Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0128 | 0.1133 | 0.1053 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0517 | 0.6614 | 0.6542 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0128 | 0.1133 | 0.1053 |
Loa Loa (eye worm) | hypothetical protein | 0.0758 | 1 | 1 |
Onchocerca volvulus | 0.0128 | 0.1133 | 0.1675 | |
Loa Loa (eye worm) | carboxylesterase | 0.0128 | 0.1133 | 0.0946 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0758 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0338 | 0.4095 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.3055 | 0.2908 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.6319 | 0.6241 |
Loa Loa (eye worm) | carboxylesterase | 0.0758 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0128 | 0.1133 | 0.1053 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1133 | 0.0946 |
Echinococcus granulosus | acetylcholinesterase | 0.0758 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0128 | 0.1133 | 0.0946 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0128 | 0.1133 | 0.5 |
Echinococcus granulosus | neuropeptide s receptor | 0.0517 | 0.6614 | 0.6181 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0338 | 0.4095 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0128 | 0.1133 | 0.5 |
Brugia malayi | hypothetical protein | 0.0496 | 0.6319 | 0.6285 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0338 | 0.4095 | 1 |
Onchocerca volvulus | 0.0128 | 0.1133 | 0.1675 | |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0128 | 0.1133 | 0.1053 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0517 | 0.6614 | 0.6181 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0058 | 0.0147 | 0.0358 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0128 | 0.1133 | 0.1053 |
Echinococcus granulosus | acetylcholinesterase | 0.0758 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1133 | 0.0946 |
Schistosoma mansoni | acetylcholinesterase | 0.0128 | 0.1133 | 0.1053 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0758 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0128 | 0.1133 | 0.1053 |
Onchocerca volvulus | 0.0128 | 0.1133 | 0.1675 | |
Leishmania major | mitochondrial DNA polymerase beta | 0.0338 | 0.4095 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0128 | 0.1133 | 0.1053 |
Schistosoma mansoni | gliotactin | 0.0128 | 0.1133 | 0.1053 |
Onchocerca volvulus | 0.0128 | 0.1133 | 0.1675 | |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1133 | 0.0946 |
Mycobacterium ulcerans | hypothetical protein | 0.0178 | 0.184 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0517 | 0.6614 | 0.6542 |
Echinococcus multilocularis | neuroligin | 0.0128 | 0.1133 | 0.0946 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0128 | 0.1133 | 0.1053 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1133 | 0.0946 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0265 | 0.3055 | 0.2908 |
Echinococcus multilocularis | acetylcholinesterase | 0.0758 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0758 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0758 | 1 | 1 |
Onchocerca volvulus | 0.0128 | 0.1133 | 0.1675 | |
Loa Loa (eye worm) | carboxylesterase | 0.0128 | 0.1133 | 0.0946 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.016 | 0.1585 | 0.3871 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0265 | 0.3055 | 0.2167 |
Echinococcus multilocularis | acetylcholinesterase | 0.0758 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1133 | 0.0946 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0128 | 0.1133 | 0.0946 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.6319 | 0.6241 |
Brugia malayi | Carboxylesterase family protein | 0.0128 | 0.1133 | 0.1053 |
Brugia malayi | Carboxylesterase family protein | 0.0128 | 0.1133 | 0.1053 |
Onchocerca volvulus | 0.0496 | 0.6319 | 1 | |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.016 | 0.1585 | 0.3871 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1133 | 0.0946 |
Loa Loa (eye worm) | hypothetical protein | 0.0758 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0178 | 0.184 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0055 | 0.0099 | 0.5 |
Schistosoma mansoni | lozenge | 0.0062 | 0.0207 | 0.0118 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0128 | 0.1133 | 0.0946 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1133 | 0.0946 |
Brugia malayi | Carboxylesterase family protein | 0.0758 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0265 | 0.3055 | 0.2992 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.5131 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.