Detailed information for compound 1533225

Basic information

Technical information
  • TDR Targets ID: 1533225
  • Name: ethyl 2-[[4-chloro-6-[(4-chlorophenyl)amino]- 1,3,5-triazin-2-yl]amino]-4-methylsulfanylbut anoate
  • MW: 416.325 | Formula: C16H19Cl2N5O2S
  • H donors: 2 H acceptors: 4 LogP: 5.08 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSCCC(C(=O)OCC)Nc1nc(Nc2ccc(cc2)Cl)nc(n1)Cl
  • InChi: 1S/C16H19Cl2N5O2S/c1-3-25-13(24)12(8-9-26-2)20-16-22-14(18)21-15(23-16)19-11-6-4-10(17)5-7-11/h4-7,12H,3,8-9H2,1-2H3,(H2,19,20,21,22,23)
  • InChiKey: QJDAZWYWZZCXHN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-[[4-chloro-6-[(4-chlorophenyl)amino]-1,3,5-triazin-2-yl]amino]-4-methylsulfanyl-butanoate
  • 2-[[4-chloro-6-[(4-chlorophenyl)amino]-1,3,5-triazin-2-yl]amino]-4-(methylthio)butanoic acid ethyl ester
  • 2-[[4-chloro-6-[(4-chlorophenyl)amino]-s-triazin-2-yl]amino]-4-(methylthio)butyric acid ethyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans glutamate synthase subunit beta 0.0024 0.0209 0.1212
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0679 0.0722
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0089 0.0963 0.5823
Trichomonas vaginalis set domain proteins, putative 0.0256 0.2884 0.8392
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0301 0.032
Trypanosoma cruzi NADH dehydrogenase, putative 0.0024 0.0209 0.0686
Echinococcus granulosus dna polymerase kappa 0.0021 0.0177 0.0264
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0586 0.669 0.811
Brugia malayi conserved hypotetical protein 0.0015 0.0109 0.0181
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0109 0.0073
Echinococcus multilocularis dnaJ subfamily B 0.0424 0.4825 0.4806
Echinococcus multilocularis smad 0.001 0.005 0.0014
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0109 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0102 0.0315
Brugia malayi RNA binding protein 0.0197 0.2208 0.4105
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0024 0.0209 0.0174
Schistosoma mansoni zinc finger protein 0.0015 0.0109 0.0115
Echinococcus multilocularis glutamate synthase 0.0024 0.0209 0.0174
Schistosoma mansoni smad1 5 8 and 0.001 0.005 0.0053
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0177 0.0572
Loa Loa (eye worm) hypothetical protein 0.0112 0.1232 0.228
Loa Loa (eye worm) hypothetical protein 0.0032 0.0301 0.054
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0484 0.0884
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0177 0.0473
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0089 0.0963 0.3297
Loa Loa (eye worm) hypothetical protein 0.0471 0.5363 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0109 0.0181
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.1232 0.4228
Loa Loa (eye worm) hypothetical protein 0.0033 0.0315 0.0567
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0177 0.0572
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0301 0.054
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0102 0.0315
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0177 0.0264
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.0963 0.3297
Brugia malayi tailless protein 0.0015 0.0109 0.0181
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0301 0.032
Loa Loa (eye worm) glutathione reductase 0.0257 0.2897 0.5393
Mycobacterium tuberculosis Probable esterase LipL 0.0112 0.1232 0.1314
Schistosoma mansoni cpg binding protein 0.0031 0.03 0.0319
Schistosoma mansoni sulfide quinone reductase 0.0024 0.0209 0.0223
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0024 0.0209 0.0041
Onchocerca volvulus 0.0032 0.0301 0.0692
Brugia malayi Pre-SET motif family protein 0.0225 0.2527 0.4701
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0024 0.0209 0.0326
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.3434 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0209 0.0569
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0484 0.0515
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0024 0.0209 0.0686
Mycobacterium tuberculosis Probable reductase 0.0586 0.669 0.811
Loa Loa (eye worm) beta-lactamase 0.0112 0.1232 0.228
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0315 0.028
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0129 0.022
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0301 0.0265
Schistosoma mansoni tar DNA-binding protein 0.0197 0.2208 0.2349
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0177 0.0141
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0089 0.0963 0.5823
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0057 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0177 0.0572
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0301 0.054
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0024 0.0209 0.0686
Loa Loa (eye worm) hypothetical protein 0.0112 0.1232 0.228
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0177 0.0572
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0024 0.0209 0.0686
Trichomonas vaginalis esterase, putative 0.0112 0.1232 0.3559
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0301 0.054
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0652 0.7443 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0301 0.054
Brugia malayi hypothetical protein 0.0017 0.0129 0.022
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0129 0.022
Brugia malayi TAR-binding protein 0.0197 0.2208 0.4105
Trypanosoma cruzi trypanothione reductase, putative 0.0257 0.2897 1
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0177 0.0309
Onchocerca volvulus 0.003 0.028 0.0619
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.1232 0.131
Mycobacterium leprae Probable lipase LipE 0.0112 0.1232 0.1413
Schistosoma mansoni Smad4 0.001 0.005 0.0053
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0294 0.0484
Schistosoma mansoni cpg binding protein 0.0031 0.03 0.0319
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0109 0.0073
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0011 0.0012
Onchocerca volvulus 0.0256 0.2884 1
Trypanosoma brucei NADH dehydrogenase 0.0024 0.0209 0.0686
Brugia malayi hypothetical protein 0.0015 0.0109 0.0181
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0177 0.0188
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0024 0.0209 0.1212
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.3434 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0089 0.0963 0.3297
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0177 0.0572
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0024 0.0209 0.0101
Brugia malayi glutamate synthase 0.0024 0.0209 0.037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0484 0.0515
Loa Loa (eye worm) hypothetical protein 0.0015 0.0109 0.0181
Brugia malayi MH1 domain containing protein 0.001 0.005 0.0072
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0109 0.0181
Echinococcus granulosus tar DNA binding protein 0.0197 0.2208 0.4077
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0209 0.0686
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0301 0.054
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0177 0.0572
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0024 0.0209 0.0569
Brugia malayi nuclear receptor RXR 0.0015 0.0109 0.0181
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0601 0.2043
Brugia malayi MH2 domain containing protein 0.001 0.005 0.0072
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0112 0.1232 0.7468
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.0963 0.3297
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0177 0.0572
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0315 0.1052
Trypanosoma brucei unspecified product 0.0014 0.0102 0.0315
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0301 0.032
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0301 0.032
Brugia malayi nuclear receptor NHR-88 0.0015 0.0109 0.0181
Leishmania major hypothetical protein, conserved 0.0112 0.1232 0.4228
Brugia malayi MH1 domain containing protein 0.001 0.005 0.0072
Mycobacterium leprae conserved hypothetical protein 0.0112 0.1232 0.1413
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0024 0.0209 0.0686
Brugia malayi hypothetical protein 0.0017 0.0129 0.022
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0089 0.0963 0.5823
Loa Loa (eye worm) hypothetical protein 0.0032 0.0301 0.054
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0177 0.0572
Loa Loa (eye worm) Smad1 0.001 0.005 0.0072
Echinococcus multilocularis thioredoxin glutathione reductase 0.0259 0.2922 0.2896
Mycobacterium ulcerans esterase/lipase LipP 0.0112 0.1232 0.7468
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0024 0.0209 0.0174
Schistosoma mansoni smad1 5 8 and 0.001 0.005 0.0053
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0024 0.0209 0.0686
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0257 0.2897 0.3388
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0301 0.054
Trichomonas vaginalis mercuric reductase, putative 0.0089 0.0963 0.2773
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0301 0.054
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.2527 0.4701
Giardia lamblia NADH oxidase lateral transfer candidate 0.0089 0.0963 0.278
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0301 0.0496
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0586 0.669 0.811
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.1232 0.3559
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0301 0.054
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0177 0.0473
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0024 0.0209 0.0686
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0301 0.032
Leishmania major hypothetical protein, conserved 0.0024 0.0209 0.0686
Brugia malayi Muscleblind-like protein 0.0471 0.5363 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0109 0.0181
Mycobacterium tuberculosis Probable dehydrogenase 0.0586 0.669 0.811
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.3434 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0112 0.1232 0.2244
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0301 0.032
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0065 0.0691 0.1269
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0177 0.0572
Brugia malayi ecdysone receptor 0.0015 0.0109 0.0181
Loa Loa (eye worm) hypothetical protein 0.0017 0.0129 0.022
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0301 0.054
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0089 0.0963 0.093
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.3434 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.005 0.0053
Echinococcus granulosus cpg binding protein 0.0031 0.03 0.0495
Loa Loa (eye worm) hypothetical protein 0.0015 0.0109 0.0181
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0065 0.0691 0.1269
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0089 0.0963 0.3297
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0109 0.0073
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0024 0.0209 0.1212
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0109 0.0181
Schistosoma mansoni nuclear receptor 0.0015 0.0109 0.0115
Schistosoma mansoni glutamate synthase 0.0024 0.0209 0.0223
Loa Loa (eye worm) hypothetical protein 0.0112 0.1232 0.228
Onchocerca volvulus 0.0112 0.1232 0.4046
Loa Loa (eye worm) hypothetical protein 0.0112 0.1232 0.228
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.0963 0.3297
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0089 0.0963 0.174
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.3434 1
Mycobacterium ulcerans ferredoxin reductase 0.0024 0.0209 0.1212
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0024 0.0209 0.0686
Loa Loa (eye worm) hypothetical protein 0.0112 0.1232 0.228
Schistosoma mansoni tar DNA-binding protein 0.0197 0.2208 0.2349
Onchocerca volvulus 0.0024 0.0209 0.0363
Mycobacterium ulcerans lipase LipD 0.0112 0.1232 0.7468
Plasmodium falciparum glutathione reductase 0.0089 0.0963 0.3297
Giardia lamblia Thioredoxin reductase 0.0024 0.0209 0.0578
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0024 0.0209 0.0686
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0024 0.0209 0.0174
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1232 0.3559
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0024 0.0209 0.0686
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0301 0.054
Brugia malayi nuclear receptor RXR 0.0017 0.0129 0.022
Mycobacterium tuberculosis Probable lipase LipE 0.0112 0.1232 0.1314
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0301 0.054
Treponema pallidum fructose-bisphosphate aldolase 0.0304 0.3434 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0089 0.0963 0.3297
Plasmodium vivax glutathione reductase, putative 0.0257 0.2897 1
Plasmodium falciparum thioredoxin reductase 0.0089 0.0963 0.3297
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0484 0.0884
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0652 0.7443 0.9049
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.005 0.0027
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0024 0.0209 0.0686
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0484 0.0515
Echinococcus granulosus smad 0.001 0.005 0.0027
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0024 0.0209 0.0686
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.1645 0.1829
Trypanosoma brucei unspecified product 0.0014 0.0102 0.0315
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0315 0.0335
Loa Loa (eye worm) hypothetical protein 0.0015 0.0109 0.0181
Loa Loa (eye worm) hypothetical protein 0.0112 0.1232 0.228
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0177 0.0572
Schistosoma mansoni nuclear receptor 0.0015 0.0109 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0177 0.0572
Brugia malayi Pre-SET motif family protein 0.0033 0.0315 0.0567
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0484 0.0842
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0315 0.0335
Trichomonas vaginalis glutamate synthase, putative 0.0024 0.0209 0.0569
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0301 0.0496
Onchocerca volvulus 0.0033 0.0315 0.0744
Echinococcus granulosus thioredoxin glutathione reductase 0.0259 0.2922 0.5417
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0109 0.0181
Mycobacterium tuberculosis Probable lipase LipD 0.0112 0.1232 0.1314
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.3434 1
Echinococcus multilocularis cpg binding protein 0.0031 0.03 0.0265
Echinococcus multilocularis dna polymerase eta 0.0021 0.0177 0.0141
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0315 0.028
Loa Loa (eye worm) hypothetical protein 0.0015 0.0109 0.0181
Loa Loa (eye worm) DR-78 0.0015 0.0109 0.0181
Plasmodium vivax SET domain protein, putative 0.0033 0.0315 0.1052
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0109 0.0136
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.028 0.0502
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0301 0.0265
Brugia malayi MH2 domain containing protein 0.001 0.005 0.0072
Leishmania major hypothetical protein, conserved 0.0024 0.0209 0.0686
Brugia malayi beta-lactamase family protein 0.0112 0.1232 0.228
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0177 0.0309
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0024 0.0209 0.0101
Echinococcus multilocularis tar DNA binding protein 0.0197 0.2208 0.218
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0024 0.0209 0.1212
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0089 0.0963 0.0979
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0057 0.0021
Mycobacterium ulcerans dehydrogenase 0.0024 0.0209 0.1212
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0484 0.045
Brugia malayi nuclear receptor NHR-67 0.0015 0.0109 0.0181
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0109 0.0115
Loa Loa (eye worm) hypothetical protein 0.0015 0.0109 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0301 0.054
Mycobacterium tuberculosis Conserved protein 0.0112 0.1232 0.1314
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0024 0.0209 0.0686
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0024 0.0209 0.1212
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0301 0.054
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0301 0.032
Echinococcus granulosus dnaJ subfamily B 0.0424 0.4825 0.899
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0301 0.0496
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0024 0.0209 0.0569
Leishmania major DNA polymerase eta, putative 0.0021 0.0177 0.0572
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0177 0.0572
Loa Loa (eye worm) hypothetical protein 0.0015 0.0109 0.0181
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0109 0.0181
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0109 0.0073
Loa Loa (eye worm) hypothetical protein 0.0015 0.0109 0.0181
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0304 0.3434 1
Trichomonas vaginalis glutathione reductase, putative 0.0089 0.0963 0.2773
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0056 0.0082
Onchocerca volvulus 0.0112 0.1232 0.4046
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.1232 0.4228
Loa Loa (eye worm) hypothetical protein 0.0032 0.0301 0.054
Schistosoma mansoni sulfide quinone reductase 0.0024 0.0209 0.0223
Schistosoma mansoni hypothetical protein 0.0424 0.4825 0.5132
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0177 0.0572
Schistosoma mansoni glutamate synthase 0.0024 0.0209 0.0223
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0301 0.032
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0718 0.8207 1
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0301 0.0692
Echinococcus multilocularis beta LACTamase domain containing family member 0.0112 0.1232 0.12
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0024 0.0209 0.037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0301 0.054
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0109 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0301 0.054
Mycobacterium ulcerans hypothetical protein 0.0024 0.0209 0.1212
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0089 0.0963 0.1778
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0102 0.0315
Toxoplasma gondii NADPH-glutathione reductase 0.0089 0.0963 0.3297
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0024 0.0209 0.0569
Loa Loa (eye worm) hypothetical protein 0.0015 0.0109 0.0181
Loa Loa (eye worm) hypothetical protein 0.0032 0.0301 0.054
Trypanosoma brucei hypothetical protein, conserved 0.0112 0.1232 0.4228
Plasmodium falciparum ferrodoxin reductase-like protein 0.0024 0.0209 0.0686
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0109 0.0181
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0301 0.032
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0112 0.1232 0.228
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0652 0.7443 0.9049
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0197 0.2208 0.4105
Loa Loa (eye worm) hypothetical protein 0.0032 0.0301 0.054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0129 0.022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0129 0.022
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0177 0.0572
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0024 0.0209 0.0041
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0109 0.0181
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0109 0.0181
Entamoeba histolytica disulphide oxidoreductase, putative 0.0024 0.0209 0.0101
Brugia malayi beta-lactamase family protein 0.0112 0.1232 0.228
Echinococcus granulosus glutamate synthase 0.0024 0.0209 0.0326
Mycobacterium ulcerans monoxygenase 0.0024 0.0209 0.1212
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0024 0.0209 0.0101
Echinococcus multilocularis muscleblind protein 1 0.0471 0.5363 0.5346
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0301 0.054
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0089 0.0963 0.3297
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0301 0.032
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.005 0.0027
Schistosoma mansoni coup transcription factor 0.0032 0.0301 0.032
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.1645 1
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0177 0.1011
Echinococcus granulosus dna polymerase eta 0.0021 0.0177 0.0264
Toxoplasma gondii thioredoxin reductase 0.0257 0.2897 1
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0024 0.0209 0.037
Brugia malayi nuclear hormone receptor 0.0032 0.0301 0.054
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0177 0.0572
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0024 0.0209 0.037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0301 0.0265
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0177 0.0572
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0089 0.0963 0.3297
Giardia lamblia Glutamate synthase 0.0024 0.0209 0.0578
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0301 0.054
Brugia malayi Smad1 0.001 0.005 0.0072
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.3434 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0177 0.0572
Brugia malayi ecdysteroid receptor 0.0032 0.0301 0.054
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0024 0.0209 0.0686
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0177 0.0141
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0024 0.0209 0.0686
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0024 0.0209 0.0174
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0024 0.0209 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0177 0.0572
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0209 0.0686
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1597 0.2964
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0109 0.0136
Plasmodium vivax thioredoxin reductase, putative 0.0257 0.2897 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0089 0.0963 0.3297
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0129 0.022
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0301 0.032
Echinococcus multilocularis muscleblind protein 0.0471 0.5363 0.5346
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0112 0.1232 0.1314
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0209 0.0569
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0089 0.0963 0.3297
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0109 0.0136
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0109 0.0115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.3434 1
Loa Loa (eye worm) thioredoxin reductase 0.0257 0.2897 0.5393
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0586 0.669 0.8958
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0024 0.0209 0.0578
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0209 0.0569
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0177 0.0188
Loa Loa (eye worm) hypothetical protein 0.0021 0.0177 0.0309
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0301 0.0265
Brugia malayi steroid hormone receptor 0.0032 0.0301 0.054
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0024 0.0209 0.0101
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0024 0.0209 0.0101
Plasmodium falciparum thioredoxin reductase 0.0257 0.2897 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.1645 0.1985
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0301 0.0265
Brugia malayi beta-lactamase 0.0112 0.1232 0.228
Mycobacterium tuberculosis Conserved protein 0.0112 0.1232 0.1314
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0024 0.0209 0.1212
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0301 0.0496
Trypanosoma cruzi trypanothione reductase, putative 0.0089 0.0963 0.3297
Loa Loa (eye worm) hypothetical protein 0.0024 0.0209 0.037
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0109 0.0073
Loa Loa (eye worm) hypothetical protein 0.0017 0.0129 0.022
Leishmania major hypothetical protein, conserved 0.0024 0.0209 0.0686
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0315 0.0524
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0109 0.0115
Brugia malayi nuclear hormone receptor 0.0015 0.0109 0.0181
Schistosoma mansoni hypothetical protein 0.0024 0.0209 0.0223
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.005 0.0072
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0301 0.0496
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0209 0.0686
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0089 0.0963 0.3297
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.0963 0.3297
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0024 0.0209 0.0041
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0586 0.669 0.811
Plasmodium vivax hypothetical protein, conserved 0.0112 0.1232 0.4228
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0024 0.0209 0.0326
Onchocerca volvulus 0.0112 0.1232 0.4046
Trichomonas vaginalis glutamate synthase, putative 0.0024 0.0209 0.0569
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0129 0.0175
Loa Loa (eye worm) hypothetical protein 0.0017 0.0129 0.022
Loa Loa (eye worm) hypothetical protein 0.0032 0.0301 0.054
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1232 0.3559
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0301 0.0692
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0112 0.1232 0.1314
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0024 0.0209 0.0686
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0089 0.0963 0.3297
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0177 0.1011
Mycobacterium ulcerans beta-lactamase 0.0112 0.1232 0.7468
Brugia malayi nuclear receptor NHR-88 0.0032 0.0301 0.054
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0089 0.0963 0.3297
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0129 0.0137
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0315 0.0335
Loa Loa (eye worm) RNA binding protein 0.0197 0.2208 0.4105
Loa Loa (eye worm) TAR-binding protein 0.0197 0.2208 0.4105
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.005 0.0014
Brugia malayi hypothetical protein 0.0015 0.0109 0.0181
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0109 0.0115
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0024 0.0209 0.1212
Toxoplasma gondii ABC1 family protein 0.0112 0.1232 0.4228
Schistosoma mansoni smad1 5 8 and 0.001 0.005 0.0053
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0129 0.0093
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.0963 0.3297
Brugia malayi RNA recognition motif domain containing protein 0.0197 0.2208 0.4105
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0301 0.054
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0301 0.0692
Schistosoma mansoni DNA polymerase eta 0.0021 0.0177 0.0188
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0112 0.1232 0.228
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0024 0.0209 0.0041
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0024 0.0209 0.037
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0089 0.0963 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0024 0.0209 0.0326
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0024 0.0209 0.0326
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0024 0.0209 0.0686
Mycobacterium tuberculosis Conserved protein 0.0112 0.1232 0.1314
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0301 0.054
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0109 0.0181
Giardia lamblia Fructose-bisphosphate aldolase 0.0304 0.3434 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0301 0.054
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0304 0.3434 1
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0301 0.0496
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0024 0.0209 0.0686
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0301 0.0496
Brugia malayi CXXC zinc finger family protein 0.003 0.028 0.0502
Trichomonas vaginalis apoptosis inducing factor, putative 0.0024 0.0209 0.0569
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0484 0.045
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0109 0.0136
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0024 0.0209 0.0686
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0301 0.054
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0089 0.0963 0.3297
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.0963 0.3297
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0109 0.0181
Echinococcus granulosus Smad4 0.001 0.005 0.0027
Schistosoma mansoni cpg binding protein 0.003 0.028 0.0298
Schistosoma mansoni tar DNA-binding protein 0.0197 0.2208 0.2349
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0301 0.0265
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0109 0.0073
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0177 0.0309
Mycobacterium ulcerans NADH dehydrogenase 0.0024 0.0209 0.1212
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0024 0.0209 0.1212
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0301 0.0496
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.005 0.0014
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0301 0.054
Treponema pallidum NADH oxidase 0.0089 0.0963 0.2337
Plasmodium falciparum glutathione reductase 0.0257 0.2897 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0586 0.669 0.811
Mycobacterium tuberculosis Probable oxidoreductase 0.0652 0.7443 0.9049
Echinococcus granulosus muscleblind protein 0.0471 0.5363 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1597 0.2964
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0024 0.0209 0.0569
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0301 0.054
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0089 0.0963 0.3297
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0024 0.0209 0.0041
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0129 0.0137
Schistosoma mansoni tar DNA-binding protein 0.0197 0.2208 0.2349
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.1232 0.3559
Echinococcus multilocularis Smad4 0.001 0.005 0.0014
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0209 0.0569
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0484 0.0842
Loa Loa (eye worm) hypothetical protein 0.0471 0.5363 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0024 0.0209 0.0174
Trypanosoma brucei trypanothione reductase 0.0257 0.2897 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0177 0.0572
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0024 0.0209 0.0041
Loa Loa (eye worm) hypothetical protein 0.0015 0.0109 0.0181
Toxoplasma gondii selenide, water dikinase 0.0024 0.0209 0.0686
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0209 0.0569
Loa Loa (eye worm) programmed cell death 8 0.0024 0.0209 0.037
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0301 0.054
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0112 0.1232 0.1314
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.005 0.0072
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.1232 0.131
Brugia malayi MH2 domain containing protein 0.0144 0.1597 0.2964
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0209 0.0569
Trypanosoma cruzi NADH dehydrogenase, putative 0.0024 0.0209 0.0686
Schistosoma mansoni tar DNA-binding protein 0.0197 0.2208 0.2349
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0301 0.0496
Loa Loa (eye worm) hypothetical protein 0.0015 0.0109 0.0181
Leishmania major DNA polymerase kappa, putative 0.0021 0.0177 0.0572
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0089 0.0963 0.3297
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0109 0.0136
Loa Loa (eye worm) hypothetical protein 0.0032 0.0301 0.054
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0089 0.0963 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0089 0.0963 1
Mycobacterium tuberculosis Probable hydrolase 0.0112 0.1232 0.1314
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0301 0.032
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0301 0.054
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0177 0.0572
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0024 0.0209 0.0326
Leishmania major NADH dehydrogenase, putative 0.0024 0.0209 0.0686
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0036 0.0038
Schistosoma mansoni smad 0.001 0.005 0.0053
Loa Loa (eye worm) hypothetical protein 0.0015 0.0109 0.0181
Entamoeba histolytica thioredoxin reductase, putative 0.0024 0.0209 0.0101
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0024 0.0209 0.0686
Brugia malayi glutathione reductase 0.0257 0.2897 0.5393
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0315 0.0335
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0089 0.0963 0.1024
Schistosoma mansoni glutamate synthase 0.0024 0.0209 0.0223
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0301 0.0265
Brugia malayi Thioredoxin reductase 0.0257 0.2897 0.5393
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0024 0.0209 0.0326
Loa Loa (eye worm) histone methyltransferase 0.001 0.0057 0.0085
Schistosoma mansoni disulfide oxidoreductase 0.0024 0.0209 0.0223
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0301 0.0265
Plasmodium vivax ferrodoxin reductase, putative 0.0024 0.0209 0.0686
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0089 0.0963 0.3297
Giardia lamblia DINP protein human, muc B family 0.0021 0.0177 0.0483
Mycobacterium ulcerans hypothetical protein 0.0112 0.1232 0.7468
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0024 0.0209 0.0686
Trypanosoma brucei unspecified product 0.0021 0.0177 0.0572
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1232 0.3559
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0301 0.0265
Leishmania major trypanothione reductase 0.0257 0.2897 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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