Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | ap endonuclease, putative | 0.0042 | 0.4398 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0042 | 0.4398 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0042 | 0.4398 | 0.4398 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0042 | 0.4398 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0042 | 0.4398 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0042 | 0.4398 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0042 | 0.4398 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0042 | 0.4398 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0042 | 0.4398 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0042 | 0.4398 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0042 | 0.4398 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0042 | 0.4398 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0042 | 0.4398 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0042 | 0.4398 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0042 | 0.4398 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0061 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0038 | 0.3293 | 0.3293 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0042 | 0.4398 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0042 | 0.4398 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0042 | 0.4398 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0042 | 0.4398 | 0.4398 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0042 | 0.4398 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0042 | 0.4398 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.2387 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.