Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2503 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2503 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0959 | 0.2838 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.2503 | 0.7404 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0959 | 1 |
Echinococcus granulosus | expressed protein | 0.001 | 0.0006 | 0.0018 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.338 | 1 |
Schistosoma mansoni | ferritin | 0.001 | 0.0006 | 0.0018 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.0959 | 0.5 |
Schistosoma mansoni | ferritin light chain | 0.001 | 0.0006 | 0.0018 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.338 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.338 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0959 | 0.2838 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0959 | 1 |
Schistosoma mansoni | ferritin | 0.001 | 0.0006 | 0.0018 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.2503 | 0.7404 |
Schistosoma mansoni | apoferritin-2 | 0.001 | 0.0006 | 0.0018 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.338 | 0.338 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Echinococcus multilocularis | ferritin | 0.001 | 0.0006 | 0.0018 |
Schistosoma mansoni | ferritin | 0.001 | 0.0006 | 0.0018 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.338 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0959 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.338 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.338 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.338 | 0.338 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.338 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.0959 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0959 | 0.0959 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0959 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0959 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2503 | 1 |
Echinococcus multilocularis | expressed protein | 0.001 | 0.0006 | 0.0018 |
Schistosoma mansoni | apoferritin-2 | 0.001 | 0.0006 | 0.0018 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0959 | 0.5 |
Schistosoma mansoni | ferritin | 0.001 | 0.0006 | 0.0018 |
Echinococcus granulosus | ferritin | 0.001 | 0.0006 | 0.0018 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0959 | 0.0959 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2503 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0959 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.2503 | 0.2503 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0959 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.2503 | 0.7404 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.0959 | 0.5 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.001 | 0.0006 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0959 | 0.2838 |
Schistosoma mansoni | ferritin light chain | 0.001 | 0.0006 | 0.0018 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0959 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0959 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0959 | 0.2838 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0959 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2503 | 0.7404 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1259 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 0.1413 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.5929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.