Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 1 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.6512 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.6512 | 0.6512 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.6512 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.6512 | 0.6512 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.6512 | 0.6512 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.6512 | 0.6512 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.6512 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.6512 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.6512 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1158 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.