Detailed information for compound 1532729

Basic information

Technical information
  • TDR Targets ID: 1532729
  • Name: [2-(2,2-dimethyl-3-oxo-4H-quinoxalin-1-yl)-2- oxoethyl] pyridine-3-carboxylate
  • MW: 339.345 | Formula: C18H17N3O4
  • H donors: 1 H acceptors: 4 LogP: 1.36 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccnc1)OCC(=O)N1c2ccccc2NC(=O)C1(C)C
  • InChi: 1S/C18H17N3O4/c1-18(2)17(24)20-13-7-3-4-8-14(13)21(18)15(22)11-25-16(23)12-6-5-9-19-10-12/h3-10H,11H2,1-2H3,(H,20,24)
  • InChiKey: DKMPAVPZCHYPBI-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • [2-(2,2-dimethyl-3-oxo-4H-quinoxalin-1-yl)-2-oxo-ethyl] pyridine-3-carboxylate
  • 3-pyridinecarboxylic acid [2-(2,2-dimethyl-3-oxo-4H-quinoxalin-1-yl)-2-oxoethyl] ester
  • nicotinic acid [2-keto-2-(3-keto-2,2-dimethyl-4H-quinoxalin-1-yl)ethyl] ester
  • T5589595
  • ZINC08262532

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans hypothetical protein 0.0023 0.0179 0.2498
Loa Loa (eye worm) hypothetical protein 0.0041 0.0445 0.0812
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0445 0.0445
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0037 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0931 0.0931
Echinococcus granulosus cpg binding protein 0.0067 0.083 0.083
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0199 0.0199
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.0617 0.0942
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0445 0.0445
Plasmodium vivax SET domain protein, putative 0.0032 0.0311 0.6226
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0945 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0602 0.0602
Toxoplasma gondii ABC1 family protein 0.0041 0.0445 0.2148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.0278
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0201 0.0201
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.3066 0.5898
Loa Loa (eye worm) hypothetical protein 0.0041 0.0445 0.0812
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0658 0.0658
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0179 0.0244
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0028 0.0246 0.0427
Onchocerca volvulus Cathepsin L homolog 0.002 0.0123 0.0278
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0199 0.0275
Brugia malayi Cathepsin L-like precursor 0.002 0.0123 0.0154
Loa Loa (eye worm) hypothetical protein 0.0052 0.0617 0.1147
Onchocerca volvulus 0.002 0.0123 0.0278
Echinococcus granulosus geminin 0.037 0.5376 0.5376
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.0617 0.0617
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0445 0.0667
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0945 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0617 0.1147
Loa Loa (eye worm) hypothetical protein 0.0052 0.0602 0.1118
Entamoeba histolytica hypothetical protein 0.0027 0.0236 0.0335
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0246 0.035
Entamoeba histolytica hypothetical protein 0.0432 0.6305 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.0278
Brugia malayi steroid hormone receptor 0.0052 0.0617 0.0942
Onchocerca volvulus 0.0061 0.0745 0.2064
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0443 0.0443
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0123 0.0278
Loa Loa (eye worm) hypothetical protein 0.0025 0.0201 0.034
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0658 0.0658
Schistosoma mansoni zinc finger protein 0.0017 0.0091 0.0091
Leishmania major hypothetical protein, conserved 0.0041 0.0445 0.4138
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0179 0.0244
Brugia malayi hypothetical protein 0.0028 0.0246 0.035
Loa Loa (eye worm) hypothetical protein 0.0025 0.0201 0.034
Loa Loa (eye worm) RNA binding protein 0.0073 0.0931 0.1756
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0126
Loa Loa (eye worm) hypothetical protein 0.0023 0.0179 0.0298
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0907 0.1404
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0037 0.0033
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0123 0.0154
Brugia malayi Pre-SET motif family protein 0.0032 0.0311 0.0454
Loa Loa (eye worm) hypothetical protein 0.0025 0.0201 0.034
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0199 0.4489
Schistosoma mansoni coup transcription factor 0.0052 0.0617 0.0617
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0173 0.2311
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0209 0.0579
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.0278
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0179 0.0244
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0445 1
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0331 0.0331
Brugia malayi tailless protein 0.0025 0.0201 0.0279
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.0707 0.7205
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0311 0.0311
Echinococcus multilocularis cpg binding protein 0.0067 0.083 0.083
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0658 0.1007
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0267 0.0267
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0179 0.2498
Schistosoma mansoni bromodomain containing protein 0.0076 0.0962 0.0962
Brugia malayi TAR-binding protein 0.0073 0.0931 0.1441
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0179 0.1032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0658 0.0658
Loa Loa (eye worm) histone methyltransferase 0.002 0.013 0.0202
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.0278
Brugia malayi nuclear hormone receptor 0.0052 0.0617 0.0942
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.0278
Schistosoma mansoni nuclear receptor nhr-48 0.0025 0.0201 0.0201
Brugia malayi nuclear receptor NHR-88 0.0052 0.0617 0.0942
Entamoeba histolytica hypothetical protein 0.0432 0.6305 1
Brugia malayi Bromodomain containing protein 0.0044 0.0484 0.0729
Echinococcus granulosus zinc finger protein 0.0026 0.0216 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0037 0.0033
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0182 0.0303
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0617 0.0617
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0931 0.1441
Schistosoma mansoni cpg binding protein 0.0067 0.083 0.083
Brugia malayi nuclear receptor RXR 0.0028 0.0246 0.035
Schistosoma mansoni cpg binding protein 0.0067 0.083 0.083
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0443 0.0443
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0159 0.0212
Onchocerca volvulus 0.002 0.0123 0.0278
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0617 0.0942
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0658 0.0658
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0123 0.0278
Echinococcus multilocularis dnaJ subfamily B 0.0421 0.615 0.615
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0445 1
Brugia malayi hypothetical protein 0.0432 0.6305 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0931 0.1756
Mycobacterium ulcerans hypothetical protein 0.0041 0.0445 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0945 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.0617 0.0942
Brugia malayi Cathepsin L-like precursor 0.002 0.0123 0.0154
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0262 0.3757 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0123 0.0188
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.0602 0.0602
Schistosoma mansoni hypothetical protein 0.0072 0.0907 0.0907
Schistosoma mansoni hypothetical protein 0.0432 0.6305 0.6305
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0033 0.0328 0.0587
Schistosoma mansoni nuclear receptor 0.0025 0.0201 0.0201
Echinococcus multilocularis thyroid hormone receptor alpha 0.0052 0.0617 0.0617
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0445 0.1202
Schistosoma mansoni microtubule-associated protein tau 0.0678 1 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0173 0.0334
Loa Loa (eye worm) hypothetical protein 0.0025 0.0201 0.034
Schistosoma mansoni hypothetical protein 0.0033 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0025 0.0201 0.034
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0445 0.1
Echinococcus multilocularis zinc finger protein 0.0026 0.0216 0.0216
Onchocerca volvulus 0.0052 0.0617 0.1697
Loa Loa (eye worm) DR-78 0.0025 0.0201 0.034
Schistosoma mansoni hypothetical protein 0.0033 0.0328 0.0328
Echinococcus multilocularis GPCR, family 2 0.0033 0.0328 0.0328
Entamoeba histolytica Ran family GTPase 0.0025 0.0199 0.0275
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0617 0.0617
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0617 0.0617
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.1406 0.2198
Leishmania major cathepsin L-like protease 0.002 0.0123 0.037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0123 0.0278
Brugia malayi nuclear receptor NHR-67 0.0025 0.0201 0.0279
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.0617 0.0617
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0209 0.1385
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0173 0.5
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0931 0.1756
Loa Loa (eye worm) hypothetical protein 0.0052 0.0617 0.1147
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0123 0.1322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0052 0.0617 0.1147
Brugia malayi RNA, U transporter 1 0.0095 0.1255 0.1957
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.0278
Loa Loa (eye worm) hypothetical protein 0.0052 0.0617 0.1147
Brugia malayi beta-lactamase family protein 0.0041 0.0445 0.0667
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0267 0.0267
Mycobacterium tuberculosis Conserved protein 0.0041 0.0445 0.1
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0123 0.0154
Brugia malayi Cathepsin L-like precursor 0.002 0.0123 0.0154
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0179 0.2498
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0311 0.0311
Brugia malayi Pre-SET motif family protein 0.0216 0.3066 0.4841
Echinococcus granulosus tar DNA binding protein 0.0073 0.0931 0.0931
Schistosoma mansoni hypothetical protein 0.0023 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0025 0.0201 0.034
Echinococcus multilocularis snurportin 1 0.0357 0.518 0.518
Onchocerca volvulus Bile acid receptor homolog 0.0052 0.0617 0.1697
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0037 0.0033
Mycobacterium leprae Probable lipase LipE 0.0041 0.0445 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0173 1
Mycobacterium tuberculosis Conserved protein 0.0041 0.0445 0.1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0037 0.0033
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0179 0.0243
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0201 0.0279
Echinococcus granulosus nuclear receptor nhr 48 0.0025 0.0201 0.0201
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0173 0.0955
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0037 0.0033
Echinococcus multilocularis nuclear receptor nhr 48 0.0025 0.0201 0.0201
Echinococcus multilocularis geminin 0.037 0.5376 0.5376
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0209 0.335
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0901 0.0901
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0945 1
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0931 0.0931
Loa Loa (eye worm) hypothetical protein 0.0023 0.0179 0.0298
Echinococcus multilocularis microtubule associated protein 2 0.0678 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0658 0.1227
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0445 1
Loa Loa (eye worm) cysteine protease 0.002 0.0123 0.0188
Trichomonas vaginalis ran, putative 0.0025 0.0199 0.0496
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0123 0.0123
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0037 0.0033
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0173 0.0955
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0037 0.0033
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0123 0.0123
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0123 0.0278
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0945 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0052 0.0617 0.1147
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0037 0.0033
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.0617 0.0617
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0074 0.0074
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0236 0.1699
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0901 0.0901
Echinococcus granulosus cathepsin l1 0.002 0.0123 0.0123
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.0617 0.0617
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.0278
Loa Loa (eye worm) hypothetical protein 0.0028 0.0246 0.0427
Brugia malayi CXXC zinc finger family protein 0.0061 0.0745 0.1145
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0617 0.0617
Brugia malayi beta-lactamase family protein 0.0041 0.0445 0.0667
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.0617 0.0617
Loa Loa (eye worm) hypothetical protein 0.0041 0.0445 0.0812
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.0278
Brugia malayi ecdysone receptor 0.0025 0.0201 0.0279
Onchocerca volvulus 0.0041 0.0445 0.1202
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0236 0.0604
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0445 0.1202
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.013 0.013
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0179 0.0244
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0432 0.6305 0.6305
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0931 0.0931
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0199 0.0199
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0179 0.2498
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0091 0.0039
Loa Loa (eye worm) hypothetical protein 0.0052 0.061 0.1134
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0123 0.0123
Brugia malayi ecdysteroid receptor 0.0052 0.0617 0.0942
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0328 0.0482
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0931 0.0931
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0179 0.0243
Loa Loa (eye worm) hypothetical protein 0.0081 0.1049 0.1984
Schistosoma mansoni hypothetical protein 0.037 0.5376 0.5376
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.0617 0.0942
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0123 0.1322
Loa Loa (eye worm) hypothetical protein 0.0052 0.0617 0.1147
Schistosoma mansoni hypothetical protein 0.037 0.5376 0.5376
Echinococcus granulosus dnaJ subfamily B 0.0421 0.615 0.615
Loa Loa (eye worm) hypothetical protein 0.0041 0.0445 0.0812
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0201 0.0201
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0123 0.037
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0201 0.0201
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0037 0.0033
Brugia malayi PHD-finger family protein 0.0032 0.0307 0.0448
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0274 0.0274
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0201 0.0201
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0199 0.0335
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0331 0.139
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0745 0.1395
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0173 0.0334
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0331 0.2808
Brugia malayi nuclear hormone receptor 0.0025 0.0201 0.0279
Loa Loa (eye worm) hypothetical protein 0.0025 0.0201 0.034
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0199 0.126
Brugia malayi nuclear hormone receptor family member odr-7 0.0025 0.0201 0.0279
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0121 0.0121
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.1049 0.1629
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.0617 0.0617
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0209 0.4935
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0179 0.2498
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0199 0.3047
Brugia malayi Cathepsin L-like precursor 0.002 0.0123 0.0154
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0121 0.0121
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0445 0.1202
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0445 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.1049 0.1049
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0179 0.0279
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0328 0.0328
Onchocerca volvulus 0.002 0.0123 0.0278
Loa Loa (eye worm) beta-lactamase 0.0041 0.0445 0.0812
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0945 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0037 0.0033
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0445 0.0812
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0617 0.0617
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0617 0.0942
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0025 0.0201 0.034
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0199 0.126
Loa Loa (eye worm) fibroinase 0.002 0.0123 0.0188
Leishmania major GTP-binding protein, putative 0.0025 0.0199 0.126
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0931 0.0931
Trichomonas vaginalis helicase, putative 0.0014 0.0037 0.0033
Schistosoma mansoni cpg binding protein 0.0061 0.0745 0.0745
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0074 0.0074
Leishmania major cathepsin L-like protease 0.0074 0.0945 1
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0123 0.0123
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0432 0.6305 0.6305
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0328 0.0482
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0179 0.2498
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0123 0.0278
Leishmania major cathepsin L-like protease 0.0074 0.0945 1
Schistosoma mansoni zinc finger protein 0.0025 0.0201 0.0201
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0201 0.0503
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0037 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0037 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.0617 0.0942
Loa Loa (eye worm) hypothetical protein 0.0028 0.0246 0.0427
Leishmania major hypothetical protein, conserved 0.0025 0.0209 0.1385
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0179 0.0244
Brugia malayi Steroid receptor seven-up type 2 0.0052 0.0617 0.0942
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0074 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.0617 0.0942
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0328 0.0587
Onchocerca volvulus 0.0025 0.0201 0.0503
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0445 0.0445
Schistosoma mansoni ran 0.0025 0.0199 0.0199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0945 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0123 0.0154
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0123 0.0278
Schistosoma mansoni hypothetical protein 0.0017 0.0091 0.0091
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0357 0.518 1
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0131 0.0205
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0026 0.0026
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0179 0.2498
Leishmania major cathepsin L-like protease 0.002 0.0123 0.037
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0025 0.0201 0.0201
Loa Loa (eye worm) steroid hormone receptor 0.0052 0.0617 0.1147
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0123 0.0278
Brugia malayi Importin beta-1 subunit 0.0033 0.0331 0.0486
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0123 0.0278
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.1049 0.1049
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0331 0.2808
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0602 0.0602
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0209 0.1385
Brugia malayi Bromodomain containing protein 0.0089 0.1163 0.181
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0173 0.2311
Plasmodium vivax vivapain-2 0.002 0.0123 0.0897
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.0617 0.0942
Onchocerca volvulus 0.0032 0.0311 0.0819
Leishmania major cathepsin L-like protease 0.002 0.0123 0.037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.0278
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.0617 0.0942
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0052 0.0617 0.1147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0052 0.0617 0.1147
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0121 0.0121
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0037 0.0033
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0179 0.1032
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.1406 0.2198
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0236 0.0604
Onchocerca volvulus 0.002 0.0123 0.0278
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0945 1
Entamoeba histolytica hypothetical protein 0.0432 0.6305 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0037 0.0033
Onchocerca volvulus 0.0023 0.0179 0.044
Brugia malayi hypothetical protein 0.0016 0.0075 0.0078
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0123 0.0123
Onchocerca volvulus 0.002 0.0123 0.0278
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0931 0.0931
Loa Loa (eye worm) hypothetical protein 0.0046 0.0525 0.0969
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0201 0.0201
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.0617 0.0617
Mycobacterium ulcerans lipase LipD 0.0041 0.0445 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0052 0.0617 0.1147
Loa Loa (eye worm) hypothetical protein 0.0044 0.0485 0.0891
Loa Loa (eye worm) hypothetical protein 0.0028 0.0246 0.0427
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0025 0.0201 0.0201
Toxoplasma gondii histone lysine methyltransferase SET1 0.0119 0.1621 1
Brugia malayi hypothetical protein 0.0025 0.0201 0.0279
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.0602 0.0602
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.0617 0.0617
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.1049 0.1049
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0052 0.0617 0.0617
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.1406 0.2678
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0052 0.0617 0.1147
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0328 0.0328
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0201 0.0201
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.0849 0.8867
Brugia malayi hypothetical protein 0.0028 0.0246 0.035
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0201 0.0503
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0617 0.0942
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0311 0.0311
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.0617 0.0617
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0658 0.0658
Loa Loa (eye worm) hypothetical protein 0.0025 0.0201 0.034
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0123 0.0154
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0236 0.0604
Leishmania major cathepsin L-like protease 0.002 0.0123 0.037
Brugia malayi conserved hypotetical protein 0.0025 0.0201 0.0279
Loa Loa (eye worm) hypothetical protein 0.0025 0.0201 0.034
Loa Loa (eye worm) hypothetical protein 0.0023 0.0179 0.0298
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0445 0.0445
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0052 0.0617 0.1697
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0445 0.1202
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0445 0.1
Leishmania major cysteine peptidase A (CPA) 0.002 0.0123 0.037
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0179 0.1032
Onchocerca volvulus 0.0041 0.0445 0.1202
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0131 0.1788 0.1788
Schistosoma mansoni hypothetical protein 0.0033 0.0328 0.0328
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0201 0.0201
Schistosoma mansoni hypothetical protein 0.0357 0.518 0.518
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0052 0.0617 0.0617
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.0617 0.0617
Onchocerca volvulus 0.002 0.0123 0.0278
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0123 0.0278
Onchocerca volvulus 0.002 0.0123 0.0278
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0445 0.4138
Leishmania major importin beta-1 subunit, putative 0.0027 0.0236 0.1699
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.0278
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.0617 0.0617
Entamoeba histolytica hypothetical protein 0.0023 0.0173 0.0234
Onchocerca volvulus Cathepsin F homolog 0.002 0.0123 0.0278
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0179 0.0279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.0278
Onchocerca volvulus 0.0041 0.0445 0.1202
Echinococcus granulosus snurportin 1 0.0357 0.518 0.518
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0037 0.0033
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0201 0.0201
Brugia malayi RNA binding protein 0.0073 0.0931 0.1441
Plasmodium vivax importin-beta 2, putative 0.0033 0.0331 0.6788
Onchocerca volvulus Cathepsin L homolog 0.002 0.0123 0.0278
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0123 0.1322
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.0617 0.0617
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0037 0.0033
Loa Loa (eye worm) hypothetical protein 0.0025 0.0201 0.034
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0025 0.0201 0.0279
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0126
Entamoeba histolytica cysteine protease, putative 0.002 0.0123 0.0154
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0445 0.4138
Onchocerca volvulus 0.0081 0.1049 0.2936
Plasmodium vivax vivapain-2 0.002 0.0123 0.0897
Brugia malayi nuclear hormone receptor family member nhr-6 0.0025 0.0201 0.0279
Loa Loa (eye worm) hypothetical protein 0.0025 0.0209 0.0356
Brugia malayi Cathepsin L-like precursor 0.002 0.0123 0.0154
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0025 0.0201 0.034
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0617 0.0617
Schistosoma mansoni hypothetical protein 0.0421 0.615 0.615
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.0278
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.0617 0.0617
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0617 0.0942
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0311 0.1257
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0246 0.0246
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.0199 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.0445 0.0812
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0209 0.1385
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0173 0.2311
Echinococcus granulosus importin subunit beta 1 0.0033 0.0331 0.0331
Trichomonas vaginalis set domain proteins, putative 0.0245 0.351 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0033 0.0331 0.0592
Loa Loa (eye worm) hypothetical protein 0.0025 0.0201 0.034
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0179 0.0244
Mycobacterium ulcerans beta-lactamase 0.0041 0.0445 1
Trichomonas vaginalis esterase, putative 0.0041 0.0445 0.1202
Onchocerca volvulus Protein ultraspiracle homolog 0.0052 0.0617 0.1697
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0123 0.0278
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0445 0.4138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0945 1
Loa Loa (eye worm) ctsf protein 0.002 0.0123 0.0188
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0199 0.126
Echinococcus granulosus cathepsin l1 0.0013 0.0026 0.0026
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0074 0.0074
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0123 0.0188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0945 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.0278
Echinococcus multilocularis cysteine protease 0.002 0.0123 0.0123
Plasmodium falciparum importin beta, putative 0.0033 0.0331 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.013 0.013
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0025 0.0201 0.0201
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0173 0.3404
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.0617 0.0617
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0199 0.0507
Loa Loa (eye worm) hypothetical protein 0.0052 0.0617 0.1147
Loa Loa (eye worm) nuclear hormone receptor 0.0025 0.0201 0.034
Mycobacterium tuberculosis Conserved protein 0.0041 0.0445 0.1
Leishmania major cathepsin L-like protease 0.002 0.0123 0.037
Echinococcus granulosus FTZ F1 alpha 0.0052 0.0617 0.0617
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0658 0.0658
Schistosoma mansoni transcription factor LCR-F1 0.0432 0.6305 0.6305
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0025 0.0201 0.0201
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0617 0.0942
Loa Loa (eye worm) hypothetical protein 0.0052 0.0617 0.1147
Schistosoma mansoni ran 0.0025 0.0199 0.0199
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0025 0.0201 0.034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.0278
Loa Loa (eye worm) hypothetical protein 0.0028 0.0246 0.0427
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0246 0.035
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0945 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0658 0.0658
Loa Loa (eye worm) hypothetical protein 0.0072 0.0907 0.171
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0445 0.1
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0945 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0209 0.4935
Schistosoma mansoni hypothetical protein 0.0033 0.0328 0.0328
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0445 0.1
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0201 0.0279
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0945 1
Brugia malayi nuclear receptor NHR-88 0.0025 0.0201 0.0279
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0028 0.0246 0.0246
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0028 0.0246 0.0246
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0945 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0267 0.0267
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0123 0.0278
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.0617 0.0617
Entamoeba histolytica hypothetical protein 0.0432 0.6305 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0445 0.1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.0617 0.0942
Loa Loa (eye worm) hypothetical protein 0.0081 0.1037 0.1963
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0126
Brugia malayi hypothetical protein 0.0025 0.0201 0.0279
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0179 0.2498
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0445 0.1202
Brugia malayi beta-lactamase 0.0041 0.0445 0.0667
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0445 0.1
Loa Loa (eye worm) hypothetical protein 0.0105 0.1406 0.2678
Schistosoma mansoni nuclear receptor 0.0025 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.002 0.0123 0.0188
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0617 0.0942
Loa Loa (eye worm) hypothetical protein 0.0028 0.0246 0.0427
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0617 0.0942
Onchocerca volvulus 0.0025 0.0201 0.0503
Loa Loa (eye worm) hypothetical protein 0.0041 0.0445 0.0812
Leishmania major cathepsin L-like protease 0.0074 0.0945 1
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0445 0.1
Onchocerca volvulus 0.0245 0.351 1
Echinococcus multilocularis cysteine protease 0.002 0.0123 0.0123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0052 0.0617 0.1147
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0025 0.0201 0.0201
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.0617 0.0617
Echinococcus granulosus GPCR family 2 0.0033 0.0328 0.0328
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0945 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0328 0.0328
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0173 0.5
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0617 0.0617
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0028 0.0246 0.0246
Brugia malayi nuclear receptor RXR 0.0025 0.0201 0.0279
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.0617 0.0617
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0617 0.0617
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0123 0.0123
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.0617 0.0617
Loa Loa (eye worm) nuclear receptor NHR-67 0.0025 0.0201 0.034
Brugia malayi hypothetical protein 0.0025 0.0209 0.0292
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0173 0.0261
Schistosoma mansoni importin beta-1 0.0033 0.0331 0.0331
Echinococcus granulosus thyroid hormone receptor alpha 0.0025 0.0201 0.0201
Brugia malayi orphan nuclear receptor NR2E1 0.0025 0.0201 0.0279
Loa Loa (eye worm) hypothetical protein 0.0052 0.0617 0.1147
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0328 0.0328
Schistosoma mansoni zinc finger protein 0.0026 0.0216 0.0216

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8275 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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