Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neuronal acetylcholine receptor; alpha4/beta2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0105 | 0.0105 |
Echinococcus granulosus | neuroligin | 0.0024 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | carboxylesterase | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0024 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | carboxylesterase | 0.0024 | 0.0105 | 0.0105 |
Onchocerca volvulus | 0.0024 | 0.0105 | 1 | |
Brugia malayi | hypothetical protein | 0.0024 | 0.0105 | 0.0105 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0105 | 0.0105 |
Echinococcus multilocularis | acetylcholinesterase | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0105 | 0.0105 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.0105 | 0.0105 |
Echinococcus granulosus | acetylcholinesterase | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0105 | 0.0105 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0024 | 0.0105 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0105 | 0.0105 |
Echinococcus multilocularis | acetylcholinesterase | 0.0141 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0024 | 0.0105 | 0.0105 |
Echinococcus granulosus | acetylcholinesterase | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0141 | 1 | 1 |
Onchocerca volvulus | 0.0024 | 0.0105 | 1 | |
Schistosoma mansoni | gliotactin | 0.0024 | 0.0105 | 0.0105 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0024 | 0.0105 | 0.5 |
Onchocerca volvulus | 0.0024 | 0.0105 | 1 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0141 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0024 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0105 | 0.0105 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0024 | 0.0105 | 0.0105 |
Onchocerca volvulus | 0.0024 | 0.0105 | 1 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0024 | 0.0105 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.0105 | 0.0105 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0024 | 0.0105 | 0.0105 |
Echinococcus granulosus | carboxylesterase 5A | 0.0141 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0024 | 0.0105 | 0.0105 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.0105 | 0.0105 |
Onchocerca volvulus | 0.0024 | 0.0105 | 1 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0024 | 0.0105 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0141 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.0105 | 0.0105 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0024 | 0.0105 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0024 | 0.0105 | 0.0105 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0024 | 0.0105 | 0.0105 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0024 | 0.0105 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0024 | 0.0105 | 0.0105 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0024 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0105 | 0.0105 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0024 | 0.0105 | 0.0105 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 63.82 nM | Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat brain synaptic membranes. | ChEMBL. | 10509928 |
Ki (binding) | = 63.82 nM | Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat brain synaptic membranes. | ChEMBL. | 10509928 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.