Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.1983 | 0.6053 |
Brugia malayi | MAP kinase sur-1 | 0.0052 | 0.3275 | 0.3275 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.1983 | 0.6053 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.1983 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2789 | 0.8515 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.3275 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.2789 | 0.8515 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0052 | 0.3275 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0322 | 0.0984 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.162 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.3193 | 0.3193 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.1983 | 0.5622 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0034 | 0.162 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.3193 | 0.3193 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.1983 | 0.1983 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1715 | 0.5236 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.2789 | 0.2789 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0052 | 0.3275 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.1983 | 0.6053 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0322 | 0.0322 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0322 | 0.0322 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0052 | 0.3275 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0052 | 0.3275 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.3193 | 0.3193 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 1 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.1983 | 0.6053 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0038 | 0.1983 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.002 | 0.0322 | 0.0984 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.2789 | 0.8515 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.0322 | 0.0322 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0052 | 0.3275 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0052 | 0.3275 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0052 | 0.3275 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.3193 | 0.3193 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.2789 | 0.8515 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.1715 | 0.1715 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 1 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1983 | 0.5622 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1983 | 0.5622 |
Echinococcus granulosus | dna polymerase eta | 0.002 | 0.0322 | 0.0984 |
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.0322 | 0.0984 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0052 | 0.3275 | 1 |
Brugia malayi | Inositol-1 | 0.0038 | 0.1983 | 0.1983 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.1983 | 0.5622 |
Schistosoma mansoni | DNA polymerase eta | 0.002 | 0.0322 | 0.0984 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.2789 | 0.8515 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0052 | 0.3275 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0127 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0052 | 0.3275 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.1983 | 0.5622 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1983 | 0.5622 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.2789 | 0.2789 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.0322 | 0.0984 |
Trypanosoma brucei | protein kinase, putative | 0.0052 | 0.3275 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0052 | 0.3275 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.0322 | 0.0984 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0052 | 0.3275 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0322 | 0.0984 |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.0322 | 0.0984 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.3275 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1983 | 0.5622 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0322 | 0.0322 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.1983 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2789 | 0.8515 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.3275 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.3275 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.3275 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0127 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0052 | 0.3275 | 0.3275 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1715 | 0.1715 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0052 | 0.3275 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2789 | 0.8515 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 20.5878 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.