TDR Targets

Basic information

Technical information

TDR Targets ID: 1533335
Name: methyl 2-[4-(1,3-benzodioxol-5-ylmethylsulfam oyl)phenoxy]acetate
MW: 379.384 | Formula: C17H17NO7S
H donors: 1 H acceptors: 3 LogP: 2.09 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)COc1ccc(cc1)S(=O)(=O)NCc1ccc2c(c1)OCO2
InChi: 1S/C17H17NO7S/c1-22-17(19)10-23-13-3-5-14(6-4-13)26(20,21)18-9-12-2-7-15-16(8-12)25-11-24-15/h2-8,18H,9-11H2,1H3
InChiKey: ARCUCLJIQSIYQF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[4-(1,3-benzodioxol-5-ylmethylsulfamoyl)phenoxy]acetic acid methyl ester
methyl 2-[4-(1,3-benzodioxol-5-ylmethylsulfamoyl)phenoxy]ethanoate
BAS 07561517
{4-[(Benzo[1,3]dioxol-5-ylmethyl)-sulfamoyl]-phenoxy}-acetic acid methyl ester
ZINC00810148

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0009	0.0091	0.0092
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0024	0.054	0.7492
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0367	0.0348
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0046	0.0637
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0007	0.0046	0.0546
Loa Loa (eye worm)	sodium/potassium-transporting ATPase subunit alpha	0.0009	0.0091	0.0072
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0009	0.0091	0.0092
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.072	0.9082
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0023	0.0496	0.9022
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.0496	0.5
Mycobacterium ulcerans	metal cation-transporting p-type ATPase CtpC	0.0009	0.0091	0.089
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0545	0.0527
Loa Loa (eye worm)	calcium ATPase	0.0009	0.0091	0.0072
Schistosoma mansoni	ATPase	0.0009	0.0091	0.0091
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0007	0.0046	0.0035
Brugia malayi	Bloom's syndrome protein homolog	0.0026	0.0604	0.0752
Trypanosoma cruzi	Calcium ATPase SERCA-like	0.0009	0.0091	0.1254
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0545	1
Trichomonas vaginalis	cation-transporting ATPase fungi, putative	0.0009	0.0091	0.0092
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0046	0.0027
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0007	0.0046	0.0549
Schistosoma mansoni	acetyl-CoA synthetase	0.0007	0.0046	0.0046
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0024	0.054	0.0521
Echinococcus granulosus	importin subunit beta 1	0.0033	0.0791	0.0773
Echinococcus multilocularis	cation transporting ATPase 13A3	0.0009	0.0091	0.0072
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0496	0.6184
Echinococcus multilocularis	phosphoserine phosphatase	0.0009	0.0091	0.0072
Toxoplasma gondii	HEAT repeat-containing protein	0.0006	0.0019	0.0226
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0046	0.0035
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.0844	0.0827
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0496	0.5786
Entamoeba histolytica	cation-transporting P-typeATPase, putative	0.0009	0.0091	0.1486
Mycobacterium tuberculosis	Probable metal cation transporter ATPase P-type CtpE	0.0009	0.0091	0.1388
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0046	0.0637
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0014	0.0248	0.2963
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 1	0.0009	0.0091	0.0929
Plasmodium vivax	SET domain protein, putative	0.0035	0.0844	1
Echinococcus granulosus	phospholipid transporting ATPase VA	0.0009	0.0091	0.0072
Trypanosoma cruzi	copper-transporting ATPase-like protein, putative	0.0009	0.0091	0.1254
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0011	0.0155	0.0136
Echinococcus granulosus	copper transporting ATPase 1	0.0009	0.0091	0.0072
Brugia malayi	potential phospholipid-transporting ATPase IIB, putative	0.0009	0.0091	0.0092
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0007	0.0046	0.0354
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER ATPASE I CTPI	0.0009	0.0091	0.089
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0844	0.0844
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0009	0.0091	0.0092
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0046	0.0546
Loa Loa (eye worm)	Na,K-ATPase alpha subunit	0.0009	0.0091	0.0072
Trypanosoma brucei	P-type H+-ATPase, putative	0.0009	0.0091	0.0929
Trichomonas vaginalis	ran, putative	0.0024	0.054	0.0668
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0007	0.0046	0.0354
Loa Loa (eye worm)	oxidoreductase	0.0007	0.0046	0.0027
Trichomonas vaginalis	phospholipid-transporting ATPase, putative	0.0009	0.0091	0.0092
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.1349	0.1349
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0545	1
Mycobacterium tuberculosis	Cation transporter P-type ATPase a CtpA	0.0009	0.0091	0.1388
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0007	0.0046	0.0637
Echinococcus multilocularis	phospholipid transporting ATPase IIB	0.0009	0.0091	0.0072
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.072	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0367	0.6617
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0046	0.0354
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0009	0.0091	0.1486
Plasmodium vivax	P-type ATPase4, putative	0.0009	0.0091	0.0869
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2463	0.2449
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0011	0.0155	0.0136
Plasmodium vivax	copper-transporting ATPase, putative	0.0009	0.0091	0.0869
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0844	0.0844
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0338	0.6071
Mycobacterium ulcerans	metal cation transporter ATPase p-type CtpE	0.0009	0.0091	0.089
Brugia malayi	haloacid dehalogenase-like hydrolase family protein	0.0009	0.0091	0.0092
Leishmania major	importin beta-1 subunit, putative	0.0027	0.0611	0.8482
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0545	1
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.072	0.9082
Schistosoma mansoni	importin-beta 2	0.0006	0.0019	0.0019
Trypanosoma cruzi	phospholipid-transporting ATPase-like protein, putative	0.0009	0.0091	0.1254
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0046	0.0035
Onchocerca volvulus		0.0009	0.0091	0.0057
Onchocerca volvulus		0.0056	0.1463	0.1824
Trichomonas vaginalis	set domain proteins, putative	0.0276	0.7814	1
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0014	0.0234	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0133	0.369	0.3678
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0009	0.0091	0.0092
Echinococcus granulosus	histone lysine methyltransferase setb	0.0035	0.0844	0.0827
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0009	0.0091	0.1254
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.0496	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0367	0.0348
Echinococcus granulosus	sarco:endoplasmic reticulum calcium ATPase	0.0009	0.0091	0.0072
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.072	0.8531
Trypanosoma cruzi	proton motive ATPase 1, putative	0.0009	0.0091	0.1254
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0009	0.0091	0.1486
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0545	1
Brugia malayi	hypothetical protein	0.0275	0.78	1
Leishmania major	acetyl-CoA synthetase, putative	0.0007	0.0046	0.0637
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0338	0.6071
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0018	0.0356	0.4088
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0007	0.0046	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0367	0.0348
Toxoplasma gondii	phospholipid-translocating P-type ATPase, flippase subfamily protein	0.0009	0.0091	0.1075
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0009	0.0091	0.1254
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0009	0.0091	0.0092
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0009	0.0091	0.1254
Plasmodium vivax	calcium-transporting ATPase, putative	0.0009	0.0091	0.0869
Mycobacterium ulcerans	metal cation transporter p-type ATPase, CtpV	0.0009	0.0091	0.089
Mycobacterium tuberculosis	Probable cation transporter P-type ATPase D CtpD	0.0009	0.0091	0.1388
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0545	0.0676
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0545	1
Entamoeba histolytica	hypothetical protein	0.0027	0.0611	1
Echinococcus multilocularis	phosphoserine phosphatase	0.0009	0.0091	0.0072
Schistosoma mansoni	importin beta-1	0.0033	0.0791	0.0791
Leishmania major	hypothetical protein, conserved	0.0006	0.0019	0.0257
Entamoeba histolytica	HEAT repeat domain containing protein	0.0006	0.0019	0.0312
Brugia malayi	Pre-SET motif family protein	0.0242	0.6846	0.8773
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0791	1
Echinococcus granulosus	cation transporting ATPase 13A3	0.0009	0.0091	0.0072
Schistosoma mansoni	copper ABC transporter ATPase	0.0009	0.0091	0.0091
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0496	0.0612
Schistosoma mansoni	cation-transporting ATPase	0.0009	0.0091	0.0091
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0024	0.054	0.0521
Brugia malayi	Importin beta-1 subunit	0.0033	0.0791	0.0992
Brugia malayi	hypothetical protein	0.003	0.072	0.0901
Schistosoma mansoni	DNA helicase recq5	0.0011	0.0155	0.0155
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0496	0.0612
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0007	0.0046	0.0331
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0024	0.054	1
Echinococcus multilocularis	cation transporting atpase worm	0.0009	0.0091	0.0072
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0023	0.0511	0.6376
Echinococcus multilocularis	cation transporting ATPase 13A1	0.0009	0.0091	0.0072
Leishmania major	GTP-binding protein, putative	0.0024	0.054	0.7492
Plasmodium vivax	cation transporting ATPase, putative	0.0009	0.0091	0.0869
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0024	0.054	0.0521
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0046	0.0027
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0545	0.7569
Brugia malayi	Probable cation-transporting ATPase C10C6.6 in chromosome IV	0.0009	0.0091	0.0092
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.0807	0.079
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0611	0.0759
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0009	0.0091	0.1254
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0367	0.0348
Trypanosoma cruzi	copper-transporting ATPase-like protein, putative	0.0009	0.0091	0.1254
Brugia malayi	E1-E2 ATPase family protein	0.0009	0.0091	0.0092
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0046	0.0035
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0545	1
Mycobacterium ulcerans	cation-transporter p-type ATPase B CtpB	0.0009	0.0091	0.089
Brugia malayi	hypothetical protein	0.0091	0.2463	0.3141
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0091	0.0072
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0545	1
Mycobacterium tuberculosis	Probable metal cation transporter P-type ATPase CtpV	0.0009	0.0091	0.1388
Leishmania major	hypothetical protein, conserved	0.003	0.072	1
Echinococcus multilocularis	snurportin 1	0.0351	1	1
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0009	0.0091	0.0092
Brugia malayi	RNA, U transporter 1	0.0094	0.2546	0.3247
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0496	0.0478
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.1349	0.1332
Leishmania major	copper-transporting ATPase-like protein, putative	0.0009	0.0091	0.1254
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0496	0.0478
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0545	1
Trichomonas vaginalis	ATPase, class I, type 8B, putative	0.0009	0.0091	0.0092
Plasmodium falciparum	copper-transporting ATPase	0.0009	0.0091	0.0929
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0035	0.0844	1
Trichomonas vaginalis	DNA helicase recq1, putative	0.0026	0.0604	0.075
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0007	0.0046	0.0549
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0007	0.0046	0.0546
Trypanosoma brucei	cation-transporting ATPase, putative	0.0009	0.0091	0.0929
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.1349	0.1709
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0007	0.0046	0.0027
Trypanosoma brucei	copper-transporting ATPase-like protein, putative	0.0009	0.0091	0.0929
Entamoeba histolytica	calcium-transporting P-type ATPase, putative	0.0009	0.0091	0.1486
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB	0.0009	0.0091	0.089
Toxoplasma gondii	cation-transporting atpase family protein	0.0009	0.0091	0.1075
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0338	0.6071
Echinococcus multilocularis	phosphoserine phosphatase	0.0009	0.0091	0.0072
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0007	0.0046	0.0637
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0011	0.0155	0.1759
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0009	0.0091	0.0092
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0024	0.054	0.0669
Echinococcus granulosus	calcium transporting ATPase type 2C member	0.0009	0.0091	0.0072
Entamoeba histolytica	plasma membrane calcium-transporting ATPase 1, putative	0.0009	0.0091	0.1486
Trichomonas vaginalis	importin beta-1, putative	0.0027	0.0611	0.0759
Echinococcus granulosus	bloom syndrome protein	0.0026	0.0604	0.0586
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0496	0.0613
Leishmania major	proton motive ATPase, putative	0.0009	0.0091	0.1254
Leishmania major	P-type H -ATPase, putative	0.0009	0.0091	0.1254
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.1349	0.1332
Schistosoma mansoni	type V p-type atpase isoform	0.0009	0.0091	0.0091
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0009	0.0091	0.1486
Echinococcus multilocularis	phospholipid transporting ATPase VA	0.0009	0.0091	0.0072
Echinococcus granulosus	cation transporting atpase worm	0.0009	0.0091	0.0072
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0035	0.0844	0.0844
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0155	0.1834
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0545	0.8924
Schistosoma mansoni	blooms syndrome DNA helicase	0.0021	0.0443	0.0443
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0009	0.0091	0.1486
Mycobacterium ulcerans	metal cation-transporting p-type ATPase F, CtpF	0.0009	0.0091	0.089
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0545	0.0527
Brugia malayi	hypothetical protein	0.0009	0.0091	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0091	0.0072
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.0496	0.9076
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.0009	0.0091	0.0091
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0056	0.1463	0.1856
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0046	0.0546
Schistosoma mansoni	phosphoserine phosphatase	0.0009	0.0091	0.0091
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 2	0.0009	0.0091	0.0929
Toxoplasma gondii	propionate-CoA ligase	0.0007	0.0046	0.0549
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0545	0.8924
Brugia malayi	Na,K-ATPase alpha subunit	0.0009	0.0091	0.0092
Schistosoma mansoni	hypothetical protein	0.0351	1	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0091	0.0072
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0009	0.0091	0.0092
Schistosoma mansoni	survival motor neuron protein	0.0056	0.1463	0.1463
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0009	0.0091	0.1254
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0496	0.6891
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0024	0.054	0.7492
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.0496	0.9038
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0844	0.0827
Schistosoma mansoni	cation-transporting atpase worm	0.0009	0.0091	0.0091
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0046	0.0637
Trypanosoma brucei	vacuolar-type Ca2+-ATPase, putative	0.0009	0.0091	0.0929
Echinococcus multilocularis	calcium transporting ATPase type 2C member	0.0009	0.0091	0.0072
Toxoplasma gondii	phospholipid-translocating P-type ATPase, flippase subfamily protein	0.0009	0.0091	0.1075
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0545	0.0676
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0545	1
Entamoeba histolytica	Ran family GTPase	0.0024	0.054	0.8833
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0007	0.0046	0.0027
Trichomonas vaginalis	DNA helicase recq, putative	0.0014	0.0248	0.0293
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0367	0.4503
Brugia malayi	E1-E2 ATPase family protein	0.0009	0.0091	0.0092
Entamoeba histolytica	recQ family helicase, putative	0.0014	0.0248	0.4056
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0009	0.0091	0.0092
Trichomonas vaginalis	DNA helicase recq, putative	0.0026	0.0604	0.075
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.1349	0.1332
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0242	0.6846	0.684
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.1349	0.1332
Mycobacterium tuberculosis	Possible metal cation transporting P-type ATPase CtpH	0.0009	0.0091	0.1388
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0014	0.0248	0.3435
Echinococcus multilocularis	phosphoserine phosphatase	0.0009	0.0091	0.0072
Loa Loa (eye worm)	RecQ helicase	0.0026	0.0604	0.0586
Echinococcus granulosus	survival motor neuron protein 1	0.0275	0.78	0.7796
Brugia malayi	hypothetical protein	0.002	0.0408	0.05
Trypanosoma cruzi	copper-transporting ATPase-like protein, putative	0.0009	0.0091	0.1254
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0791	1
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0009	0.0091	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2463	0.2449
Trichomonas vaginalis	ATPase, class VI, type 11C, putative	0.0009	0.0091	0.0092
Leishmania major	calcium-translocating P-type ATPase	0.0009	0.0091	0.1254
Plasmodium falciparum	non-SERCA-type Ca2+ -transporting P-ATPase	0.0009	0.0091	0.0929
Schistosoma mansoni	hypothetical protein	0.0014	0.0234	0.0234
Toxoplasma gondii	P-type ATPase4, putative	0.0009	0.0091	0.1075
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0011	0.0155	0.0136
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0011	0.0155	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0091	0.0072
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0155	0.0174
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0611	0.0759
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0011	0.0155	0.0136
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0007	0.0046	0.0546
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0351	1	1
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0155	0.0174
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0496	0.6184
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0545	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0046	0.0027
Schistosoma mansoni	ran	0.0024	0.054	0.054
Schistosoma mansoni	cation-transporting atpase worm	0.0009	0.0091	0.0091
Leishmania major	acetyl-CoA synthetase, putative	0.0007	0.0046	0.0637
Onchocerca volvulus		0.0035	0.0844	0.1027
Brugia malayi	Pre-SET motif family protein	0.0035	0.0844	0.106
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0496	0.6891
Echinococcus multilocularis	copper transporting ATPase 1	0.0009	0.0091	0.0072
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0545	0.7569
Mycobacterium ulcerans	cation-transporter ATPase I CtpI	0.0009	0.0091	0.089
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0046	0.0027
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0009	0.0091	0.1486
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.1349	0.1349
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.0496	0.8126
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0496	0.0478
Toxoplasma gondii	heavy metal translocating P-type ATPase subfamily protein	0.0009	0.0091	0.1075
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0496	0.6891
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0024	0.054	0.6744
Toxoplasma gondii	calcium-translocating P-type ATPase, PMCA-type protein	0.0009	0.0091	0.1075
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.072	0.8497
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0024	0.054	0.6744
Toxoplasma gondii	P-type ATPase PMA1	0.0009	0.0091	0.1075
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0007	0.0046	0.0546
Plasmodium falciparum	importin beta, putative	0.0033	0.0791	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0006	0.0019	0.0226
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0046	0.0035
Toxoplasma gondii	exonuclease III APE	0.0023	0.0496	0.5881
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.1349	0.1349
Schistosoma mansoni	ATPase	0.0009	0.0091	0.0091
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0545	1
Echinococcus granulosus	phospholipid transporting ATPase IIB	0.0009	0.0091	0.0072
Toxoplasma gondii	HEAT repeat-containing protein	0.0033	0.0791	0.937
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0027	0.0611	0.8482
Echinococcus granulosus	plasma membrane calcium transporting ATPase 2	0.0009	0.0091	0.0072
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0024	0.054	0.6309
Echinococcus multilocularis	Tetracycline resistance leader peptide, TetL	0.0009	0.0091	0.0072
Onchocerca volvulus		0.0276	0.7814	1
Mycobacterium ulcerans	cation transporter p-type ATPase D CtpD	0.0009	0.0091	0.089
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.0009	0.0091	0.1486
Schistosoma mansoni	ran	0.0024	0.054	0.054
Onchocerca volvulus		0.0024	0.0545	0.0642
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0009	0.0091	0.1486
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0844	0.0844
Echinococcus multilocularis	sarco:endoplasmic reticulum calcium ATPase	0.0009	0.0091	0.0072
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0367	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0035	0.0844	0.0827
Echinococcus multilocularis	phosphoserine phosphatase	0.0009	0.0091	0.0072
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0009	0.0091	0.1254
Echinococcus granulosus	cation transporting ATPase 13A1	0.0009	0.0091	0.0072
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0018	0.035	0.4149
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0046	0.0035
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0545	0.0676
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0545	0.7569
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0367	0.4213
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0545	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0155	0.0136
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0046	0.0546
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.072	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0155	0.1834
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0014	0.0234	0.0216
Schistosoma mansoni	cation-transporting atpase 13a1 (G-box binding protein)	0.0009	0.0091	0.0091
Toxoplasma gondii	haloacid dehalogenase family hydrolase domain-containing protein	0.0009	0.0091	0.1075
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0545	0.0527
Schistosoma mansoni	eyes absent homolog	0.0091	0.2463	0.2463
Leishmania major	P-type H -ATPase, putative	0.0009	0.0091	0.1254
Schistosoma mansoni	ap endonuclease	0.0023	0.0496	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0367	0.0348
Mycobacterium ulcerans	cation transporter p-type ATPase a CtpA	0.0009	0.0091	0.089
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0024	0.054	0.6393
Toxoplasma gondii	haloacid dehalogenase family hydrolase domain-containing protein	0.0009	0.0091	0.1075
Trypanosoma cruzi	cation-transporting ATPase, putative	0.0009	0.0091	0.1254
Schistosoma mansoni	DNA helicase recq1	0.0011	0.0155	0.0155
Schistosoma mansoni	hypothetical protein	0.0056	0.1463	0.1463
Loa Loa (eye worm)	hypothetical protein	0.0275	0.78	0.7796
Mycobacterium leprae	Probable metal cation-transporting P-type ATPase C CtpC	0.0009	0.0091	0.089
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.072	0.9082
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0791	0.0773
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0367	0.6421
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0014	0.0248	0.3435
Schistosoma mansoni	atpase class VI type 11c	0.0009	0.0091	0.0091
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0046	0.0546
Loa Loa (eye worm)	E1-E2 ATPase	0.0009	0.0091	0.0072
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0338	0.6071
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0545	0.8924
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0007	0.0046	0.0759
Mycobacterium ulcerans	metal cation transporter p-type ATPase a	0.0009	0.0091	0.089
Trypanosoma brucei	P-type H+-ATPase, putative	0.0009	0.0091	0.0929
Echinococcus multilocularis	bloom syndrome protein	0.0026	0.0604	0.0586
Echinococcus multilocularis	survival motor neuron protein 1	0.0275	0.78	0.7796
Loa Loa (eye worm)	hypothetical protein	0.003	0.072	0.0702
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0091	0.0072
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.1349	0.1332
Toxoplasma gondii	sarco/endoplasmic reticulum Ca2+-ATPase	0.0009	0.0091	0.1075
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0007	0.0046	0.0546
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0007	0.0046	0.0035
Giardia lamblia	Sgs1 DNA helicase, putative	0.0011	0.0155	0.1428
Brugia malayi	Sodium/potassium-transporting ATPase alpha chain, putative	0.0009	0.0091	0.0092
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0046	0.0035
Schistosoma mansoni	ap endonuclease	0.0023	0.0496	0.0496
Plasmodium vivax	importin-beta 2, putative	0.0033	0.0791	0.9355
Trypanosoma cruzi	copper-transporting ATPase, putative	0.0009	0.0091	0.1254
Echinococcus multilocularis	importin subunit beta 1	0.0033	0.0791	0.0773
Echinococcus multilocularis	phosphoserine phosphatase	0.0009	0.0091	0.0072
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0007	0.0046	0.0546

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.006 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.3359 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	2.0787 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1710684

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1533335