Detailed information for compound 1531491

Basic information

Technical information
  • TDR Targets ID: 1531491
  • Name: 2-(4-methoxyphenoxy)-N-(2H-1,2,4-triazol-3-yl )acetamide
  • MW: 248.238 | Formula: C11H12N4O3
  • H donors: 2 H acceptors: 3 LogP: 0.65 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)OCC(=O)Nc1nnc[nH]1
  • InChi: 1S/C11H12N4O3/c1-17-8-2-4-9(5-3-8)18-6-10(16)14-11-12-7-13-15-11/h2-5,7H,6H2,1H3,(H2,12,13,14,15,16)
  • InChiKey: PARGTTNKDPLSDD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-methoxyphenoxy)-N-(2H-1,2,4-triazol-3-yl)ethanamide
  • Oprea1_263089
  • Oprea1_123261
  • 2-(4-Methoxy-phenoxy)-N-(4H-[1,2,4]triazol-3-yl)-acetamide
  • IBS-0003222
  • BAS 01319154
  • STK325264
  • AF-399/13567027
  • ZINC00087065

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens alkaline phosphatase, liver/bone/kidney Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis intestinal type alkaline phosphatase 1 Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus granulosus intestinal type alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus multilocularis alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus granulosus intestinal type alkaline phosphatase 1 Get druggable targets OG5_126976 All targets in OG5_126976
Candida albicans alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus granulosus alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 Get druggable targets OG5_126976 All targets in OG5_126976
Candida albicans vacuolar alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma japonicum ko:K01077 alkaline phosphatase [EC3.1.3.1], putative Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma mansoni hypothetical protein Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma japonicum Alkaline phosphatase, tissue-nonspecific isozyme precursor, putative Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma mansoni alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus granulosus alkaline phosphatase intestinal gene 2 Get druggable targets OG5_126976 All targets in OG5_126976
Candida albicans vacuolar alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus multilocularis intestinal type alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma mansoni alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Candida albicans alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0368 0.0296
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0474 0.0904
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0368 0.0296
Entamoeba histolytica hypothetical protein 0.0038 0.0364 1
Brugia malayi Carboxylesterase family protein 0.0619 0.9589 1
Leishmania major cathepsin L-like protease 0.0068 0.083 0.1643
Loa Loa (eye worm) agrin synaptic family protein 0.004 0.0397 0.0414
Echinococcus multilocularis agrin 0.004 0.0397 0.0376
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.012 0.1666 0.1704
Echinococcus multilocularis carboxylesterase 5A 0.0619 0.9589 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0039 0.004
Brugia malayi Cathepsin L-like precursor 0.0018 0.0039 0.004
Brugia malayi intermediate filament protein 0.0029 0.0211 0.022
Toxoplasma gondii ABC1 family protein 0.0038 0.0368 0.5025
Brugia malayi Carboxylesterase family protein 0.012 0.1666 0.1737
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.083 0.1643
Loa Loa (eye worm) hypothetical protein 0.0038 0.0368 0.0384
Echinococcus granulosus family S9 non peptidase ue S09 family 0.012 0.1666 0.1704
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.012 0.1666 0.1603
Trichomonas vaginalis spcc417.12 protein, putative 0.012 0.1666 1
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0368 0.0615
Loa Loa (eye worm) carboxylesterase 0.012 0.1666 0.1737
Brugia malayi sodium-independent organic anion transporter family protein 0.0059 0.0695 0.0725
Echinococcus multilocularis para nitrobenzyl esterase 0.012 0.1666 0.1704
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.083 0.158
Loa Loa (eye worm) hypothetical protein 0.0059 0.0695 0.0725
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0074 0.0074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0534 0.0518
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0368 0.2027
Loa Loa (eye worm) hypothetical protein 0.0059 0.0695 0.0725
Brugia malayi sodium-independent organic anion transporter family protein 0.0059 0.0695 0.0725
Loa Loa (eye worm) hypothetical protein 0.0059 0.0695 0.0725
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0368 0.2027
Onchocerca volvulus 0.012 0.1666 1
Echinococcus granulosus intermediate filament protein 0.0029 0.0211 0.018
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0321 0.4855 1
Brugia malayi Carboxylesterase family protein 0.012 0.1666 0.1737
Schistosoma mansoni BC026374 protein (S09 family) 0.012 0.1666 0.1704
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0534 0.0518
Entamoeba histolytica hypothetical protein 0.0038 0.0364 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0368 0.0685
Entamoeba histolytica hypothetical protein 0.0038 0.0364 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.083 0.158
Brugia malayi Carboxylesterase family protein 0.0619 0.9589 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.012 0.1666 0.1704
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0364 0.0341
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.2442 0.2385
Onchocerca volvulus 0.012 0.1666 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0534 0.0557
Echinococcus multilocularis acetylcholinesterase 0.0619 0.9589 1
Mycobacterium ulcerans beta-lactamase 0.0038 0.0368 0.0296
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0059 0.0695 0.0687
Echinococcus multilocularis muscleblind protein 1 0.0318 0.4815 0.5001
Onchocerca volvulus 0.0059 0.0695 0.4033
Mycobacterium leprae Probable lipase LipE 0.0038 0.0368 0.5
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0368 1
Loa Loa (eye worm) cysteine protease 0.0018 0.0039 0.004
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0074 0.11
Brugia malayi SPARC precursor 0.004 0.0397 0.0414
Schistosoma mansoni lamin 0.0029 0.0211 0.018
Echinococcus granulosus muscleblind protein 0.0318 0.4815 0.5001
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0368 0.5
Loa Loa (eye worm) hypothetical protein 0.012 0.1666 0.1737
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0211 0.022
Toxoplasma gondii hypothetical protein 0.0052 0.0579 0.8238
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0534 0.0518
Leishmania major hypothetical protein, conserved 0.0038 0.0368 0.0685
Loa Loa (eye worm) hypothetical protein 0.004 0.0397 0.0414
Onchocerca volvulus 0.0059 0.0695 0.4033
Schistosoma mansoni intermediate filament proteins 0.0029 0.0211 0.018
Echinococcus multilocularis lamin 0.0029 0.0211 0.018
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0737 0.145
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.083 0.158
Onchocerca volvulus 0.012 0.1666 1
Echinococcus granulosus lamin dm0 0.0029 0.0211 0.018
Echinococcus granulosus alkaline phosphatase 0.0196 0.2876 0.2971
Schistosoma mansoni organic anion transporter 0.0059 0.0695 0.0687
Loa Loa (eye worm) hypothetical protein 0.0059 0.0695 0.0725
Echinococcus multilocularis musashi 0.0029 0.0211 0.018
Schistosoma mansoni acetylcholinesterase 0.012 0.1666 0.1704
Onchocerca volvulus 0.0059 0.0695 0.4033
Brugia malayi Cathepsin L-like precursor 0.0018 0.0039 0.004
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0368 0.0384
Onchocerca volvulus 0.0038 0.0368 0.2027
Mycobacterium ulcerans hypothetical protein 0.0169 0.2442 0.2385
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.004 0.0397 0.0414
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0196 0.2876 0.2971
Mycobacterium tuberculosis Conserved protein 0.0038 0.0368 0.0296
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0368 0.0296
Echinococcus granulosus agrin 0.004 0.0397 0.0376
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0074 0.0038
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0039 0.004
Toxoplasma gondii exonuclease III APE 0.002 0.0074 0.0546
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.083 0.158
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0074 0.0074
Echinococcus granulosus BC026374 protein S09 family 0.012 0.1666 0.1704
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0368 0.2027
Toxoplasma gondii protease inhibitor PI2 0.004 0.0397 0.5466
Onchocerca volvulus 0.0029 0.0211 0.1057
Onchocerca volvulus 0.0059 0.0695 0.4033
Mycobacterium ulcerans hypothetical protein 0.0038 0.0368 0.0296
Mycobacterium tuberculosis Carboxylesterase LipT 0.0266 0.3979 0.3934
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0211 0.022
Loa Loa (eye worm) hypothetical protein 0.004 0.0397 0.0414
Echinococcus multilocularis BC026374 protein (S09 family) 0.012 0.1666 0.1704
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.012 0.1666 0.1704
Onchocerca volvulus Putative organic anion transporter 0.0059 0.0695 0.4033
Schistosoma mansoni follistatin 0.004 0.0397 0.0376
Loa Loa (eye worm) ctsf protein 0.0018 0.0039 0.004
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0321 0.4855 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.217 0.4425
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0474 0.0904
Toxoplasma gondii transporter, major facilitator family protein 0.0059 0.0695 1
Loa Loa (eye worm) hypothetical protein 0.012 0.1666 0.1737
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0074 0.0074
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0368 0.2027
Brugia malayi beta-lactamase family protein 0.0038 0.0368 0.0384
Loa Loa (eye worm) hypothetical protein 0.0619 0.9589 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.217 0.4425
Loa Loa (eye worm) hypothetical protein 0.004 0.0397 0.0414
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0321 0.4855 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0619 0.9589 1
Brugia malayi beta-lactamase family protein 0.0038 0.0368 0.0384
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0074 0.022
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.012 0.1666 0.1704
Schistosoma mansoni alkaline phosphatase 0.0196 0.2876 0.2971
Brugia malayi prostaglandin transporter 0.0059 0.0695 0.0725
Echinococcus granulosus carboxylesterase 5A 0.0619 0.9589 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0368 0.2027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.083 0.158
Echinococcus granulosus lamin 0.0029 0.0211 0.018
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0074 0.0078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.083 0.158
Echinococcus granulosus para nitrobenzyl esterase 0.012 0.1666 0.1704
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.012 0.1666 0.1704
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.083 0.158
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0074 0.5
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0074 0.0038
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0368 0.0296
Echinococcus multilocularis follistatin 0.004 0.0397 0.0376
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.083 0.158
Loa Loa (eye worm) hypothetical protein 0.0059 0.0695 0.0725
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.083 0.1643
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0364 0.0341
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0196 0.2876 0.2971
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.217 0.4383
Schistosoma mansoni ap endonuclease 0.002 0.0074 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0534 0.0518
Brugia malayi Carboxylesterase family protein 0.012 0.1666 0.1737
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.004 0.0397 0.5466
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.004 0.0397 0.5466
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0074 0.5
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0474 0.0904
Loa Loa (eye worm) hypothetical protein 0.012 0.1666 0.1737
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0368 0.0296
Brugia malayi Cathepsin L-like precursor 0.0018 0.0039 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.083 0.158
Schistosoma mansoni agrin 0.004 0.0397 0.0376
Loa Loa (eye worm) hypothetical protein 0.0038 0.0368 0.0384
Leishmania major cathepsin L-like protease 0.0068 0.083 0.1643
Leishmania major mitochondrial DNA polymerase beta 0.0321 0.4855 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0368 0.0296
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0534 0.0518
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0474 0.0835
Loa Loa (eye worm) hypothetical protein 0.0029 0.0211 0.022
Loa Loa (eye worm) hypothetical protein 0.004 0.0397 0.0414
Brugia malayi hypothetical protein 0.012 0.1666 0.1737
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.004 0.0397 0.0414
Loa Loa (eye worm) hypothetical protein 0.0038 0.0368 0.0384
Loa Loa (eye worm) carboxylesterase 0.0619 0.9589 1
Loa Loa (eye worm) hypothetical protein 0.0318 0.4815 0.5021
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.004
Echinococcus granulosus neuroligin 0.012 0.1666 0.1704
Onchocerca volvulus 0.0038 0.0368 0.2027
Echinococcus multilocularis acetylcholinesterase 0.0619 0.9589 1
Loa Loa (eye worm) hypothetical protein 0.012 0.1666 0.1737
Loa Loa (eye worm) carboxylesterase 0.012 0.1666 0.1737
Loa Loa (eye worm) beta-lactamase 0.0038 0.0368 0.0384
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.004 0.0397 0.5466
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.083 0.158
Schistosoma mansoni ap endonuclease 0.002 0.0074 0.0038
Loa Loa (eye worm) hypothetical protein 0.012 0.1666 0.1737
Onchocerca volvulus Putative organic anion transporter 0.0059 0.0695 0.4033
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0074 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0368 0.0384
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.012 0.1666 1
Entamoeba histolytica hypothetical protein 0.0038 0.0364 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0039 0.004
Mycobacterium ulcerans carboxylesterase, LipT 0.0266 0.3979 0.3934
Echinococcus granulosus follistatin 0.004 0.0397 0.0376
Schistosoma mansoni gliotactin 0.012 0.1666 0.1704
Onchocerca volvulus 0.012 0.1666 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0534 0.0518
Onchocerca volvulus 0.004 0.0397 0.2205
Onchocerca volvulus Putative organic anion transporter 0.0059 0.0695 0.4033
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0074 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0368 0.0296
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0196 0.2876 0.2971
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0059 0.0695 0.0725
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0368 0.0384
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0246 0.3663 0.3615
Mycobacterium ulcerans lipase LipD 0.0038 0.0368 0.0296
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0074 0.022
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0039 0.004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0368 0.0345
Loa Loa (eye worm) hypothetical protein 0.0318 0.4815 0.5021
Schistosoma mansoni lamin 0.0029 0.0211 0.018
Loa Loa (eye worm) hypothetical protein 0.0038 0.0368 0.0384
Mycobacterium ulcerans short chain dehydrogenase 0.0645 1 1
Echinococcus granulosus Solute carrier organic anion transporter family 0.0059 0.0695 0.0687
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0074 0.1087
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0211 0.022
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0534 0.0557
Loa Loa (eye worm) hypothetical protein 0.0028 0.0202 0.0211
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0368 0.0685
Loa Loa (eye worm) hypothetical protein 0.0059 0.0695 0.0725
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.06 0.1166
Trichomonas vaginalis esterase, putative 0.0038 0.0368 0.2027
Echinococcus multilocularis lamin dm0 0.0029 0.0211 0.018
Echinococcus multilocularis muscleblind protein 0.0318 0.4815 0.5001
Brugia malayi beta-lactamase 0.0038 0.0368 0.0384
Loa Loa (eye worm) hypothetical protein 0.0059 0.0695 0.0725
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0059 0.0695 0.0687
Echinococcus granulosus intestinal type alkaline phosphatase 0.0196 0.2876 0.2971
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0631 0.1229
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0074 0.0078
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.004 0.0397 0.0414
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.004 0.0397 0.0414
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.083 0.158
Onchocerca volvulus 0.0059 0.0695 0.4033
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.083 0.1643
Brugia malayi hypothetical protein 0.0038 0.0364 0.038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0534 0.0518
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.012 0.1666 0.1603
Loa Loa (eye worm) hypothetical protein 0.0619 0.9589 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0368 0.0345
Loa Loa (eye worm) hypothetical protein 0.0038 0.0368 0.0384
Loa Loa (eye worm) hypothetical protein 0.012 0.1666 0.1737
Echinococcus granulosus acetylcholinesterase 0.0619 0.9589 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0364 0.0341
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0368 0.0296
Brugia malayi Carboxylesterase family protein 0.012 0.1666 0.1737
Brugia malayi secreted modular calcium-binding protein 1 0.004 0.0397 0.0414
Loa Loa (eye worm) acetylcholinesterase 1 0.0619 0.9589 1
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0196 0.2876 0.2971
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.004 0.0397 0.0414
Schistosoma mansoni hypothetical protein 0.0038 0.0364 0.0341
Brugia malayi Muscleblind-like protein 0.0318 0.4815 0.5021
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.004 0.0397 0.5466
Echinococcus multilocularis neuroligin 0.012 0.1666 0.1704
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0368 0.0296
Echinococcus granulosus acetylcholinesterase 0.0619 0.9589 1
Onchocerca volvulus 0.0038 0.0368 0.2027
Schistosoma mansoni organic anion transporter 0.0059 0.0695 0.0687
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.083 0.1643
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0368 0.0296
Echinococcus multilocularis expressed protein 0.004 0.0397 0.0376
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0368 0.0296
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0368 0.0345
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0196 0.2876 0.2971
Brugia malayi hypothetical protein 0.0059 0.0695 0.0725
Brugia malayi hypothetical protein 0.0059 0.0695 0.0725
Brugia malayi sodium-independent organic anion transporter family protein 0.0059 0.0695 0.0725
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0039 0.004
Leishmania major cathepsin L-like protease 0.0068 0.083 0.1643
Schistosoma mansoni hypothetical protein 0.0102 0.1378 0.1402
Loa Loa (eye worm) hypothetical protein 0.012 0.1666 0.1737
Brugia malayi Cathepsin L-like precursor 0.0018 0.0039 0.004
Onchocerca volvulus 0.012 0.1666 1
Loa Loa (eye worm) fibroinase 0.0018 0.0039 0.004
Trypanosoma cruzi MFS transporter, putative 0.0059 0.0695 0.1363
Echinococcus multilocularis alkaline phosphatase 0.0196 0.2876 0.2971
Schistosoma mansoni alkaline phosphatase 0.0196 0.2876 0.2971
Onchocerca volvulus 0.0029 0.0211 0.1057
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0059 0.0695 0.0687
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0368 0.0345

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 4.7 uM PUBCHEM_BIOASSAY: SAR assay for compounds activating TNAP in the presence of 100 mM DEA performed in a luminescence assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1001, AID1056, AID1450, AID1548, AID1941, AID518, AID813] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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