Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.0663 | 0.0663 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0337 | 1 |
Onchocerca volvulus | 0.0518 | 1 | 1 | |
Brugia malayi | mbt repeat family protein | 0.0051 | 0.0516 | 0.0516 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0516 | 0.0516 |
Schistosoma mansoni | glutaminase | 0.0317 | 0.5921 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0051 | 0.0516 | 0.0516 | |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0051 | 0.0516 | 0.0516 |
Schistosoma mansoni | hypothetical protein | 0.0307 | 0.5724 | 0.965 |
Loa Loa (eye worm) | hypothetical protein | 0.0518 | 1 | 1 |
Echinococcus multilocularis | Protein lozenge | 0.0065 | 0.0809 | 0.1376 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0051 | 0.0516 | 0.0522 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0658 | 0.0658 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0337 | 1 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0051 | 0.0516 | 0.0516 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0211 | 0.3767 | 0.6173 |
Schistosoma mansoni | tar DNA-binding protein | 0.0211 | 0.3767 | 0.6173 |
Loa Loa (eye worm) | runx1 | 0.0065 | 0.0809 | 0.0809 |
Schistosoma mansoni | tar DNA-binding protein | 0.0211 | 0.3767 | 0.6173 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0211 | 0.3767 | 0.3767 |
Schistosoma mansoni | lozenge | 0.0065 | 0.0809 | 0.0918 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0058 | 0.0658 | 0.065 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0337 | 0.0079 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0058 | 0.0658 | 0.0936 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0337 | 0.0079 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0051 | 0.0516 | 0.0398 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0058 | 0.0658 | 0.0936 |
Brugia malayi | TAR-binding protein | 0.0211 | 0.3767 | 0.3767 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0337 | 1 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0051 | 0.0516 | 0.0522 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0199 | 0.3531 | 0.9312 |
Echinococcus granulosus | tar DNA binding protein | 0.0211 | 0.3767 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0051 | 0.0516 | 0.0398 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0051 | 0.0516 | 0.0522 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0051 | 0.0516 | 0.0522 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0663 | 0.0663 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0058 | 0.0658 | 0.0936 |
Schistosoma mansoni | tar DNA-binding protein | 0.0211 | 0.3767 | 0.6173 |
Loa Loa (eye worm) | glutaminase | 0.0317 | 0.5921 | 0.5921 |
Mycobacterium ulcerans | glutaminase | 0.0317 | 0.5921 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0317 | 0.5921 | 0.5921 |
Brugia malayi | glutaminase DH11.1 | 0.0317 | 0.5921 | 0.5921 |
Trichomonas vaginalis | glutaminase, putative | 0.0317 | 0.5921 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0337 | 1 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0058 | 0.0658 | 0.0658 |
Loa Loa (eye worm) | RNA binding protein | 0.0211 | 0.3767 | 0.3767 |
Schistosoma mansoni | tar DNA-binding protein | 0.0211 | 0.3767 | 0.6173 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0051 | 0.0516 | 0.0398 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0337 | 0.0337 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.0663 | 0.0663 |
Loa Loa (eye worm) | hypothetical protein | 0.0518 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.0663 | 0.0663 |
Echinococcus multilocularis | tar DNA binding protein | 0.0211 | 0.3767 | 1 |
Brugia malayi | mbt repeat family protein | 0.0051 | 0.0516 | 0.0516 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0058 | 0.0658 | 0.0936 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0211 | 0.3767 | 0.3767 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0211 | 0.3767 | 0.3767 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0211 | 0.3767 | 0.3767 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | MBCTL1 | 0.0058 | 0.0658 | 0.0658 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0199 | 0.3531 | 0.9312 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.