Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 1 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 1 | 0.5 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 1 | 0.5 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 1 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 1 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 1 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 1 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 1 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 1 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 1 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 1 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0023 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 1 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 1 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0023 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.2944 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.