504 0.0502
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Schistosoma mansoni amine GPCR 0.0435 0.0504 0.0646
Echinococcus granulosus tubulin beta 4A class IVa 0.0088 0.0044 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0075 0.0381
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0435 0.0504 0.0646
Echinococcus multilocularis rac serine:threonine kinase 0.0114 0.0079 0.0077
Brugia malayi G protein-coupled receptor 0.0435 0.0504 0.1674
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0665 0.081 0.4886
Trichomonas vaginalis cyclins, putative 0.0453 0.0528 0.3162
Entamoeba histolytica protein kinase 2, putative 0.0104 0.0065 0.0431
Loa Loa (eye worm) BEN-1 protein 0.0088 0.0044 0.014
Plasmodium falciparum protein kinase 5 0.014 0.0112 0.1446
Loa Loa (eye worm) hypothetical protein 0.0071 0.0021 0.0063
Echinococcus granulosus dro:myosuppressin receptor 0.0435 0.0504 0.0502
Echinococcus multilocularis fmrfamide receptor 0.0435 0.0504 0.0502
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1293 0.1644 1
Brugia malayi PAN domain containing protein 0.008 0.0033 0.0104
Loa Loa (eye worm) hypothetical protein 0.0073 0.0023 0.007
Echinococcus granulosus Tubulin beta 2C chain 0.0088 0.0044 0.0042
Schistosoma mansoni neuropeptide receptor 0.0435 0.0504 0.0646
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Echinococcus granulosus neuropeptide receptor A26 0.0435 0.0504 0.0502
Brugia malayi hypothetical protein 0.0153 0.0131 0.0428
Plasmodium falciparum subtilisin-like protease 3 0.0111 0.0075 0.0648
Echinococcus granulosus glycoprotein Antigen 5 0.0153 0.0131 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.0596 0.3577
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0067 0.0016 0.0014
Echinococcus granulosus rhodopsin orphan GPCR 0.0435 0.0504 0.0502
Echinococcus multilocularis allatostatin A receptor 0.0435 0.0504 0.0502
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0553 0.0662 0.398
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0435 0.0504 0.0646
Onchocerca volvulus 0.0153 0.0131 0.107
Loa Loa (eye worm) proprotein convertase 2 0.0665 0.081 0.2693
Schistosoma mansoni inhibitor of apoptosis protein 0.0136 0.0107 0.0137
Echinococcus granulosus somatostatin receptor 0.0435 0.0504 0.0502
Schistosoma mansoni hypothetical protein 0.0153 0.0131 0.0167
Echinococcus granulosus Tolloid protein 1 0.0101 0.0061 0.0059
Trypanosoma brucei RNA helicase, putative 0.0219 0.0217 0.3571
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Echinococcus multilocularis Tubulin beta 2C chain 0.0088 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.0596 0.3577
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0101 0.0061 0.0197
Echinococcus granulosus epidermal growth factor receptor 0.0259 0.0271 0.027
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0104 0.0065 0.0063
Schistosoma mansoni hypothetical protein 0.0435 0.0504 0.0646
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0131 0.0167
Toxoplasma gondii subtilisin SUB5 0.0111 0.0075 0.0571
Echinococcus granulosus rhodopsin orphan GPCR 0.0435 0.0504 0.0502
Onchocerca volvulus 0.0073 0.0023 0.0176
Echinococcus multilocularis nervana 2 0.0102 0.0062 0.006
Onchocerca volvulus 0.0153 0.0131 0.107
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0435 0.0504 0.0646
Onchocerca volvulus 0.0806 0.0997 0.8301
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0553 0.0662 0.398
Schistosoma mansoni hypothetical protein 0.0219 0.0217 0.0278
Echinococcus granulosus g protein coupled receptor 0.0435 0.0504 0.0502
Loa Loa (eye worm) hypothetical protein 0.0097 0.0056 0.018
Trichomonas vaginalis cyclin B, putative 0.0453 0.0528 0.3162
Loa Loa (eye worm) tubulin beta-4 chain 0.0088 0.0044 0.014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0665 0.081 0.4886
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0111 0.0075 0.0441
Toxoplasma gondii kringle domain-containing protein 0.0442 0.0514 0.6623
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Echinococcus granulosus hypothetical protein 0.0435 0.0504 0.0502
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0435 0.0504 0.0646
Trichomonas vaginalis cyclins, putative 0.0453 0.0528 0.3162
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.014 0.0112 0.1402
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Brugia malayi follicle stimulating hormone receptor 0.0435 0.0504 0.1674
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0435 0.0504 0.0646
Loa Loa (eye worm) tubulin beta chain 0.0088 0.0044 0.014
Trichomonas vaginalis AGC family protein kinase 0.0166 0.0147 0.0827
Echinococcus multilocularis cyclins 0.022 0.0219 0.0217
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0131 0.0167
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0435 0.0504 0.0646
Echinococcus granulosus neuropeptide receptor 0.06 0.0724 0.0722
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Trypanosoma brucei subtilisin peptidase 0.0111 0.0075 0.0629
Echinococcus multilocularis cyclin dependent kinase 1 0.014 0.0112 0.011
Brugia malayi PAN domain containing protein 0.008 0.0033 0.0104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0435 0.0504 0.0646
Echinococcus multilocularis cyclins 0.022 0.0219 0.0217
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0111 0.0075 0.0441
Trichomonas vaginalis tubulin epsilon chain, putative 0.0088 0.0044 0.0194
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Echinococcus multilocularis geminin 0.0165 0.0146 0.0144
Brugia malayi hypothetical protein 0.0435 0.0504 0.1674
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0153 0.0131 0.0129
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0435 0.0504 0.1674
Brugia malayi Trypsin family protein 0.0153 0.0131 0.0428
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0111 0.0075 0.0073
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0153 0.0131 0.0428
Toxoplasma gondii hypothetical protein 0.0167 0.0148 0.1586
Loa Loa (eye worm) hypothetical protein 0.008 0.0033 0.0104
Echinococcus multilocularis transmembrane protease serine 3 0.0153 0.0131 0.0129
Echinococcus multilocularis rhodopsin orphan GPCR 0.0435 0.0504 0.0502
Onchocerca volvulus 0.0435 0.0504 0.4187
Brugia malayi hypothetical protein 0.0435 0.0504 0.1674
Loa Loa (eye worm) G-protein coupled receptor 0.0435 0.0504 0.1674
Onchocerca volvulus 0.0435 0.0504 0.4187
Onchocerca volvulus 0.0153 0.0131 0.107
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0131 0.0167
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0088 0.0044 0.0042
Echinococcus multilocularis beta tubulin 0.0088 0.0044 0.0042
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0435 0.0504 0.0502
Loa Loa (eye worm) hypothetical protein 0.008 0.0033 0.0104
Echinococcus multilocularis neuropeptide s receptor 0.0435 0.0504 0.0502
Loa Loa (eye worm) hypothetical protein 0.096 0.1201 0.3998
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0161 0.014 0.0784
Brugia malayi neuropeptide F receptor 0.0435 0.0504 0.1674
Loa Loa (eye worm) subtilase 0.0111 0.0075 0.0242
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0111 0.0075 0.0242
Loa Loa (eye worm) AGC/AKT protein kinase 0.0166 0.0147 0.0484
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0435 0.0504 0.1674
Brugia malayi Serotonin receptor 0.0435 0.0504 0.1674
Plasmodium falciparum subtilisin-like protease 2 0.0111 0.0075 0.0648
Echinococcus multilocularis somatostatin receptor 0.0435 0.0504 0.0502
Onchocerca volvulus 0.0435 0.0504 0.4187
Loa Loa (eye worm) neuropeptide F receptor 0.0435 0.0504 0.1674
Brugia malayi Melatonin receptor type 1A 0.0435 0.0504 0.1674
Loa Loa (eye worm) hypothetical protein 0.0162 0.0142 0.0465
Onchocerca volvulus 0.0435 0.0504 0.4187
Echinococcus multilocularis Glutaredoxin protein 5 0.0102 0.0062 0.006
Plasmodium vivax subtilisin-like protease 1 0.0111 0.0075 0.0648
Brugia malayi G-protein coupled receptor 0.0435 0.0504 0.1674
Onchocerca volvulus 0.008 0.0033 0.026
Schistosoma mansoni neuropeptide F-like receptor 0.0435 0.0504 0.0646
Loa Loa (eye worm) cyclin domain-containing protein 0.022 0.0219 0.0722
Schistosoma mansoni cyclins 0.022 0.0219 0.028
Loa Loa (eye worm) hypothetical protein 0.0094 0.0051 0.0164
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0104 0.0065 0.0063
Echinococcus multilocularis epidermal growth factor receptor 0.0259 0.0271 0.027
Echinococcus granulosus cyclin b3 0.022 0.0219 0.0217
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0057 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0105 0.0066 0.0213
Loa Loa (eye worm) hypothetical protein 0.0442 0.0514 0.1706
Toxoplasma gondii beta tubulin 0.0088 0.0044 0.0151
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0157 0.0136 0.0174
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0111 0.0075 1
Echinococcus multilocularis fibrillin 1 0.0099 0.0058 0.0056
Echinococcus granulosus 7TM GPCR rhodopsin 0.0435 0.0504 0.0502
Schistosoma mansoni tubulin subunit beta 0.0088 0.0044 0.0057
Trichomonas vaginalis AGC family protein kinase 0.0166 0.0147 0.0827
Brugia malayi PAN domain containing protein 0.008 0.0033 0.0104
Brugia malayi Serotonin receptor 0.0435 0.0504 0.1674
Entamoeba histolytica protein kinase, putative 0.0156 0.0134 0.1852
Echinococcus granulosus tissue type plasminogen activator 0.0442 0.0514 0.0512
Onchocerca volvulus 0.0435 0.0504 0.4187
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0967 0.1211 0.1551
Echinococcus granulosus tubulin beta 1 chain 0.0088 0.0044 0.0042
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Onchocerca volvulus 0.0153 0.0131 0.107
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0435 0.0504 0.1674
Entamoeba histolytica PH domain containing protein kinase, putative 0.0114 0.0079 0.071
Echinococcus granulosus orexin receptor type 2 0.0435 0.0504 0.0502
Toxoplasma gondii subtilisin SUB7 0.0111 0.0075 0.0571
Echinococcus multilocularis serotonin receptor 0.0435 0.0504 0.0502
Onchocerca volvulus 0.0435 0.0504 0.4187
Echinococcus granulosus 7tm_1 domain containing protein 0.0435 0.0504 0.0502
Echinococcus multilocularis cyclins 0.022 0.0219 0.0217
Echinococcus granulosus rhodopsin orphan GPCR 0.0435 0.0504 0.0502
Brugia malayi Cell death protein 3 precursor 0.0133 0.0104 0.0338
Toxoplasma gondii PAN domain-containing protein 0.0626 0.0758 1
Echinococcus multilocularis serotonin receptor 0.0435 0.0504 0.0502
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Loa Loa (eye worm) hypothetical protein 0.0111 0.0075 0.0242
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0111 0.0075 0.0096
Echinococcus granulosus apoptotic protease activating factor 1 0.0112 0.0075 0.0073
Onchocerca volvulus 0.008 0.0033 0.0258
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Loa Loa (eye worm) hypothetical protein 0.0166 0.0148 0.0486
Leishmania major hypothetical protein, conserved 0.0442 0.0514 0.9695
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0112 0.061
Echinococcus granulosus neuropeptide receptor 0.0435 0.0504 0.0502
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Onchocerca volvulus 0.008 0.0033 0.026
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0435 0.0504 0.0502
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0101 0.0061 0.0197
Echinococcus granulosus g protein coupled receptor 0.0435 0.0504 0.0502
Loa Loa (eye worm) tubulin beta-2A chain 0.0088 0.0044 0.014
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.014 0.0112 0.0367
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Brugia malayi Dopamine receptor protein 1 0.0435 0.0504 0.1674
Trypanosoma brucei cdc2-related kinase 1 0.014 0.0112 0.1402
Toxoplasma gondii subtilisin SUB11 0.0111 0.0075 0.0571
Brugia malayi cathepsin B-like cysteine proteinase 0.0138 0.011 0.0359
Plasmodium falciparum cysteine repeat modular protein 1 0.0442 0.0514 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0435 0.0504 0.0646
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0104 0.0065 0.0445
Onchocerca volvulus 0.0435 0.0504 0.4187
Giardia lamblia Kinase, AGC PKA 0.0104 0.0065 0.0267
Schistosoma mansoni growth hormone secretagogue receptor 0.0435 0.0504 0.0646
Loa Loa (eye worm) hypothetical protein 0.0153 0.0131 0.0428
Toxoplasma gondii calcium binding egf domain-containing protein 0.0097 0.0056 0.0314
Schistosoma mansoni hypothetical protein 0.0435 0.0504 0.0646
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0665 0.081 0.1037
Onchocerca volvulus 0.008 0.0033 0.026
Schistosoma mansoni amine GPCR 0.0435 0.0504 0.0646
Echinococcus multilocularis nervana 2 0.0102 0.0062 0.006
Echinococcus granulosus cyclin B 0.0453 0.0528 0.0526
Onchocerca volvulus Cell death protein 3 homolog 0.0133 0.0104 0.0845
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.014 0.0112 0.0367
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0435 0.0504 0.1674
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0115 0.008 0.0734
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0435 0.0504 0.0502
Echinococcus multilocularis cathepsin b 0.0138 0.011 0.0108
Brugia malayi Muscle positioning protein 4 0.0073 0.0024 0.0074
Loa Loa (eye worm) hypothetical protein 0.008 0.0033 0.0104
Trichomonas vaginalis AGC family protein kinase 0.0166 0.0147 0.0827
Toxoplasma gondii subtilisin SUB1 0.0111 0.0075 0.0571
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.014 0.0112 0.1402
Brugia malayi Protein kinase domain containing protein 0.014 0.0112 0.0367
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0153 0.0131 0.0167
Onchocerca volvulus 0.008 0.0033 0.026
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Echinococcus granulosus alpha 1A adrenergic receptor 0.0435 0.0504 0.0502
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.0596 0.3577
Echinococcus granulosus transmembrane protease serine 3 0.0153 0.0131 0.0129
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0131 0.0167
Entamoeba histolytica cyclin family protein 0.022 0.0219 0.3605
Echinococcus multilocularis g protein coupled receptor 0.0435 0.0504 0.0502
Echinococcus granulosus neuropeptides capa receptor 0.1468 0.1877 0.1875
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0131 0.0167
Onchocerca volvulus 0.0435 0.0504 0.4187
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Loa Loa (eye worm) hypothetical protein 0.0094 0.0051 0.0164
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Brugia malayi larval opioid receptor 0.0435 0.0504 0.1674
Onchocerca volvulus 0.0435 0.0504 0.4187
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Echinococcus multilocularis cyclin B 0.0453 0.0528 0.0526
Brugia malayi PAN domain containing protein 0.008 0.0033 0.0104
Loa Loa (eye worm) hypothetical protein 0.0069 0.0019 0.0056
Echinococcus multilocularis Tolloid protein 1 0.0101 0.0061 0.0059
Onchocerca volvulus 0.0435 0.0504 0.4187
Echinococcus granulosus cyclin dependent kinase 1 0.014 0.0112 0.011
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0153 0.0131 0.0167
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0435 0.0504 0.0502
Trypanosoma cruzi hypothetical protein, conserved 0.0442 0.0514 0.9695
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0115 0.008 0.0734
Entamoeba histolytica cyclin, putative 0.022 0.0219 0.3605
Loa Loa (eye worm) hypothetical protein 0.0101 0.0061 0.0197
Echinococcus multilocularis cyclin b3 0.022 0.0219 0.0217
Echinococcus granulosus beta tubulin 0.0088 0.0044 0.0042
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Brugia malayi Calcium binding EGF domain containing protein 0.0097 0.0056 0.018
Echinococcus multilocularis G-protein coupled receptor, putative 0.0435 0.0504 0.0502
Echinococcus multilocularis g protein coupled receptor 0.0435 0.0504 0.0502
Echinococcus multilocularis sex peptide receptor 0.0435 0.0504 0.0502
Entamoeba histolytica protein kinase, putative 0.0166 0.0147 0.2131
Echinococcus multilocularis neuropeptides capa receptor 0.1468 0.1877 0.1875
Trypanosoma cruzi cdc2-related kinase 3 0.014 0.0112 0.1402
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0153 0.0131 0.0129
Trichomonas vaginalis cyclin B, putative 0.022 0.0219 0.1264
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0219 0.1264
Schistosoma mansoni amine GPCR 0.0435 0.0504 0.0646
Brugia malayi cell division control protein 2 homolog 0.014 0.0112 0.0367
Mycobacterium tuberculosis Possible exported protein 0.0494 0.0583 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0435 0.0504 0.0502
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0435 0.0504 0.4187
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Loa Loa (eye worm) tubulin beta-1 chain 0.0088 0.0044 0.014
Echinococcus granulosus endothelin converting enzyme 1 0.0094 0.0051 0.0049
Schistosoma mansoni histamine h1 receptor 0.0435 0.0504 0.0646
Toxoplasma gondii peptidase family M13 protein 0.0094 0.0051 0.0248
Echinococcus granulosus furin 0.2315 0.3 0.2999
Schistosoma mansoni amine GPCR 0.0435 0.0504 0.0646
Entamoeba histolytica PH domain containing protein kinase, putative 0.0114 0.0079 0.071
Echinococcus granulosus caspase 2 0.0133 0.0104 0.0102
Leishmania major cyclin 0.0453 0.0528 1
Schistosoma mansoni serine/threonine-protein kinase 0.0114 0.0079 0.0101
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Loa Loa (eye worm) hypothetical protein 0.0071 0.0021 0.0063
Trypanosoma brucei rac serine-threonine kinase, putative 0.0166 0.0147 0.2131
Onchocerca volvulus 0.0136 0.0107 0.0873
Echinococcus multilocularis rhodopsin orphan GPCR 0.0435 0.0504 0.0502
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0435 0.0504 0.0646
Echinococcus multilocularis Tubulin beta 2C chain 0.0088 0.0044 0.0042
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0435 0.0504 0.0502
Loa Loa (eye worm) BEN-1 protein 0.0088 0.0044 0.014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Giardia lamblia Hypothetical protein 0.022 0.0219 0.2231
Loa Loa (eye worm) hypothetical protein 0.0073 0.0024 0.0074
Onchocerca volvulus 0.0435 0.0504 0.4187
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.0596 0.3577
Echinococcus multilocularis tubulin subunit beta 0.0088 0.0044 0.0042
Giardia lamblia Furin precursor putative serine protease 0.0553 0.0662 0.7893
Entamoeba histolytica cell division protein kinase 2, putative 0.014 0.0112 0.1402
Brugia malayi hypothetical protein 0.0435 0.0504 0.1674
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0435 0.0504 0.0502
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0075 0.0381
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0442 0.0514 1
Brugia malayi Tubulin beta-1 chain 0.0088 0.0044 0.014
Echinococcus granulosus rhodopsin orphan GPCR 0.0435 0.0504 0.0502
Schistosoma mansoni tubulin subunit beta 0.0088 0.0044 0.0057
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0131 0.0167
Onchocerca volvulus Deterin homolog 0.0136 0.0107 0.0873
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0435 0.0504 0.0502
Echinococcus granulosus Tubulin beta 2C chain 0.0088 0.0044 0.0042
Schistosoma mansoni hypothetical protein 0.0504 0.0596 0.0763
Trypanosoma cruzi subtilisin peptidase 0.0111 0.0075 0.0629
Trypanosoma cruzi cdc2-related kinase 1 0.014 0.0112 0.1402
Echinococcus multilocularis endothelin converting enzyme 1 0.0094 0.0051 0.0049
Echinococcus granulosus Tubulin beta 2C chain 0.0088 0.0044 0.0042
Trypanosoma cruzi cyclin, putative 0.0453 0.0528 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0156 0.0134 0.0439
Schistosoma mansoni hypothetical protein 0.0136 0.0107 0.0137
Trypanosoma cruzi Protein kinase B 0.0114 0.0079 0.071
Giardia lamblia Kinase, CMGC CDK 0.014 0.0112 0.0867
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0153 0.0131 0.0129
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0153 0.0131 0.0167
Schistosoma mansoni hypothetical protein 0.0112 0.0075 0.0096
Schistosoma mansoni opsin-like receptor 0.0435 0.0504 0.0646
Onchocerca volvulus Neuropeptide F receptor homolog 0.0435 0.0504 0.4187
Loa Loa (eye worm) hypothetical protein 0.0069 0.0019 0.0056
Schistosoma mansoni biogenic amine receptor 0.0435 0.0504 0.0646
Trichomonas vaginalis AGC family protein kinase 0.0166 0.0147 0.0827
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Trypanosoma cruzi cyclin, putative 0.0453 0.0528 1
Schistosoma mansoni biogenic amine receptor 0.0435 0.0504 0.0646
Echinococcus multilocularis G protein coupled receptor 139 0.06 0.0724 0.0722
Brugia malayi hypothetical protein 0.0435 0.0504 0.1674
Giardia lamblia High cysteine membrane protein Group 2 0.0678 0.0827 1
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Schistosoma mansoni alpha-1 adrenergic receptor 0.0435 0.0504 0.0646
Schistosoma mansoni biogenic amine receptor 0.0435 0.0504 0.0646
Loa Loa (eye worm) hypothetical protein 0.008 0.0033 0.0104
Schistosoma mansoni site-1 peptidase (S08 family) 0.0111 0.0075 0.0096
Loa Loa (eye worm) hypothetical protein 0.096 0.1201 0.3998
Echinococcus multilocularis rhodopsin orphan GPCR 0.0435 0.0504 0.0502
Echinococcus granulosus dnaJ subfamily B 0.5936 0.7809 0.7808
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.0596 0.3577
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0112 0.061
Echinococcus granulosus tm gpcr rhodopsin 0.0435 0.0504 0.0502
Onchocerca volvulus 0.008 0.0033 0.026
Echinococcus granulosus cyclin dependent kinase 5 0.014 0.0112 0.011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Brugia malayi PAN domain containing protein 0.008 0.0033 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.0596 0.3577
Brugia malayi Tachykinin-like peptides receptor 99D 0.2312 0.2997 0.9988
Toxoplasma gondii AGC kinase 0.0156 0.0134 0.1387
Schistosoma mansoni opsin-like receptor 0.0435 0.0504 0.0646
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0131 0.0167
Echinococcus granulosus cyclins 0.022 0.0219 0.0217
Echinococcus multilocularis neuropeptide Y receptor 0.0435 0.0504 0.0502
Trypanosoma cruzi CYC2-like cyclin, putative 0.0453 0.0528 1
Echinococcus multilocularis tubulin beta 1 chain 0.0088 0.0044 0.0042
Echinococcus multilocularis enteropeptidase 0.0153 0.0131 0.0129
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0067 0.0016 0.002
Brugia malayi hypothetical protein 0.0435 0.0504 0.1674
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0131 0.0167
Brugia malayi Protein kinase domain containing protein 0.0166 0.0147 0.0484
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0131 0.0167
Echinococcus granulosus g protein coupled receptor 0.0435 0.0504 0.0502
Toxoplasma gondii beta-1 tubulin, putative 0.0088 0.0044 0.0151
Schistosoma mansoni hypothetical protein 0.5936 0.7809 1
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Loa Loa (eye worm) hypothetical protein 0.0153 0.0131 0.0428
Echinococcus multilocularis cyclin dependent kinase 0.014 0.0112 0.011
Brugia malayi endoprotease bli-4 precursor 0.2315 0.3 1
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0111 0.0075 0.0242
Echinococcus multilocularis laminin 0.0097 0.0056 0.0054
Schistosoma mansoni hypothetical protein 0.0165 0.0146 0.0187
Loa Loa (eye worm) hypothetical protein 0.0101 0.0061 0.0197
Onchocerca volvulus 0.096 0.1201 1
Loa Loa (eye worm) trypsin family protein 0.0153 0.0131 0.0428
Trichomonas vaginalis tubulin epsilon chain, putative 0.0088 0.0044 0.0194
Trypanosoma cruzi cdc2-related kinase 1 0.014 0.0112 0.1402
Toxoplasma gondii subtilisin SUB2 0.0111 0.0075 0.0571
Loa Loa (eye worm) PAN domain-containing protein 0.008 0.0033 0.0104
Brugia malayi p70 ribosomal S6 kinase beta 0.0156 0.0134 0.0439
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.0596 0.3577
Brugia malayi hypothetical protein 0.0435 0.0504 0.1674
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Schistosoma mansoni tyrosine kinase 0.0259 0.0271 0.0348
Schistosoma mansoni amine GPCR 0.0435 0.0504 0.0646
Loa Loa (eye worm) TK/ROR protein kinase 0.0442 0.0514 0.1706
Echinococcus granulosus cyclins 0.022 0.0219 0.0217
Brugia malayi Furin-like cysteine rich region family protein 0.0259 0.0271 0.0898
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0504 0.0596 0.3577
Schistosoma mansoni serine/threonine protein kinase 0.014 0.0112 0.0144
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0094 0.0051 0.0164
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0111 0.0075 0.0441
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0435 0.0504 0.0502
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.1293 0.1644 0.1642
Brugia malayi Trypsin family protein 0.0153 0.0131 0.0428
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.0596 0.3577
Brugia malayi GnHR receptor homolog 0.1328 0.1691 0.5632
Schistosoma mansoni biogenic amine (5HT) receptor 0.0435 0.0504 0.0646
Echinococcus granulosus peptide allatostatin:somatostatin 0.0435 0.0504 0.0502
Brugia malayi Dopamine receptor 0.0435 0.0504 0.1674
Trichomonas vaginalis cyclins, putative 0.0286 0.0307 0.1804
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0111 0.0075 0.0073
Loa Loa (eye worm) hypothetical protein 0.0069 0.0019 0.0056
Loa Loa (eye worm) hypothetical protein 0.0136 0.0107 0.0349
Loa Loa (eye worm) hypothetical protein 0.0153 0.0131 0.0428
Brugia malayi ORL1-like opioid receptor 0.0435 0.0504 0.1674
Brugia malayi beta-tubulin, identical 0.0088 0.0044 0.014
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0101 0.0061 0.0197
Schistosoma mansoni tubulin subunit beta 0.0088 0.0044 0.0057
Echinococcus multilocularis 0.1811 0.2331 0.233
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0112 0.061
Brugia malayi SWIRM domain containing protein 0.0073 0.0023 0.007
Echinococcus granulosus cathepsin b 0.0138 0.011 0.0108
Onchocerca volvulus 0.0435 0.0504 0.4187
Echinococcus multilocularis caspase 2 0.0133 0.0104 0.0102
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0435 0.0504 0.1674
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0435 0.0504 0.0646
Entamoeba histolytica cyclin, putative 0.0453 0.0528 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0088 0.0044 0.0042
Schistosoma mansoni furin-1 (S08 family) 0.1133 0.1432 0.1833
Echinococcus granulosus serotonin receptor 0.0435 0.0504 0.0502
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0075 0.0381
Echinococcus granulosus membrane bound transcription factor site 1 0.0111 0.0075 0.0073
Echinococcus granulosus inhibitor of apoptosis protein 0.0136 0.0107 0.0105
Echinococcus granulosus cyclin dependent kinase 0.014 0.0112 0.011
Trichomonas vaginalis AGC family protein kinase 0.0166 0.0147 0.0827
Loa Loa (eye worm) PAN domain-containing protein 0.008 0.0033 0.0104
Echinococcus multilocularis neuropeptide receptor 0.06 0.0724 0.0722
Loa Loa (eye worm) hypothetical protein 0.0071 0.0021 0.0063
Loa Loa (eye worm) hypothetical protein 0.0071 0.0021 0.0063
Echinococcus multilocularis cyclins 0.022 0.0219 0.0217
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Onchocerca volvulus 0.0111 0.0075 0.0605
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.096 0.1201 0.1538
Brugia malayi Trypsin family protein 0.0153 0.0131 0.0428
Trichomonas vaginalis tubulin gamma chain, putative 0.0088 0.0044 0.0194
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0111 0.0075 0.2957
Loa Loa (eye worm) hypothetical protein 0.0153 0.0131 0.0428
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Loa Loa (eye worm) PAN domain-containing protein 0.008 0.0033 0.0104
Echinococcus granulosus biogenic amine 5HT receptor 0.0435 0.0504 0.0502
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Echinococcus multilocularis beta tubulin 0.0088 0.0044 0.0042
Onchocerca volvulus 0.0435 0.0504 0.4187
Echinococcus multilocularis cyclin dependent kinase 1 0.014 0.0112 0.011
Brugia malayi putative neuropeptide receptor NPR1 0.0435 0.0504 0.1674
Onchocerca volvulus 0.0435 0.0504 0.4187
Echinococcus multilocularis cyclins 0.022 0.0219 0.0217
Echinococcus multilocularis rhodopsin orphan GPCR 0.0435 0.0504 0.0502
Schistosoma mansoni hypothetical protein 0.0165 0.0146 0.0187
Echinococcus granulosus enteropeptidase 0.0153 0.0131 0.0129
Trypanosoma brucei mitotic cyclin 6 0.0453 0.0528 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0435 0.0504 0.0646
Echinococcus multilocularis neuropeptide FF receptor 2 0.2312 0.2997 0.2995
Schistosoma mansoni neuropeptide receptor 0.0435 0.0504 0.0646
Schistosoma mansoni neuropeptide receptor 0.0435 0.0504 0.0646
Schistosoma mansoni cyclin B 0.0453 0.0528 0.0677
Loa Loa (eye worm) hypothetical protein 0.0071 0.0021 0.0063
Trichomonas vaginalis cyclins, putative 0.0453 0.0528 0.3162
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0435 0.0504 0.0646
Loa Loa (eye worm) hypothetical protein 0.0453 0.0528 0.1755
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1293 0.1644 1
Brugia malayi PAN domain containing protein 0.008 0.0033 0.0104
Trichomonas vaginalis cyclin B, putative 0.0453 0.0528 0.3162
Echinococcus multilocularis Furin 1 0.0665 0.081 0.0808
Loa Loa (eye worm) hypothetical protein 0.008 0.0033 0.0104
Echinococcus granulosus g-protein coupled receptor 0.0435 0.0504 0.0502
Onchocerca volvulus 0.0435 0.0504 0.4187
Trichomonas vaginalis cyclin D, putative 0.022 0.0219 0.1264
Brugia malayi hypothetical protein 0.0435 0.0504 0.1674
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0435 0.0504 0.0502
Loa Loa (eye worm) peptidase family M13 containing protein 0.0069 0.0019 0.0056
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0435 0.0504 0.1674
Loa Loa (eye worm) hypothetical protein 0.0094 0.0051 0.0164
Echinococcus granulosus tachykinin peptides receptor 99D 0.0435 0.0504 0.0502
Brugia malayi Cyclin, N-terminal domain containing protein 0.0453 0.0528 0.1755
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0153 0.0131 0.0129
Echinococcus multilocularis fmrfamide receptor 0.0435 0.0504 0.0502
Echinococcus multilocularis rhodopsin orphan GPCR 0.0435 0.0504 0.0502
Brugia malayi PAN domain containing protein 0.008 0.0033 0.0104
Brugia malayi hypothetical protein 0.0112 0.0075 0.0243
Echinococcus granulosus neuropeptide Y receptor 0.0435 0.0504 0.0502
Brugia malayi G-protein coupled receptor 0.0435 0.0504 0.1674
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0435 0.0504 0.0502
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Echinococcus granulosus nervana 2 0.0102 0.0062 0.006
Schistosoma mansoni caspase-7 (C14 family) 0.0133 0.0104 0.0133
Echinococcus granulosus rhodopsin orphan GPCR 0.0435 0.0504 0.0502
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0435 0.0504 0.0646
Echinococcus multilocularis Tubulin beta 2C chain 0.0088 0.0044 0.0042
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0435 0.0504 0.1674
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0111 0.0075 1
Brugia malayi PAN domain containing protein 0.008 0.0033 0.0104
Schistosoma mansoni neuropeptide f receptor 76f 0.0435 0.0504 0.0646
Loa Loa (eye worm) beta-tubulin 0.0088 0.0044 0.014
Trichomonas vaginalis cyclin B, putative 0.0453 0.0528 0.3162
Echinococcus multilocularis g-protein coupled receptor 0.0435 0.0504 0.0502
Loa Loa (eye worm) PAN domain-containing protein 0.008 0.0033 0.0104
Toxoplasma gondii beta-tubulin, putative 0.0088 0.0044 0.0151
Plasmodium vivax subtilisin-like protease 2, putative 0.0111 0.0075 0.0648
Echinococcus multilocularis tissue type plasminogen activator 0.0442 0.0514 0.0512
Loa Loa (eye worm) TYRA-2 protein 0.0435 0.0504 0.1674
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Loa Loa (eye worm) melatonin receptor type 1A 0.0435 0.0504 0.1674
Onchocerca volvulus Arrow homolog 0.0101 0.0061 0.0492
Loa Loa (eye worm) hypothetical protein 0.008 0.0033 0.0104
Toxoplasma gondii subtilisin SUB12 0.0192 0.0181 0.2039
Trichomonas vaginalis cyclins, putative 0.022 0.0219 0.1264
Plasmodium vivax subtilisin-like serine protease, putative 0.0111 0.0075 0.0648
Echinococcus multilocularis Mastin 0.0153 0.0131 0.0129
Trichomonas vaginalis cyclins, putative 0.0453 0.0528 0.3162
Loa Loa (eye worm) hypothetical protein 0.0153 0.0131 0.0428
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.2315 0.3 0.3842
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0131 0.0167
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0138 0.011 0.0141
Schistosoma mansoni tubulin subunit beta 0.0088 0.0044 0.0057
Echinococcus granulosus Tubulin beta 2C chain 0.0088 0.0044 0.0042
Brugia malayi PAN domain containing protein 0.008 0.0033 0.0104
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0136 0.0107 0.0105
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0114 0.0079 0.071
Onchocerca volvulus 0.008 0.0033 0.026
Giardia lamblia Kinase, CMGC CDK 0.014 0.0112 0.0867
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0102 0.0062 0.006
Echinococcus granulosus G protein coupled receptor 139 0.0435 0.0504 0.0502
Loa Loa (eye worm) hypothetical protein 0.2312 0.2997 0.9988
Schistosoma mansoni hypothetical protein 0.0153 0.0131 0.0167
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0435 0.0504 0.0502
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0136 0.0107 0.0137
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0111 0.0075 0.0441
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.0596 0.3577
Echinococcus granulosus allatostatin A receptor 0.0435 0.0504 0.0502
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.0596 0.3577
Echinococcus granulosus neuropeptide Y receptor 0.0435 0.0504 0.0502
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0435 0.0504 0.1674
Echinococcus multilocularis cathepsin b 0.0138 0.011 0.0108
Giardia lamblia Cyclin A 0.022 0.0219 0.2231
Entamoeba histolytica protein kinase, putative 0.0166 0.0147 0.2131
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0097 0.0056 0.018
Loa Loa (eye worm) hypothetical protein 0.0136 0.0107 0.0349
Loa Loa (eye worm) hypothetical protein 0.0138 0.011 0.0359
Echinococcus granulosus cyclins 0.022 0.0219 0.0217
Echinococcus multilocularis rhodopsin orphan GPCR 0.0435 0.0504 0.0502
Loa Loa (eye worm) hypothetical protein 0.0067 0.0016 0.0045
Entamoeba histolytica cell division protein kinase 2, putative 0.014 0.0112 0.1402
Giardia lamblia G2/mitotic-specific cyclin B 0.0453 0.0528 0.6187
Echinococcus multilocularis rhodopsin orphan GPCR 0.0435 0.0504 0.0502
Loa Loa (eye worm) hypothetical protein 0.0097 0.0056 0.018
Onchocerca volvulus CoRest homolog 0.0166 0.0148 0.1216
Loa Loa (eye worm) PAN domain-containing protein 0.008 0.0033 0.0104
Echinococcus granulosus cyclin B3 1 0.022 0.0219 0.0217
Echinococcus multilocularis membrane bound transcription factor site 1 0.0111 0.0075 0.0073
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.7586 1 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0075 0.0243
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Loa Loa (eye worm) hypothetical protein 0.0233 0.0236 0.0781
Toxoplasma gondii PAN domain-containing protein 0.0626 0.0758 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Plasmodium vivax protein kinase Crk2 0.014 0.0112 0.1446
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.1293 0.1644 0.1642
Brugia malayi neuropeptide F receptor 0.0435 0.0504 0.1674
Echinococcus granulosus rhodopsin orphan GPCR 0.0435 0.0504 0.0502
Echinococcus multilocularis rhodopsin orphan GPCR 0.0435 0.0504 0.0502
Schistosoma mansoni opsin-like receptor 0.0435 0.0504 0.0646
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.022 0.0219 0.0217
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0435 0.0504 0.0502
Plasmodium falciparum cyclin 0.022 0.0219 0.3719
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Onchocerca volvulus 0.008 0.0033 0.026
Brugia malayi Subtilase family protein 0.0111 0.0075 0.0242
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0153 0.0131 0.0167
Echinococcus granulosus fmrfamide receptor 0.0435 0.0504 0.0502
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0094 0.0051 0.0066
Schistosoma mansoni serine/threonine protein kinase 0.014 0.0112 0.0144
Onchocerca volvulus 0.0435 0.0504 0.4187
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0435 0.0504 0.0646
Onchocerca volvulus 0.008 0.0033 0.026
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Echinococcus granulosus tubulin subunit beta 0.0088 0.0044 0.0042
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0115 0.008 0.0734
Loa Loa (eye worm) hypothetical protein 0.2315 0.3 1
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Loa Loa (eye worm) hypothetical protein 0.0071 0.0021 0.0063
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.014 0.0112 0.0367
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0104 0.0065 0.0431
Loa Loa (eye worm) hypothetical protein 0.1071 0.1349 0.4493
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0104 0.0065 0.0445
Brugia malayi hypothetical protein 0.0435 0.0504 0.1674
Loa Loa (eye worm) TK/EGFR protein kinase 0.0259 0.0271 0.0898
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0153 0.0131 0.0167
Echinococcus multilocularis g protein coupled receptor 0.0435 0.0504 0.0502
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0435 0.0504 0.0502
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0136 0.0107 0.0349
Echinococcus multilocularis neuropeptide Y receptor 0.0435 0.0504 0.0502
Loa Loa (eye worm) hypothetical protein 0.0453 0.0528 0.1755
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0665 0.081 0.4886
Trichomonas vaginalis hypothetical protein 0.0504 0.0596 0.3577
Loa Loa (eye worm) peptidase family M13 containing protein 0.0069 0.0019 0.0056
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Loa Loa (eye worm) hypothetical protein 0.0067 0.0016 0.0045
Trichomonas vaginalis tubulin, putative 0.0088 0.0044 0.0194
Onchocerca volvulus 0.0435 0.0504 0.4187
Schistosoma mansoni hypothetical protein 0.0435 0.0504 0.0646
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0435 0.0504 0.0502
Trypanosoma cruzi cyclin 6, putative 0.0453 0.0528 1
Echinococcus granulosus Glutaredoxin protein 5 0.0102 0.0062 0.006
Echinococcus multilocularis neuroendocrine convertase 2 0.1687 0.2166 0.2165
Loa Loa (eye worm) endoprotease bli-4 0.2315 0.3 1
Onchocerca volvulus 0.0453 0.0528 0.4389
Echinococcus granulosus Mastin 0.0153 0.0131 0.0129
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0435 0.0504 0.0502
Trichomonas vaginalis cyclin A, putative 0.0453 0.0528 0.3162
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0111 0.0075 0.2957
Brugia malayi G protein-coupled receptor F59B2.13 0.0435 0.0504 0.1674
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0435 0.0504 0.0502
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0665 0.081 0.4886
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0435 0.0504 0.0502
Brugia malayi sulfakinin receptor protein 0.0435 0.0504 0.1674
Trypanosoma cruzi cdc2-related kinase 3 0.014 0.0112 0.1402
Echinococcus granulosus sex peptide receptor 0.0435 0.0504 0.0502
Trichomonas vaginalis tubulin beta chain, putative 0.0088 0.0044 0.0194
Leishmania major subtilisin-like serine peptidase 0.0111 0.0075 0.0629
Brugia malayi Dopamine receptor protein 2 0.0435 0.0504 0.1674
Onchocerca volvulus 0.0442 0.0514 0.4265
Echinococcus granulosus Furin 1 0.0665 0.081 0.0808
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0435 0.0504 0.0502
Entamoeba histolytica cyclin family protein 0.022 0.0219 0.3605
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Schistosoma mansoni hypothetical protein 0.0435 0.0504 0.0646
Trichomonas vaginalis cyclin B, putative 0.0453 0.0528 0.3162
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0075 0.0381
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.014 0.0112 0.1087
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0161 0.014 0.018
Schistosoma mansoni neuropeptide receptor 0.06 0.0724 0.0927
Schistosoma mansoni cyclin B3 0.022 0.0219 0.028
Echinococcus granulosus nervana 2 0.0102 0.0062 0.006
Echinococcus multilocularis dnaJ subfamily B 0.5936 0.7809 0.7808
Loa Loa (eye worm) hypothetical protein 0.0069 0.0019 0.0056
Trichomonas vaginalis AGC family protein kinase 0.0166 0.0147 0.0827
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0101 0.0061 0.0078
Echinococcus granulosus laminin 0.0097 0.0056 0.0054
Echinococcus granulosus geminin 0.0165 0.0146 0.0144
Echinococcus multilocularis inhibitor of apoptosis protein 0.0136 0.0107 0.0105
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0435 0.0504 0.0646
Brugia malayi Peptidase family M13 containing protein 0.0094 0.0051 0.0164
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0435 0.0504 0.1674
Brugia malayi AKH receptor 0.0435 0.0504 0.1674
Echinococcus multilocularis dro:myosuppressin receptor 0.0435 0.0504 0.0502
Brugia malayi neuroendocrine convertase 1 precursor 0.1999 0.2582 0.8604
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Brugia malayi Kringle domain containing protein 0.0442 0.0514 0.1706
Brugia malayi proprotein convertase 2 0.1687 0.2166 0.7218
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.014 0.0112 0.011
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0138 0.011 0.0141
Onchocerca volvulus 0.0153 0.0131 0.107
Brugia malayi celfurPC protein 0.1811 0.2331 0.7768
Brugia malayi PAN domain containing protein 0.008 0.0033 0.0104
Schistosoma mansoni tubulin subunit beta 0.0088 0.0044 0.0057
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0665 0.081 0.4886
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0435 0.0504 0.1674
Onchocerca volvulus 0.0112 0.0075 0.0609
Brugia malayi Protein kinase domain containing protein 0.0442 0.0514 0.1706
Schistosoma mansoni myosin xvIII 0.0435 0.0504 0.0646
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0435 0.0504 0.0646
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0075 0.0381
Echinococcus multilocularis Tubulin beta 2C chain 0.0088 0.0044 0.0042
Schistosoma mansoni adenoreceptor 0.0435 0.0504 0.0646
Echinococcus multilocularis cyclins 0.022 0.0219 0.0217
Onchocerca volvulus 0.008 0.0033 0.026
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0138 0.011 0.0141
Onchocerca volvulus 0.008 0.0033 0.026
Echinococcus multilocularis apoptotic protease activating factor 1 0.0112 0.0075 0.0073
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0136 0.0107 0.0105
Schistosoma mansoni egf-like domain protein 0.0097 0.0056 0.0072
Schistosoma mansoni serine/threonine-protein kinase 0.0114 0.0079 0.0101
Echinococcus granulosus serine/threonine protein kinase 0.0114 0.0079 0.0077
Echinococcus multilocularis orexin receptor type 2 0.0435 0.0504 0.0502
Schistosoma mansoni site-1 peptidase (S08 family) 0.0111 0.0075 0.0096
Loa Loa (eye worm) hypothetical protein 0.0137 0.0109 0.0355
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0136 0.0107 0.0349
Loa Loa (eye worm) G-protein coupled receptor 0.0435 0.0504 0.1674
Schistosoma mansoni neuropeptide F-like receptor 0.0435 0.0504 0.0646
Trichomonas vaginalis cyclin D, putative 0.022 0.0219 0.1264
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0111 0.0075 0.2957
Echinococcus granulosus G2:mitotic specific cyclin B3 0.022 0.0219 0.0217
Onchocerca volvulus 0.0073 0.0024 0.0185
Loa Loa (eye worm) hypothetical protein 0.0362 0.0408 0.1353
Brugia malayi Fibulin-1 precursor 0.0097 0.0056 0.018
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0435 0.0504 0.0646
Brugia malayi RE15519p 0.0435 0.0504 0.1674
Brugia malayi hypothetical protein 0.0435 0.0504 0.1674
Echinococcus multilocularis cyclin B3 1 0.022 0.0219 0.0217
Echinococcus granulosus Tubulin beta 2C chain 0.0088 0.0044 0.0042
Echinococcus granulosus lysine specific histone demethylase 1A 0.0067 0.0016 0.0014
Brugia malayi Cyclin, N-terminal domain containing protein 0.0453 0.0528 0.1755
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0453 0.0528 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0435 0.0504 0.0646
Echinococcus granulosus neuropeptide s receptor 0.0435 0.0504 0.0502
Loa Loa (eye worm) hypothetical protein 0.0435 0.0504 0.1674
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0075 0.0381
Echinococcus multilocularis cyclin dependent kinase 5 0.014 0.0112 0.011
Trypanosoma brucei cdc2-related kinase 3 0.014 0.0112 0.1402
Brugia malayi Trypsin family protein 0.096 0.1201 0.3998
Brugia malayi Myb-like DNA-binding domain containing protein 0.0162 0.0142 0.0465
Schistosoma mansoni biogenic amine (5HT) receptor 0.0435 0.0504 0.0646
Mycobacterium leprae Possible secreted protease 0.0111 0.0075 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0665 0.081 0.4886
Echinococcus granulosus cyclins 0.022 0.0219 0.0217
Toxoplasma gondii subtilisin SUB8 0.0111 0.0075 0.0571
Trichomonas vaginalis tubulin alpha chain, putative 0.0088 0.0044 0.0194
Brugia malayi Cyclin, N-terminal domain containing protein 0.022 0.0219 0.0722
Toxoplasma gondii subtilisin SUB9 0.0111 0.0075 0.0571
Toxoplasma gondii subtilisin SUB6 0.0111 0.0075 0.0571
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0138 0.011 0.1355
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.0596 0.3577
Echinococcus multilocularis cyclins 0.022 0.0219 0.0217

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.064 uM Inhibitory activity against Caspase-1 using Ac-TyrValAlaAsp-amc as substrate ChEMBL. 9873617
IC50 (binding) = 0.064 uM Inhibitory activity against Caspase-1 using Ac-TyrValAlaAsp-amc as substrate ChEMBL. 9873617
IC50 (binding) = 47 uM Inhibitory activity against human Caspase-3 using Ac-AspGluValAsp as substrate ChEMBL. 9873617
IC50 (binding) = 47 uM Inhibitory activity against human Caspase-3 using Ac-AspGluValAsp as substrate ChEMBL. 9873617

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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