Detailed information for compound 1532089

Basic information

Technical information
  • TDR Targets ID: 1532089
  • Name: 3,6-dichloro-N-[(4,6-dimethylpyrimidin-2-yl)c arbamoyl]-2-methoxybenzamide
  • MW: 369.203 | Formula: C15H14Cl2N4O3
  • H donors: 2 H acceptors: 4 LogP: 3.56 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(Cl)ccc(c1C(=O)NC(=O)Nc1nc(C)cc(n1)C)Cl
  • InChi: 1S/C15H14Cl2N4O3/c1-7-6-8(2)19-14(18-7)21-15(23)20-13(22)11-9(16)4-5-10(17)12(11)24-3/h4-6H,1-3H3,(H2,18,19,20,21,22,23)
  • InChiKey: MWSDISYFRAFWLI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3,6-dichloro-N-[(4,6-dimethylpyrimidin-2-yl)carbamoyl]-2-methoxy-benzamide
  • 3,6-dichloro-N-[[(4,6-dimethyl-2-pyrimidinyl)amino]-oxomethyl]-2-methoxybenzamide
  • ZINC01063618

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0582 0.5
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0584 0.0366
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0582 0.5
Loa Loa (eye worm) hypothetical protein 0.0044 0.1314 0.1152
Echinococcus multilocularis RUN 0.0044 0.1314 0.1152
Echinococcus multilocularis Polycystic kidney disease protein 0.0044 0.1314 0.1152
Brugia malayi Importin beta-1 subunit 0.0028 0.0765 0.0722
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0582 0.5
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0513 0.0781
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0765 0.2453
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0235 0.0053
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0758 0.8655
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0513 0.1033
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.3113 1
Entamoeba histolytica hypothetical protein 0.0043 0.1287 0.4132
Echinococcus granulosus Polycystic kidney disease protein 0.0044 0.1314 0.1152
Loa Loa (eye worm) hypothetical protein 0.0019 0.0457 0.028
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.3113 1
Schistosoma mansoni hypothetical protein 0.0019 0.0457 0.0457
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0875 0.0875
Echinococcus multilocularis snurportin 1 0.03 1 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0765 0.8735
Plasmodium falciparum importin beta, putative 0.0028 0.0765 0.5145
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1856 0.2074
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.3113 0.3633
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0758 0.243
Schistosoma mansoni ap endonuclease 0.0023 0.0582 0.0582
Echinococcus granulosus GPCR family 2 0.0019 0.0457 0.028
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0765 0.2453
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1324 0.1324
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0765 0.0593
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0582 0.1809
Schistosoma mansoni hypothetical protein 0.0019 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.006 0.1856 0.1704
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0582 0.1362
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0582 0.0363
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.3113 1
Brugia malayi hypothetical protein 0.0028 0.0758 0.0713
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0758 0.5083
Schistosoma mansoni hypothetical protein 0.0013 0.0235 0.0235
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.3113 0.3113
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0413 0.4719
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0292 0.0935
Leishmania major importin beta-1 subunit, putative 0.0023 0.0584 0.1035
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0513 0.0336
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.3113 0.2985
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0875 0.0875
Loa Loa (eye worm) hypothetical protein 0.0028 0.0758 0.0586
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0875 0.0706
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0513 0.0336
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0457 0.028
Toxoplasma gondii exonuclease III APE 0.0023 0.0582 0.6648
Brugia malayi Pre-SET motif family protein 0.0219 0.7237 0.8746
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1324 0.1163
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1324 0.1163
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0582 0.0495
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0292 0.0939
Schistosoma mansoni lipoxygenase 0.0265 0.8805 0.8805
Plasmodium falciparum LCCL domain-containing protein 0.0044 0.1314 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.1287 0.1124
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.3113 0.2985
Schistosoma mansoni DNA helicase recq5 0.0011 0.0183 0.0183
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0513 0.2917
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3113 0.3539
Echinococcus multilocularis survival motor neuron protein 1 0.0248 0.8248 0.8216
Giardia lamblia Kinase, PLK 0.0097 0.3113 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0235 0.0053
Brugia malayi Doublecortin family protein 0.0044 0.1314 0.1402
Leishmania major GTP-binding protein, putative 0.0021 0.0513 0.0781
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0758 0.165
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1324 0.1415
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0758 0.5083
Brugia malayi Pre-SET motif family protein 0.0031 0.0875 0.0859
Entamoeba histolytica hypothetical protein 0.0023 0.0584 0.1876
Trichomonas vaginalis ran, putative 0.0021 0.0513 0.0277
Schistosoma mansoni hypothetical protein 0.03 1 1
Echinococcus granulosus RUN 0.0044 0.1314 0.1152
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0513 0.1126
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.1314 0.1152
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0457 0.028
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0582 0.1027
Schistosoma mansoni hypothetical protein 0.0051 0.1531 0.1531
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0457 0.0341
Echinococcus multilocularis GPCR, family 2 0.0019 0.0457 0.028
Schistosoma mansoni ran 0.0021 0.0513 0.0513
Loa Loa (eye worm) hypothetical protein 0.0134 0.4352 0.4247
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0513 0.5856
Schistosoma mansoni hypothetical protein 0.0019 0.0457 0.0457
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.1287 0.1124
Brugia malayi hypothetical protein 0.0043 0.1287 0.1369
Schistosoma mansoni hypothetical protein 0.0044 0.1314 0.1314
Echinococcus multilocularis bloom syndrome protein 0.0027 0.0713 0.054
Onchocerca volvulus 0.0044 0.1314 0.0594
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0582 0.0407
Echinococcus granulosus bloom syndrome protein 0.0027 0.0713 0.054
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0758 0.3776
Brugia malayi Bloom's syndrome protein homolog 0.0027 0.0713 0.0657
Trypanosoma brucei polo-like protein kinase 0.0097 0.3113 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0758 0.165
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0183 0.2086
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0513 0.0781
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0713 0.0527
Echinococcus granulosus survival motor neuron protein 1 0.0248 0.8248 0.8216
Schistosoma mansoni survival motor neuron protein 0.0051 0.1531 0.1531
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.3113 0.2985
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3113 0.3539
Brugia malayi RNA, U transporter 1 0.008 0.2524 0.2903
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0265 0.8805 0.8783
Entamoeba histolytica hypothetical protein 0.0043 0.1287 0.4132
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0457 0.028
Brugia malayi hypothetical protein 0.0018 0.0422 0.0297
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0582 0.0363
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.3113 0.3029
Loa Loa (eye worm) RecQ helicase 0.0027 0.0713 0.054
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0582 0.0407
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0582 0.1869
Onchocerca volvulus 0.0249 0.8263 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0875 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1324 0.1163
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1209 0.1272
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0265 0.8805 0.8783
Schistosoma mansoni kinase 0.0049 0.1489 0.1489
Brugia malayi hypothetical protein 0.0248 0.8248 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.1314 0.1152
Onchocerca volvulus 0.0051 0.1531 0.0888
Schistosoma mansoni hypothetical protein 0.0043 0.1287 0.1287
Brugia malayi hypothetical protein 0.0044 0.1314 0.1402
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0875 0.0875
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.1314 0.1152
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.1531 0.1672
Loa Loa (eye worm) hypothetical protein 0.0031 0.0875 0.0706
Entamoeba histolytica hypothetical protein 0.0043 0.1287 0.4132
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0875 0.0706
Schistosoma mansoni ap endonuclease 0.0023 0.0582 0.0582
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0513 0.0409
Schistosoma mansoni polycystin 1-related 0.0044 0.1314 0.1314
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1324 0.1163
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0183 0.2086
Plasmodium vivax multidomain scavenger receptor, putative 0.0044 0.1314 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0584 0.1035
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1856 0.1704
Trichomonas vaginalis DNA helicase recq1, putative 0.0027 0.0713 0.0527
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.3113 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0875 0.0706
Leishmania major hypothetical protein, conserved 0.0028 0.0758 0.165
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0513 0.1643
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0523 0.0523
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.1287 0.1287
Loa Loa (eye worm) doublecortin family protein 0.0044 0.1314 0.1152
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0836 0.0666
Schistosoma mansoni hypothetical protein 0.0019 0.0457 0.0457
Schistosoma mansoni importin beta-1 0.0028 0.0765 0.0765
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0875 0.0875
Onchocerca volvulus 0.0044 0.1314 0.0594
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0584 0.0366
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0582 0.1027
Schistosoma mansoni ran 0.0021 0.0513 0.0513
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3113 0.3539
Brugia malayi hypothetical protein 0.0044 0.1314 0.1402
Schistosoma mansoni hypothetical protein 0.0041 0.1209 0.1209
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0582 0.1027
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0457 0.0341
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0582 0.1865
Loa Loa (eye worm) hypothetical protein 0.0044 0.1314 0.1152
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.1445 0.1447
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0582 0.0407
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0457 0.028
Schistosoma mansoni lipoxygenase 0.0185 0.6098 0.6098
Plasmodium vivax SET domain protein, putative 0.0031 0.0875 0.5093
Schistosoma mansoni loxhd1 0.0044 0.1314 0.1314
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 1 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0513 0.0336
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0584 0.0366
Loa Loa (eye worm) hypothetical protein 0.0041 0.1209 0.1045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1324 0.1324
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1324 0.1324
Trichomonas vaginalis set domain proteins, putative 0.0249 0.8263 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3113 0.3539
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.1314 0.1152
Schistosoma mansoni rab6-interacting 0.0044 0.1314 0.1314
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1856 0.2074
Loa Loa (eye worm) hypothetical protein 0.0248 0.8248 0.8216
Schistosoma mansoni rab6-interacting 0.0044 0.1314 0.1314
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0457 0.028
Loa Loa (eye worm) hypothetical protein 0.0028 0.0765 0.0593
Entamoeba histolytica hypothetical protein 0.0043 0.1287 0.4132
Echinococcus granulosus importin subunit beta 1 0.0028 0.0765 0.0593
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3113 0.3539
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0582 0.353
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0603 0.3716
Schistosoma mansoni DNA helicase recq1 0.0011 0.0183 0.0183
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.7237 0.7185
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1324 0.1163
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0582 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.1445 0.1447
Plasmodium vivax importin-beta 2, putative 0.0028 0.0765 0.3854
Entamoeba histolytica Ran family GTPase 0.0021 0.0513 0.1647
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3113 0.3539
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3113 0.3539

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.4368 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.