Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.0789 | 0.0789 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 1 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 0.461 | 0.461 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.3244 | 0.3244 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0043 | 0.0422 | 0.0422 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0422 | 0.0422 |
Brugia malayi | jmjC domain containing protein | 0.0043 | 0.0422 | 0.0422 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.0789 | 0.0789 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1444 | 0.1444 |
Echinococcus granulosus | carboxylesterase 5A | 0.0209 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0209 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.2155 | 0.2155 |
Brugia malayi | jmjC domain containing protein | 0.0115 | 0.461 | 0.461 |
Echinococcus multilocularis | acetylcholinesterase | 0.0209 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0209 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0209 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0209 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 0.461 | 0.461 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0209 | 1 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0043 | 0.0422 | 0.0422 |
Echinococcus granulosus | acetylcholinesterase | 0.0209 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0209 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.0422 | 0.0422 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0422 | 0.0422 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.