Detailed information for compound 1533973

Basic information

Technical information
  • TDR Targets ID: 1533973
  • Name: 2-[(5-chloro-2-methoxyphenyl)-methylsulfonyla mino]-N-[2-(morpholine-4-carbonyl)phenyl]acet amide
  • MW: 481.95 | Formula: C21H24ClN3O6S
  • H donors: 1 H acceptors: 4 LogP: 2.21 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1N(S(=O)(=O)C)CC(=O)Nc1ccccc1C(=O)N1CCOCC1)Cl
  • InChi: 1S/C21H24ClN3O6S/c1-30-19-8-7-15(22)13-18(19)25(32(2,28)29)14-20(26)23-17-6-4-3-5-16(17)21(27)24-9-11-31-12-10-24/h3-8,13H,9-12,14H2,1-2H3,(H,23,26)
  • InChiKey: NUAZXUXXDHVASC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(5-chloro-2-methoxy-phenyl)-methylsulfonyl-amino]-N-[2-(morpholine-4-carbonyl)phenyl]acetamide
  • 2-[(5-chloro-2-methoxyphenyl)-methylsulfonylamino]-N-[2-(morpholino-oxomethyl)phenyl]acetamide
  • 2-[(5-chloro-2-methoxy-phenyl)-mesyl-amino]-N-[2-(morpholine-4-carbonyl)phenyl]acetamide
  • 2-[(5-chloro-2-methoxy-phenyl)-methylsulfonyl-amino]-N-(2-morpholin-4-ylcarbonylphenyl)ethanamide
  • ZINC02856994

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens snurportin 1 No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0591 0.0591
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0591 1
Brugia malayi hypothetical protein 0.002 0.0168 0.0205
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0077 0.0077
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0469 0.2232
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0936 1
Echinococcus multilocularis geminin 0.0176 0.4531 0.4531
Echinococcus granulosus neuropeptide receptor 0.0173 0.4446 0.4446
Loa Loa (eye worm) hypothetical protein 0.0035 0.0609 0.0536
Echinococcus multilocularis snurportin 1 0.0372 1 1
Brugia malayi RNA, U transporter 1 0.0099 0.2384 0.5208
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.4507 0.4507
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.3268 0.3268
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0407 0.542
Schistosoma mansoni hypothetical protein 0.0176 0.4531 0.4531
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0591 0.3557
Loa Loa (eye worm) hypothetical protein 0.0127 0.3177 0.3124
Brugia malayi hypothetical protein 0.0127 0.3177 0.6999
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.2341 0.2341
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0407 0.1009
Schistosoma mansoni hypothetical protein 0.0016 0.0077 0.0077
Schistosoma mansoni thyroid hormone receptor 0.0141 0.3561 0.3561
Schistosoma mansoni neuropeptide receptor 0.0173 0.4446 0.4446
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.1056 1
Schistosoma mansoni hypothetical protein 0.0016 0.0077 0.0077
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0469 0.5234
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.1056 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.2341 0.2341
Schistosoma mansoni ran 0.0026 0.0334 0.0334
Schistosoma mansoni importin beta-1 0.0035 0.0591 0.0591
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0334 0.0334
Plasmodium falciparum importin beta, putative 0.0035 0.0591 0.4265
Schistosoma mansoni hypothetical protein 0.0035 0.0609 0.0609
Onchocerca volvulus Huntingtin homolog 0.0127 0.3177 0.5
Onchocerca volvulus Huntingtin homolog 0.0127 0.3177 0.5
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0334 0.0581
Echinococcus multilocularis thyroid hormone receptor alpha 0.0141 0.3561 0.3561
Echinococcus granulosus geminin 0.0176 0.4531 0.4531
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.2341 0.2282
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.1056 0.1056
Echinococcus multilocularis neuropeptide receptor 0.0173 0.4446 0.4446
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.2341 0.2341
Leishmania major importin beta-1 subunit, putative 0.0028 0.0407 0.542
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0469 0.2232
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.4507 0.4507
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0469 0.1862
Leishmania major hypothetical protein, conserved 0.003 0.0469 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0077 0.0077
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0591 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.1067 0.0998
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0609 0.12
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.437 0.437
Echinococcus multilocularis G protein coupled receptor 139 0.0173 0.4446 0.4446
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.1067 0.0998
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.3268 0.3268
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0334 0.0334
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.2341 0.2341
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0077 0.0077
Loa Loa (eye worm) acetyltransferase 0.0175 0.4507 0.4464
Schistosoma mansoni hypothetical protein 0.0176 0.4531 0.4531
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.1056 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.1056 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0469 0.0395
Loa Loa (eye worm) hypothetical protein 0.0127 0.3177 0.3124
Echinococcus multilocularis GPCR, family 2 0.0016 0.0077 0.0077
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0469 0.1862
Brugia malayi hypothetical protein 0.003 0.0469 0.0885
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.1056 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0077 0.0077
Schistosoma mansoni ran 0.0026 0.0334 0.0334
Entamoeba histolytica hypothetical protein 0.0028 0.0407 0.121
Brugia malayi Importin beta-1 subunit 0.0035 0.0591 0.1161
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0469 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0469 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0936 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.2341 0.2341
Schistosoma mansoni hypothetical protein 0.0016 0.0077 0.0077
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.4507 1
Schistosoma mansoni hypothetical protein 0.0016 0.0077 0.0077
Echinococcus granulosus importin subunit beta 1 0.0035 0.0591 0.0591
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0407 0.1009
Schistosoma mansoni hypothetical protein 0.0131 0.3268 0.3268
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.2341 0.2341
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.1067 0.2234
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.2341 0.5112
Loa Loa (eye worm) hypothetical protein 0.0035 0.0591 0.0518
Plasmodium vivax importin-beta 2, putative 0.0035 0.0591 0.3557
Schistosoma mansoni thyroid hormone receptor 0.0141 0.3561 0.3561
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0334 0.026
Schistosoma mansoni hypothetical protein 0.0372 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.2341 0.2341
Echinococcus granulosus GPCR family 2 0.0016 0.0077 0.0077
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0407 0.1009
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.1067 0.2234
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0936 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 7.3078 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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