Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0043 | 0.908 | 0.879 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.908 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0.2399 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.2399 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.2399 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.2399 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 0.2399 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.2399 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2399 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0.2399 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.2399 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.908 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.908 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2399 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.2399 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0.2399 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.908 | 0.879 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2399 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2399 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.2399 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2399 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.908 | 0.879 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 0.2399 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2399 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2399 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.2399 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.2399 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.2399 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.2399 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2399 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.2399 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2399 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.908 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.2399 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.2399 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.2399 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.908 | 0.879 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.2399 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.908 | 0.879 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.5849 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 4.1095 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.