Detailed information for compound 153412

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 337.455 | Formula: C22H27NO2
  • H donors: 0 H acceptors: 1 LogP: 3.61 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC1(CCN(C(=O)C)C)c2ccccc2CCc2c1cccc2
  • InChi: 1S/C22H27NO2/c1-4-25-22(15-16-23(3)17(2)24)20-11-7-5-9-18(20)13-14-19-10-6-8-12-21(19)22/h5-12H,4,13-16H2,1-3H3
  • InChiKey: URNNMEDZCZESMJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0077 0.0176 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0051 0.0098 0.0108
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0025 0.002
Echinococcus multilocularis GPCR, family 2 0.0293 0.0833 0.0826
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0049 0.0093 0.0103
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0073 0.0166 0.0522
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0031 0.0027
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0031 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0051 0.0098 0.0108
Brugia malayi ecdysone receptor 0.0024 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.001
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.006 0.0125 0.0114
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0016 0.0019
Echinococcus multilocularis chromobox protein 1 0.0072 0.0163 0.0155
Schistosoma mansoni 6-phosphogluconolactonase 0.0034 0.0047 0.0057
Loa Loa (eye worm) hypothetical protein 0.0073 0.0166 0.019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0016 0.001
Brugia malayi Pre-SET motif family protein 0.0033 0.0043 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0051 0.0098 0.0108
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.005 0.0051
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0051 0.0098 0.0117
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.0069 0.0073
Leishmania major 6-phosphogluconolactonase 0.0034 0.0047 0.0047
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.2755 0.8325 1
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.2755 0.8325 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0242 0.0281
Schistosoma mansoni zinc finger protein 0.0041 0.0067 0.0081
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0029 0.0031 0.0105
Trypanosoma brucei PAB1-binding protein , putative 0.0185 0.0506 0.0599
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0016 0.0008
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0029 0.0031 0.0043
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.2755 0.8325 1
Brugia malayi hypothetical protein 0.0024 0.0016 0.001
Schistosoma mansoni bromodomain containing protein 0.0128 0.0333 0.04
Echinococcus granulosus Smad4 0.0033 0.0044 0.0043
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0049 0.0093 0.0112
Echinococcus multilocularis microtubule associated protein 2 0.0678 0.2005 0.1999
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.0478 0.3528
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0029 0.0031 0.0043
Entamoeba histolytica hypothetical protein 0.0075 0.017 0.0747
Brugia malayi GH02984p 0.035 0.1008 0.1203
Onchocerca volvulus 0.0039 0.0062 0.0354
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0031 0.0027
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.065 0.0772
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0076 0.0455
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0038 0.0036
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0062 0.0065
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0051 0.0098 0.0625
Echinococcus multilocularis tumor protein p63 0.0348 0.1001 0.0994
Brugia malayi hypothetical protein 0.0037 0.0056 0.0058
Echinococcus granulosus GPCR family 2 0.0293 0.0833 0.0992
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0125 0.0139
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0015 0.0008
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0062 0.0154
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0098 0.009
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0098 0.0242 0.6878
Echinococcus granulosus transcription factor btf3 0.0216 0.0599 0.071
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0016 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0506 0.0592
Brugia malayi Transient-receptor-potential like protein 0.0038 0.0058 0.006
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0083 0.0196 0.0223
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0044 0.0043
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0031 0.0028
Brugia malayi 6-phosphogluconolactonase family protein 0.0034 0.0047 0.0047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0422 0.1226 0.1473
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0051 0.0098 0.0108
Schistosoma mansoni hypothetical protein 0.0075 0.017 0.0204
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0065
Toxoplasma gondii isocitrate dehydrogenase 0.0083 0.0196 0.0223
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0039 0.0037
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0733 0.2172 1
Mycobacterium ulcerans hypothetical protein 0.0098 0.0242 0.0255
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0029 0.0031 0.0043
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0039 0.006 0.0053
Onchocerca volvulus 0.0039 0.006 0.034
Brugia malayi nuclear receptor NHR-88 0.0051 0.0098 0.0108
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0051 0.0098 0.009
Brugia malayi Steroid receptor seven-up type 2 0.0051 0.0098 0.0108
Brugia malayi MH2 domain containing protein 0.0033 0.0044 0.0043
Brugia malayi nuclear receptor NHR-88 0.0024 0.0016 0.001
Loa Loa (eye worm) ICD-1 protein 0.0216 0.0599 0.071
Loa Loa (eye worm) hypothetical protein 0.0051 0.0098 0.0108
Brugia malayi beta-lactamase 0.0039 0.0062 0.0065
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0098 0.0117
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0887 0.264 0.3165
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0125 0.0139
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0076 0.008
Echinococcus multilocularis zinc finger protein 0.0041 0.0067 0.0059
Leishmania major importin beta-1 subunit, putative 0.0024 0.0015 0.0008
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0051 0.0098 0.0117
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0062 0.0154
Echinococcus granulosus cpg binding protein 0.0035 0.0049 0.0049
Giardia lamblia PHD finger protein 15 0.0032 0.0039 0.0037
Giardia lamblia Glucosamine-6-phosphate deaminase 0.0034 0.0047 0.0047
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0049 0.0093 0.0086
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0293 0.0833 0.0992
Leishmania major 4-coumarate:coa ligase-like protein 0.0098 0.0242 0.0281
Echinococcus granulosus solute carrier family 5 0.0039 0.006 0.0063
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.279 0.8429 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0043 0.0042
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0031 0.0027
Echinococcus granulosus transcription factor eb 0.0551 0.1619 0.1937
Schistosoma mansoni coup transcription factor 0.0051 0.0098 0.0117
Echinococcus multilocularis high affinity choline transporter 1 0.035 0.1008 0.1001
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0031 0.0027
Loa Loa (eye worm) hypothetical protein 0.0051 0.0098 0.0108
Schistosoma mansoni hypothetical protein 0.0293 0.0833 0.1001
Loa Loa (eye worm) hypothetical protein 0.0051 0.0098 0.0108
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.2755 0.8325 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0051 0.0098 0.0108
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.001
Brugia malayi MH1 domain containing protein 0.0033 0.0044 0.0043
Onchocerca volvulus 0.0049 0.0093 0.0592
Brugia malayi conserved hypotetical protein 0.0024 0.0016 0.001
Brugia malayi hypothetical protein 0.0037 0.0056 0.0058
Schistosoma mansoni 6-phosphogluconolactonase 0.0034 0.0047 0.0057
Loa Loa (eye worm) hypothetical protein 0.0032 0.0039 0.0037
Toxoplasma gondii exonuclease III APE 0.006 0.0125 0.0139
Trypanosoma brucei protein kinase, putative 0.0049 0.0093 0.0103
Brugia malayi isocitrate dehydrogenase 0.0083 0.0196 0.0226
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0016 0.0008
Schistosoma mansoni cpg binding protein 0.0035 0.0049 0.0058
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0031 0.0027
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0049 0.0093 0.0103
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0098 0.0242 0.0255
Echinococcus granulosus geminin 0.1908 0.5746 0.6899
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0025 0.002
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0025 0.0017
Entamoeba histolytica transcription factor BTF3, putative 0.0216 0.0599 0.2729
Echinococcus multilocularis cpg binding protein 0.0035 0.0049 0.0041
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.006 0.0125 0.0141
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0087 0.0095
Schistosoma mansoni high-affinity choline transporter 0.035 0.1008 0.1211
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0098 0.0108
Brugia malayi MH2 domain containing protein 0.0033 0.0044 0.0043
Echinococcus granulosus high affinity choline transporter 1 0.035 0.1008 0.1203
Loa Loa (eye worm) steroid hormone receptor 0.0051 0.0098 0.0108
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0034 0.0047 0.0047
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.2755 0.8325 0.8323
Echinococcus granulosus protein kinase shaggy 0.0049 0.0093 0.0103
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0098 0.0242 0.0789
Mycobacterium tuberculosis Conserved protein 0.0039 0.0062 0.0154
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0029 0.0031 0.0027
Brugia malayi tailless protein 0.0024 0.0016 0.001
Echinococcus granulosus short transient receptor potential channel 6 0.0067 0.0148 0.0168
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0098 0.0242 0.6878
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0027
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0016 0.0019
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.0069 0.0061
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.006 0.0125 0.5
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0039 0.0047
Echinococcus multilocularis isocitrate dehydrogenase 0.0083 0.0196 0.0188
Echinococcus multilocularis transcription factor btf3 0.0216 0.0599 0.0591
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0029 0.0031 0.0043
Schistosoma mansoni hypothetical protein 0.0083 0.0195 0.0235
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0044 0.0036
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0251 0.0705 0.2424
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0076 0.0082
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0147 0.0176
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0025 0.003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0293 0.0833 0.0992
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0016 0.001
Schistosoma mansoni nuclear receptor 0.0024 0.0016 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0216 0.0599 0.0701
Trypanosoma brucei transcription factor BTF3, putative 0.0216 0.0599 0.071
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0059 0.0051
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0129 0.0144
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0293 0.0833 0.0992
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0062 0.0065
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.0069 0.0073
Plasmodium falciparum importin beta, putative 0.0029 0.0031 0.0028
Brugia malayi MH2 domain containing protein 0.0486 0.142 0.1698
Brugia malayi jmjC domain containing protein 0.0103 0.0257 0.03
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0478 0.0558
Brugia malayi hypothetical protein 0.0024 0.0016 0.001
Schistosoma mansoni hypothetical protein 0.031 0.0885 0.1063
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0062 0.0154
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.2755 0.8325 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.002
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.18 0.5417 0.6423
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0478 0.0558
Brugia malayi beta-lactamase family protein 0.0039 0.0062 0.0065
Loa Loa (eye worm) hypothetical protein 0.0039 0.006 0.0063
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.279 0.8429 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.0885 0.1055
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0098 0.0242 0.0255
Loa Loa (eye worm) transcription factor SMAD2 0.0486 0.142 0.1698
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0017 0.0011
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.2755 0.8325 1
Brugia malayi AMP-binding enzyme family protein 0.0098 0.0242 0.0281
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0066 0.0384
Brugia malayi nuclear receptor RXR 0.0024 0.0016 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0758 0.089
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0031 0.0043
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0015 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0478 0.0558
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0041 0.0069 0.0072
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0029 0.0031 0.0027
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0039 0.0037
Loa Loa (eye worm) hypothetical protein 0.0034 0.0048 0.0048
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0083 0.0196 0.0226
Schistosoma mansoni survival motor neuron protein 0.0047 0.0087 0.0105
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0016 0.001
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0209 0.0577 0.263
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0422 0.1226 0.122
Loa Loa (eye worm) hypothetical protein 0.0293 0.0833 0.0992
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0154 0.0479
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0293 0.0833 0.0992
Treponema pallidum exodeoxyribonuclease (exoA) 0.006 0.0125 0.0094
Schistosoma mansoni transient receptor potential channel 0.0102 0.0253 0.0304
Giardia lamblia Glucosamine-6-phosphate deaminase 0.0034 0.0047 0.0047
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0093 0.0102
Echinococcus granulosus sodium:glucose cotransporter 0.0039 0.006 0.0063
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0121 0.0311 0.0304
Echinococcus multilocularis solute carrier family 5 0.0039 0.006 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0098 0.0108
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0062 0.0038
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.0257 0.03
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.279 0.8429 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0032 0.0029
Plasmodium vivax glycogen synthase kinase 3, putative 0.0049 0.0093 0.0102
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0758 0.089
Loa Loa (eye worm) hypothetical protein 0.0102 0.0253 0.0294
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0062 0.0038
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0065
Echinococcus multilocularis muscleblind protein 0.1241 0.3718 0.3713
Giardia lamblia Kinase, CMGC GSK 0.0049 0.0093 0.0102
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0163 0.0184
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0083 0.0195 0.0188
Echinococcus granulosus chromobox protein 1 0.0072 0.0163 0.0186
Loa Loa (eye worm) hypothetical protein 0.0925 0.2757 0.3305
Loa Loa (eye worm) beta-lactamase 0.0039 0.0062 0.0065
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.0257 0.0249
Toxoplasma gondii NAC domain-containing protein 0.0216 0.0599 0.0701
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.003 0.0026
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0034 0.0047 0.0182
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0016 0.0008
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0068 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0216 0.0599 0.0701
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0039 0.0037
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0051 0.0098 0.009
Giardia lamblia Kinase, CMGC GSK 0.0049 0.0093 0.0102
Echinococcus granulosus tumor protein p63 0.0348 0.1001 0.1195
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0029 0.0031 0.0027
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0201 0.0554 0.0656
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0125 0.0139
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0031 0.0027
Entamoeba histolytica hypothetical protein 0.0216 0.0599 0.2729
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.063 0.0748
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0031 0.0027
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0956 0.285 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0062 0.0075
Brugia malayi chromobox protein homolog 3 0.0041 0.0066 0.007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0098 0.0108
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0031 0.0027
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.017 0.0162
Schistosoma mansoni tar DNA-binding protein 0.0201 0.0554 0.0665
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.006 0.0125 0.0376
Loa Loa (eye worm) hypothetical protein 0.0073 0.0166 0.019
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0016 0.0008
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0051 0.0098 0.0108
Brugia malayi nuclear hormone receptor 0.0024 0.0016 0.001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0098 0.0242 0.1081
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0016 0.001
Brugia malayi exodeoxyribonuclease III family protein 0.006 0.0125 0.0141
Schistosoma mansoni Smad4 0.0033 0.0044 0.0052
Brugia malayi hypothetical protein 0.0075 0.017 0.0194
Brugia malayi nuclear hormone receptor 0.0051 0.0098 0.0108
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0051 0.0098 0.0108
Entamoeba histolytica hypothetical protein 0.0075 0.017 0.0747
Echinococcus multilocularis 6 phosphogluconolactonase 0.0034 0.0047 0.004
Brugia malayi beta-NAC-like protein 0.0216 0.0599 0.071
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0098 0.0242 0.0789
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.279 0.8429 1
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0049 0.0093 0.0102
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.0069 0.0072
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.279 0.8429 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0154 0.0479
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0031 0.0043
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0031 0.0027
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0548 0.1611 0.1927
Toxoplasma gondii LsmAD domain-containing protein 0.0185 0.0506 0.0591
Brugia malayi Bromodomain containing protein 0.0152 0.0404 0.0477
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0135 0.0162
Mycobacterium ulcerans acyl-CoA synthetase 0.0098 0.0242 0.0255
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0031 0.0028
Brugia malayi glucose-6-phosphate dehydrogenase 0.2755 0.8325 1
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0062 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0758 0.089
Onchocerca volvulus 0.0029 0.0031 0.0113
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0031 0.0043
Echinococcus multilocularis tar DNA binding protein 0.0201 0.0554 0.0546
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0039 0.006 0.0053
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0098 0.0117
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.027 0.0765 0.2638
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.0085 0.0093
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0067 0.0147 0.0139
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.0069 0.0073
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0083 0.0196 0.0226
Loa Loa (eye worm) hypothetical protein 0.1241 0.3718 0.4461
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0031 0.0027
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0015 0.0008
Onchocerca volvulus 0.0051 0.0098 0.0625
Brugia malayi hypothetical protein 0.0027 0.0025 0.002
Brugia malayi Heterochromatin protein 1 0.0072 0.0163 0.0186
Echinococcus multilocularis transcription factor eb 0.0551 0.1619 0.1612
Trichomonas vaginalis conserved hypothetical protein 0.0216 0.0599 0.0701
Loa Loa (eye worm) hypothetical protein 0.0087 0.0207 0.024
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0065
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0044 0.0043
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0083 0.0195 0.0225
Echinococcus multilocularis Smad4 0.0033 0.0044 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0478 0.0558
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0029 0.0031 0.0043
Schistosoma mansoni hypothetical protein 0.0293 0.0833 0.1001
Echinococcus granulosus ecdysone induced protein 78C 0.0051 0.0098 0.0108
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0047 0.0056
Mycobacterium ulcerans acyl-CoA synthetase 0.0098 0.0242 0.0255
Loa Loa (eye worm) 6-phosphogluconolactonase 0.0034 0.0047 0.0047
Echinococcus granulosus snurportin 1 0.031 0.0885 0.1055
Echinococcus multilocularis protein kinase shaggy 0.0049 0.0093 0.0086
Onchocerca volvulus 0.0032 0.004 0.018
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0083 0.0196 0.0226
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0758 0.089
Schistosoma mansoni chromobox protein 0.0072 0.0163 0.0196
Loa Loa (eye worm) hypothetical protein 0.0051 0.0098 0.0108
Loa Loa (eye worm) hypothetical protein 0.0632 0.1866 0.2235
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0422 0.1226 0.1473
Schistosoma mansoni chromobox protein 0.0072 0.0163 0.0196
Schistosoma mansoni hypothetical protein 0.0293 0.0833 0.1001
Loa Loa (eye worm) DR-78 0.0024 0.0016 0.001
Brugia malayi nuclear receptor RXR 0.0027 0.0025 0.002
Brugia malayi RNA, U transporter 1 0.0083 0.0194 0.0224
Brugia malayi Bromodomain containing protein 0.0077 0.0176 0.0202
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0031 0.0028
Loa Loa (eye worm) hypothetical protein 0.0054 0.0107 0.012
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0293 0.0833 0.0826
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0076 0.0082
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.0085 0.0077
Plasmodium falciparum glycogen synthase kinase 3 0.0049 0.0093 0.0102
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0051 0.0098 0.0117
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.0098 0.0117
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0098 0.0108
Onchocerca volvulus 0.0029 0.0031 0.0113
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0031 0.0027
Plasmodium falciparum basic transcription factor 3b, putative 0.0216 0.0599 0.0701
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0038 0.0058 0.005
Schistosoma mansoni hypothetical protein 0.0041 0.0069 0.0082
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0162 0.0154
Schistosoma mansoni smad1 5 8 and 0.0033 0.0044 0.0052
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0051 0.0098 0.0108
Trypanosoma brucei 6-phosphogluconolactonase 0.0034 0.0047 0.0047
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0029 0.0031 0.0027
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0293 0.0833 0.0826
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0098 0.0108
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0422 0.1226 0.122
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0062 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0147 0.0176
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0268 0.0758 0.0902
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.006 0.0125 0.0141
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0039 0.006 0.0053
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0062 0.0065
Loa Loa (eye worm) isocitrate dehydrogenase 0.0083 0.0196 0.0226
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.001
Onchocerca volvulus 0.0047 0.0087 0.0544
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0031 0.0027
Brugia malayi AMP-binding enzyme family protein 0.0098 0.0242 0.0281
Loa Loa (eye worm) hypothetical protein 0.0185 0.0506 0.0599
Schistosoma mansoni hypothetical protein 0.0293 0.0833 0.1001
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.065 0.0642
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0098 0.009
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0034 0.0047 0.0047
Echinococcus multilocularis transient receptor potential ion channel A 0.0098 0.0242 0.0235
Loa Loa (eye worm) hypothetical protein 0.1241 0.3718 0.4461
Loa Loa (eye worm) hypothetical protein 0.0041 0.0066 0.007
Echinococcus multilocularis ecdysone induced protein 78C 0.0051 0.0098 0.009
Schistosoma mansoni smad1 5 8 and 0.0033 0.0044 0.0052
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0083 0.0196 0.0226
Mycobacterium leprae Probable 6-phosphogluconolactonase DevB (6PGL) 0.0034 0.0047 0.0543
Brugia malayi hypothetical protein 0.0454 0.1325 0.1583
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0025 0.003
Plasmodium vivax ataxin-2 like protein, putative 0.0185 0.0506 0.0591
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0029 0.0031 0.0023
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0062 0.0054
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.013 0.0338 0.1127
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0163 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0051 0.0098 0.0108
Trypanosoma cruzi ISWI complex protein 0.0031 0.0036 0.0034
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0925 0.2757 0.3305
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0029 0.0031 0.0043
Loa Loa (eye worm) hypothetical protein 0.0098 0.0242 0.0281
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0098 0.0242 0.0255
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.006 0.0125 0.0141
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0047 0.0039
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0051 0.0098 0.0117
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0083 0.0196 0.0188
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.279 0.8429 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0098 0.0242 0.1081
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0478 0.0558
Schistosoma mansoni microtubule-associated protein tau 0.0678 0.2005 0.2409
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0029 0.0031 0.0043
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0062 0.0065
Loa Loa (eye worm) hypothetical protein 0.0032 0.004 0.0038
Mycobacterium ulcerans beta-lactamase 0.0039 0.0062 0.0038
Entamoeba histolytica hypothetical protein 0.0209 0.0577 0.263
Echinococcus granulosus chromobox protein 1 0.0072 0.0163 0.0186
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0422 0.1226 0.1465
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0016 0.0019
Schistosoma mansoni smad1 5 8 and 0.0033 0.0044 0.0052
Schistosoma mansoni transient receptor potential channel 0.0067 0.0148 0.0178
Schistosoma mansoni glucosamine-6-phosphate isomerase 0.0034 0.0047 0.0057
Leishmania major glucosamine-6-phosphate isomerase, putative 0.0034 0.0047 0.0047
Echinococcus granulosus histone lysine methyltransferase setb 0.0067 0.0147 0.0167
Schistosoma mansoni zinc finger protein 0.0031 0.0036 0.0043
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0044 0.0043
Brugia malayi hypothetical protein 0.0027 0.0025 0.002
Schistosoma mansoni ap endonuclease 0.006 0.0125 0.015
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0028
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.001
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0051 0.0098 0.0108
Loa Loa (eye worm) hypothetical protein 0.0454 0.1325 0.1583
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0758 0.089
Loa Loa (eye worm) hypothetical protein 0.0081 0.0191 0.022
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.006 0.0125 0.0141
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0015 0.0008
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0029 0.0031 0.0027
Brugia malayi ecdysteroid receptor 0.0051 0.0098 0.0108
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0098 0.0108
Toxoplasma gondii propionate-CoA ligase 0.0029 0.0031 0.0027
Onchocerca volvulus 0.0051 0.0098 0.0626
Echinococcus granulosus smad 0.0033 0.0044 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0051 0.0098 0.0108
Schistosoma mansoni retinoic acid receptor RXR 0.0051 0.0098 0.0117
Schistosoma mansoni jumonji domain containing protein 0.0082 0.0193 0.0231
Schistosoma mansoni tar DNA-binding protein 0.0201 0.0554 0.0665
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.0069 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0201 0.0554 0.0665
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0029 0.0031 0.0027
Brugia malayi Smad1 0.0033 0.0044 0.0043
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0016 0.0008
Plasmodium vivax SET domain protein, putative 0.0033 0.0043 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0051 0.0098 0.0108
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0478 0.0558
Leishmania major hypothetical protein, conserved 0.0031 0.0036 0.0034
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0016 0.0008
Entamoeba histolytica hypothetical protein 0.0024 0.0015 0.0031
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0034 0.0047 0.0047
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0154 0.0479
Schistosoma mansoni hypothetical protein 0.0047 0.0087 0.0105
Plasmodium vivax basic transcription factor 3b, putative 0.0216 0.0599 0.0701
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0551 0.1619 0.1937
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0083 0.0196 0.0188
Schistosoma mansoni hypothetical protein 0.0031 0.0036 0.0043
Toxoplasma gondii isocitrate dehydrogenase 0.0083 0.0196 0.0223
Trypanosoma cruzi transcription factor btf3, putative 0.0216 0.0599 0.071
Toxoplasma gondii ABC1 family protein 0.0039 0.0062 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0051 0.0098 0.0108
Brugia malayi MH1 domain containing protein 0.0033 0.0044 0.0043
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0083 0.0196 0.0226
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0422 0.1226 0.1465
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0049 0.0093 0.0103
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0034 0.0047 0.0047
Mycobacterium ulcerans acyl-CoA synthetase 0.0098 0.0242 0.0255
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.002
Echinococcus granulosus sodium:myo inositol cotransporter 0.0039 0.006 0.0063
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0506 0.0592
Onchocerca volvulus 0.0098 0.0242 0.1727
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.006 0.0125 0.0117
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.017 0.0204
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0083 0.0196 0.0188
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.18 0.5417 0.6494
Schistosoma mansoni inositol transporter 0.0039 0.006 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0098 0.0108
Echinococcus multilocularis FTZ F1 alpha 0.0051 0.0098 0.009
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0083 0.0196 0.0223
Echinococcus multilocularis chromobox protein 1 0.0072 0.0163 0.0155
Plasmodium falciparum ataxin-2 like protein, putative 0.0185 0.0506 0.0591
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0154 0.0479
Loa Loa (eye worm) hypothetical protein 0.0051 0.0098 0.0108
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.2755 0.8325 1
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0076 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0201 0.0554 0.0665
Schistosoma mansoni importin beta-1 0.0029 0.0031 0.0038
Trichomonas vaginalis esterase, putative 0.0039 0.0062 0.0065
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0065
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0044 0.0043
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.006 0.0125 0.0139
Trypanosoma brucei ISWI complex protein 0.0031 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.0232 0.065 0.0772
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0039 0.0037
Schistosoma mansoni ran 0.0021 0.0008 0.001
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.006 0.0125 0.0141
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.002
Giardia lamblia DNA repair protein RAD52 0.0733 0.2172 0.257
Mycobacterium tuberculosis Conserved protein 0.0039 0.0062 0.0154
Schistosoma mansoni cpg binding protein 0.0029 0.0032 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0051 0.0098 0.0108
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.017 0.0194
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0083 0.0196 0.0236
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0758 0.089
Echinococcus multilocularis snurportin 1 0.031 0.0885 0.0878
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0083 0.0196 0.0627
Schistosoma mansoni hypothetical protein 0.0632 0.1866 0.2242
Echinococcus multilocularis thyroid hormone receptor alpha 0.0051 0.0098 0.009
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0029 0.0031 0.0027
Brugia malayi latrophilin 2 splice variant baaae 0.0632 0.1866 0.2235
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0163 0.0186
Schistosoma mansoni transient receptor potential channel 0.0067 0.0148 0.0178
Schistosoma mansoni inositol transporter 0.0039 0.006 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0051 0.0098 0.0108
Mycobacterium tuberculosis Conserved protein 0.0039 0.0062 0.0154
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0268 0.0758 0.0902
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0027
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.2755 0.8325 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0051 0.0098 0.0117
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0047 0.0047
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0478 0.0558
Trypanosoma cruzi PAB1-binding protein , putative 0.0185 0.0506 0.0599
Brugia malayi PHD-finger family protein 0.0051 0.01 0.011
Brugia malayi hypothetical protein 0.0185 0.0506 0.0599
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0125 0.0139
Brugia malayi AMP-binding enzyme family protein 0.0098 0.0242 0.0281
Brugia malayi jmjC domain containing protein 0.0044 0.0076 0.0082
Schistosoma mansoni tar DNA-binding protein 0.0201 0.0554 0.0665
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0031 0.0027
Echinococcus granulosus FTZ F1 alpha 0.0051 0.0098 0.0108
Trichomonas vaginalis set domain proteins, putative 0.0257 0.0724 0.0851
Schistosoma mansoni smad 0.0033 0.0044 0.0052
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0051 0.0098 0.0117
Schistosoma mansoni hypothetical protein 0.0032 0.0039 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0051 0.0098 0.0108
Plasmodium vivax acyl-CoA synthetase, putative 0.0073 0.0166 0.0188
Echinococcus granulosus lysine specific demethylase 5A 0.0044 0.0076 0.0082
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.002
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0076 0.0091
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0422 0.1226 0.1465
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0076 0.008
Echinococcus granulosus 6 phosphogluconolactonase 0.0034 0.0047 0.0047
Echinococcus granulosus sodium:glucose cotransporter 2 0.0039 0.006 0.0063
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0065
Entamoeba histolytica acyl-CoA synthetase, putative 0.0098 0.0242 0.1081
Brugia malayi Muscleblind-like protein 0.1241 0.3718 0.4461
Onchocerca volvulus 0.0029 0.0032 0.0121
Onchocerca volvulus Alhambra homolog 0.0032 0.0039 0.0175
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0083 0.0196 0.0226
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0076 0.0091
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.001
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0049 0.0093 0.0103
Brugia malayi Isocitrate dehydrogenase 0.0083 0.0196 0.0226
Brugia malayi RNA binding protein 0.0201 0.0554 0.0656
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0098 0.0242 0.0281
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0039 0.0037
Loa Loa (eye worm) hypothetical protein 0.0051 0.0098 0.0108
Entamoeba histolytica protein kinase domain containing protein 0.0049 0.0093 0.0395
Brugia malayi steroid hormone receptor 0.0051 0.0098 0.0108
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0031 0.0043
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0062 0.1027
Schistosoma mansoni hypothetical protein 0.0041 0.0068 0.0082
Loa Loa (eye worm) hypothetical protein 0.0064 0.0138 0.0156
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.027 0.0765 0.0886
Schistosoma mansoni transcription factor btf3 0.0216 0.0599 0.0719
Onchocerca volvulus Bile acid receptor homolog 0.0051 0.0098 0.0625
Trypanosoma cruzi PAB1-binding protein , putative 0.0185 0.0506 0.0599
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0162 0.0185
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0016 0.001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0051 0.0098 0.0108
Brugia malayi Latrophilin receptor protein 2 0.0293 0.0833 0.0992
Loa Loa (eye worm) hypothetical protein 0.0067 0.0147 0.0167
Schistosoma mansoni RAR-like nuclear receptor 0.0051 0.0098 0.0117
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0913 0.272 0.3261
Brugia malayi Calcitonin receptor-like protein seb-1 0.0925 0.2757 0.3305
Trypanosoma cruzi transcription factor btf3, putative 0.0216 0.0599 0.071
Brugia malayi Pre-SET motif family protein 0.0226 0.063 0.0748
Entamoeba histolytica hypothetical protein 0.0075 0.017 0.0747
Onchocerca volvulus Protein ultraspiracle homolog 0.0051 0.0098 0.0625
Echinococcus multilocularis muscleblind protein 1 0.1241 0.3718 0.3713
Entamoeba histolytica exodeoxyribonuclease III, putative 0.006 0.0125 0.0541
Brugia malayi TAR-binding protein 0.0201 0.0554 0.0656
Echinococcus granulosus importin subunit beta 1 0.0029 0.0031 0.0028
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0043 0.0035
Leishmania major basic transcription factor 3a, putative 0.0216 0.0599 0.071
Echinococcus multilocularis short transient receptor potential channel 6 0.0067 0.0148 0.014
Mycobacterium ulcerans lipoprotein LpqF 0.013 0.0338 0.037
Echinococcus multilocularis transient receptor potential gamma protein 0.0102 0.0253 0.0245
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0098 0.0242 0.0255
Schistosoma mansoni transient receptor potential channel 4 0.0102 0.0253 0.0304
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.035 0.1008 0.1203
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0098 0.0118
Loa Loa (eye worm) TAR-binding protein 0.0201 0.0554 0.0656
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0016 0.001
Mycobacterium leprae Probable lipase LipE 0.0039 0.0062 0.1027
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0066 0.0069
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0062 0.0154
Echinococcus granulosus transient receptor potential ion channel A 0.0098 0.0242 0.0282
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0051 0.0098 0.0108
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0062 0.0065
Loa Loa (eye worm) hypothetical protein 0.0041 0.0069 0.0073
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0121 0.0311 0.0365
Loa Loa (eye worm) hypothetical protein 0.0038 0.0058 0.006
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.006 0.0125 0.0141
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0073 0.0166 0.019
Echinococcus granulosus zinc finger protein 0.0041 0.0067 0.0071
Schistosoma mansoni ap endonuclease 0.006 0.0125 0.015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0422 0.1226 0.1473
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0025 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0062 0.0065
Trypanosoma brucei glucosamine-6-phosphate isomerase, putative 0.0034 0.0047 0.0047
Schistosoma mansoni nuclear receptor 0.0024 0.0016 0.0019
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0039 0.0031
Entamoeba histolytica protein kinase, putative 0.0049 0.0093 0.0395
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0062 0.0065
Brugia malayi beta-lactamase family protein 0.0039 0.0062 0.0065
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.0085 0.0102
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0031 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.003 0.0026
Echinococcus multilocularis geminin 0.1908 0.5746 0.5743
Leishmania major 4-coumarate:coa ligase-like protein 0.0098 0.0242 0.0281
Mycobacterium ulcerans 6-phosphogluconolactonase 0.0034 0.0047 0.002
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0016 0.001
Mycobacterium ulcerans hypothetical protein 0.0039 0.0062 0.0038
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0016 0.001
Loa Loa (eye worm) RNA binding protein 0.0201 0.0554 0.0656
Echinococcus multilocularis smad 0.0033 0.0044 0.0036
Echinococcus multilocularis short transient receptor potential channel 6 0.0067 0.0148 0.014
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0083 0.0196 0.0188
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0062 0.0065
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0062 0.0154
Brugia malayi hypothetical protein 0.0232 0.065 0.0772
Echinococcus granulosus tar DNA binding protein 0.0201 0.0554 0.0656
Loa Loa (eye worm) hypothetical protein 0.0039 0.0062 0.0065
Schistosoma mansoni hypothetical protein 0.1908 0.5746 0.6902
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0016 0.0019
Onchocerca volvulus 0.0029 0.0031 0.0113
Loa Loa (eye worm) hypothetical protein 0.0073 0.0166 0.019
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0044 0.0036
Loa Loa (eye worm) hypothetical protein 0.0051 0.0098 0.0108
Schistosoma mansoni hypothetical protein 0.1908 0.5746 0.6902
Onchocerca volvulus 0.0039 0.0062 0.0354
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0047 0.0056
Entamoeba histolytica protein kinase domain containing protein 0.0049 0.0093 0.0395
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0039 0.006 0.0063
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0044 0.0052
Onchocerca volvulus 0.0454 0.1325 1
Leishmania major hypothetical protein, conserved 0.0039 0.0062 0.0065
Schistosoma mansoni sodium/solute symporter 0.0039 0.006 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0098 0.0108
Leishmania major 4-coumarate:coa ligase-like protein 0.0098 0.0242 0.0281
Trypanosoma cruzi ISWI complex protein 0.0031 0.0036 0.0034
Schistosoma mansoni ran 0.0021 0.0008 0.001
Plasmodium vivax acetyl-CoA synthetase, putative 0.0029 0.0031 0.0027
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.002
Brugia malayi Importin beta-1 subunit 0.0029 0.0031 0.0028
Plasmodium falciparum ataxin-2 like protein, putative 0.0185 0.0506 0.0591
Entamoeba histolytica hypothetical protein 0.0075 0.017 0.0747
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0051 0.0098 0.0108
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0034 0.0047 0.0047
Echinococcus granulosus TRP transient receptor potential channel 0.0038 0.0058 0.006
Loa Loa (eye worm) Smad1 0.0033 0.0044 0.0043
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0093 0.0102
Trypanosoma brucei beta lactamase 0.013 0.0338 0.0397
Echinococcus granulosus short transient receptor potential channel 6 0.0067 0.0148 0.0168
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0051 0.0098 0.009
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0025 0.002
Brugia malayi Bromodomain containing protein 0.0036 0.0053 0.0055
Echinococcus granulosus peregrin 0.0036 0.0053 0.0055
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.013 0.0338 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0043 0.0052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0098 0.0108
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0016 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.0486 0.142 0.1698
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.001
Schistosoma mansoni nuclear hormone receptor 0.0051 0.0098 0.0117
Brugia malayi PHD-finger family protein 0.0032 0.0039 0.0037
Brugia malayi intracellular kinase 0.0049 0.0093 0.0103
Onchocerca volvulus 0.0039 0.0062 0.0354
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.001
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0073 0.0166 0.0144
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.001
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.2755 0.8325 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0422 0.1226 0.1465
Onchocerca volvulus 0.0045 0.0079 0.0483
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0062 0.0065
Plasmodium falciparum phd finger protein, putative 0.0032 0.0039 0.0037
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.279 0.8429 1
Schistosoma mansoni cpg binding protein 0.0035 0.0049 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0051 0.0098 0.0108
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0031 0.0023
Schistosoma mansoni zinc finger protein 0.0024 0.0016 0.0019
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0141 0.016
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0016 0.0019
Brugia malayi nuclear receptor NHR-67 0.0024 0.0016 0.001
Mycobacterium ulcerans lipase LipD 0.0039 0.0062 0.0038
Loa Loa (eye worm) hypothetical protein 0.0548 0.1611 0.1927
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0049 0.0093 0.0103
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.001
Echinococcus granulosus muscleblind protein 0.1241 0.3718 0.4461
Echinococcus multilocularis peregrin 0.0036 0.0053 0.0045
Plasmodium vivax importin-beta 2, putative 0.0029 0.0031 0.0028
Onchocerca volvulus 0.0029 0.0031 0.0113
Leishmania major hypothetical protein, conserved 0.0185 0.0506 0.0599
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0062 0.0065
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0031 0.0027
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0016 0.001
Echinococcus granulosus transient receptor potential gamma protein 0.0102 0.0253 0.0294
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.001
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0062 0.0154
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0039 0.006 0.0062
Brugia malayi hypothetical protein 0.0119 0.0306 0.0359
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0062 0.0154
Loa Loa (eye worm) hypothetical protein 0.0141 0.0373 0.0439
Schistosoma mansoni acetyl-CoA synthetase 0.0029 0.0031 0.0037
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0051 0.0098 0.009
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0032 0.0029
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.0166 0.0163
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0925 0.2757 0.3305
Brugia malayi RNA recognition motif domain containing protein 0.0201 0.0554 0.0656
Echinococcus granulosus microtubule associated protein 2 0.0678 0.2005 0.2402
Plasmodium falciparum acyl-CoA synthetase 0.0073 0.0166 0.0188
Brugia malayi photoreceptor-specific nuclear receptor 0.0051 0.0098 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0066 0.0069
Loa Loa (eye worm) hypothetical protein 0.0073 0.0166 0.019
Brugia malayi Sodium:solute symporter family protein 0.0039 0.006 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0079 0.0095
Loa Loa (eye worm) hypothetical protein 0.0051 0.0098 0.0108
Onchocerca volvulus 0.0257 0.0724 0.5413
Loa Loa (eye worm) oxidoreductase 0.0029 0.0031 0.0027
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0062 0.0075

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 25 mg kg-1 Ability to inhibit the accumulation of inflammatory cytokine interleukin-1 alpha (IL-1 alpha) in the serum of C. parvum-primed mice by po administration ChEMBL. No reference
ED50 (functional) > 25 mg kg-1 Ability to inhibit the accumulation of cytokine interleukin-6 (IL-6) in the serum of C. parvum-primed mice by po administration ChEMBL. No reference
ED50 (functional) > 25 mg kg-1 Ability to inhibit the accumulation of tumor necrosis factor-alpha (TNF-alpha) in the serum of C. parvum-primed mice by po administration ChEMBL. No reference
ED50 (functional) > 25 mg kg-1 Ability to inhibit the accumulation of gamma-interferon (gamma-IFN) in the serum of C. parvum-primed mice by po administration ChEMBL. No reference
ED50 (functional) > 25 mg kg-1 Ability to inhibit the accumulation of inflammatory cytokine interleukin-1 alpha (IL-1 alpha) in the serum of C. parvum-primed mice by po administration ChEMBL. No reference
ED50 (functional) > 25 mg kg-1 Ability to inhibit the accumulation of cytokine interleukin-6 (IL-6) in the serum of C. parvum-primed mice by po administration ChEMBL. No reference
ED50 (functional) > 25 mg kg-1 Ability to inhibit the accumulation of tumor necrosis factor-alpha (TNF-alpha) in the serum of C. parvum-primed mice by po administration ChEMBL. No reference
ED50 (functional) > 25 mg kg-1 Ability to inhibit the accumulation of gamma-interferon (gamma-IFN) in the serum of C. parvum-primed mice by po administration ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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