Detailed information for compound 1534398

Basic information

Technical information
  • TDR Targets ID: 1534398
  • Name: 3-(4-propan-2-yloxyphenyl)pyrrolidine-2,5-dio ne
  • MW: 233.263 | Formula: C13H15NO3
  • H donors: 1 H acceptors: 2 LogP: 1.43 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Oc1ccc(cc1)C1CC(=O)NC1=O)C
  • InChi: 1S/C13H15NO3/c1-8(2)17-10-5-3-9(4-6-10)11-7-12(15)14-13(11)16/h3-6,8,11H,7H2,1-2H3,(H,14,15,16)
  • InChiKey: HKLLMIGGBZSJIG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-isopropoxyphenyl)pyrrolidine-2,5-dione
  • 3-(4-isopropoxyphenyl)pyrrolidine-2,5-quinone
  • 27950-88-5
  • 3-(4-Isopropoxy-phenyl)-pyrrolidine-2,5-dione
  • BAS 00404226
  • 2,5-Pyrrolidinedione, 3-(4-(1-methylethoxy)phenyl)- (9CI)
  • 2-(p-Isopropoxyphenyl)succinimide
  • 3-(4-(1-Methylethoxy)phenyl)-2,5-pyrrolidinedione
  • Oprea1_735341
  • Pufemid
  • Pufemide
  • Succinimide, 2-(p-isopropoxyphenyl)-
  • BRN 1465355
  • Oprea1_193003

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ferrodoxin reductase-like protein 0.0055 0.0315 0.0883
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0247 0.0708
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0055 0.0315 0.0925
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0199 0.056
Brugia malayi isocitrate dehydrogenase 0.0017 0.0063 0.0148
Brugia malayi AMP-binding enzyme family protein 0.005 0.0283 0.0853
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0283 0.2057
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0055 0.0315 0.0517
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0063 0.0059
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0055 0.0315 0.0883
Onchocerca volvulus 0.0033 0.0171 0.2126
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0018 0.0014
Schistosoma mansoni hypothetical protein 0.0018 0.0071 0.0067
Trypanosoma brucei trypanothione reductase 0.0478 0.3129 1
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0103 0.0098
Loa Loa (eye worm) hypothetical protein 0.0037 0.0199 0.058
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0063 0.0125
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0247 0.0665
Trichomonas vaginalis DNA polymerase eta, putative 0.0045 0.0247 0.1933
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.035 0.2278 0.7254
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0048 0.0044
Schistosoma mansoni terminal deoxycytidyl transferase 0.0045 0.0247 0.0243
Trypanosoma cruzi trypanothione reductase, putative 0.0155 0.098 0.3069
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0063 0.0059
Echinococcus multilocularis dna polymerase eta 0.0074 0.0444 0.0439
Mycobacterium tuberculosis Probable dehydrogenase 0.0691 0.455 0.8717
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0055 0.0315 0.0953
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0247 0.0665
Brugia malayi serine/threonine-protein kinase plk-2 0.0102 0.0629 0.1965
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0048 0.0094
Loa Loa (eye worm) glutathione reductase 0.0478 0.3129 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0048 0.0372
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0155 0.098 0.3076
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0048 0.0064
Toxoplasma gondii NADPH-glutathione reductase 0.0155 0.098 0.3076
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0055 0.0315 0.0934
Schistosoma mansoni microtubule-associated protein tau 0.1509 1 1
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0055 0.0315 0.0925
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0174 0.1108 0.1104
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.0048 0.0074
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0048 0.0026
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0048 0.0064
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0015 0.0048 0.0044
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0023 0.0103 0.0098
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0071 0.0067
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0103 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0247 0.0665
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0155 0.098 0.3069
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0171 0.0491
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0055 0.0315 0.0883
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0103 0.0196
Leishmania major trypanothione reductase 0.0478 0.3129 1
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0103 0.0802
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.1052 0.3301
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0063 0.0069
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.02 0.1279 1
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0055 0.0315 0.246
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0042 0.0047
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0334 0.1017
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0055 0.0315 0.2311
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0048 0.0097
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0277 0.0804
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0103 0.0196
Treponema pallidum NADH oxidase 0.0155 0.098 0.7605
Giardia lamblia Kinase, PLK 0.0102 0.0629 0.4743
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0048 0.0097
Onchocerca volvulus 0.005 0.0283 0.4046
Trypanosoma brucei DNA polymerase eta, putative 0.0074 0.0444 0.1301
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0155 0.098 0.3037
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0055 0.0315 0.0542
Entamoeba histolytica deoxycytidyl transferase, putative 0.0045 0.0247 0.1774
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0629 0.4917
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0155 0.098 0.3076
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0103 0.0251
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0055 0.0315 0.0542
Trichomonas vaginalis disulfide oxidoreductase, putative 0.02 0.1279 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0048 0.0097
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0055 0.0315 0.031
Echinococcus granulosus intestinal type alkaline phosphatase 0.0174 0.1108 0.1104
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0094
Trypanosoma brucei polo-like protein kinase 0.0102 0.0629 0.1901
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0048 0.0026
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0048 0.0026
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0263 0.0259
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0155 0.098 0.3069
Chlamydia trachomatis thioredoxin reductase 0.02 0.1279 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0691 0.455 0.8717
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0283 0.048
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0063 0.0069
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0283 0.048
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0055 0.0315 0.0934
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0023 0.0103 0.0196
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0315 0.0925
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0155 0.098 0.3037
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0155 0.098 0.7577
Echinococcus granulosus bloom syndrome protein 0.0023 0.0103 0.0098
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0103 0.0802
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0055 0.0315 0.0883
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0165 0.1052 0.327
Trichomonas vaginalis disulfide oxidoreductase, putative 0.02 0.1279 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0263 0.0788
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0055 0.0315 0.031
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0334 0.1015
Toxoplasma gondii propionate-CoA ligase 0.0015 0.0048 0.0074
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0048 0.0097
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0247 0.0665
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0055 0.0315 0.2203
Giardia lamblia DINP protein human, muc B family 0.0045 0.0247 0.1658
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0055 0.0315 0.246
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0015 0.0048 0.0044
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0048 0.0044
Echinococcus multilocularis dna polymerase kappa 0.0045 0.0247 0.0243
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0691 0.455 0.8717
Echinococcus granulosus cpg binding protein 0.0035 0.0184 0.0179
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0155 0.098 0.3092
Schistosoma mansoni hypothetical protein 0.0039 0.0213 0.0208
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0055 0.0315 0.031
Schistosoma mansoni glutamate synthase 0.0055 0.0315 0.031
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0048 0.0044
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0028 0.001
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.01 0.0615 0.1919
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0334 0.1017
Schistosoma mansoni alkaline phosphatase 0.0174 0.1108 0.1104
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0283 0.078
Schistosoma mansoni cpg binding protein 0.0035 0.0184 0.0179
Leishmania major DNA polymerase kappa, putative 0.0045 0.0247 0.0665
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0055 0.0315 0.0517
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0048 0.0026
Loa Loa (eye worm) hypothetical protein 0.0018 0.0071 0.0171
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0691 0.455 0.8717
Loa Loa (eye worm) hypothetical protein 0.0055 0.0315 0.0953
Trichomonas vaginalis disulfide oxidoreductase, putative 0.02 0.1279 1
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0055 0.0315 0.0934
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0791 0.5215 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0478 0.3129 0.5975
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0055 0.0315 0.2311
Toxoplasma gondii selenide, water dikinase 0.0055 0.0315 0.0934
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0247 0.0665
Schistosoma mansoni glutamate synthase 0.0055 0.0315 0.031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0155 0.098 0.3069
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0174 0.1108 0.1104
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0048 0.0026
Loa Loa (eye worm) RecQ helicase 0.0023 0.0103 0.0271
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0155 0.098 0.7577
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0263 0.0259
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0277 0.0804
Schistosoma mansoni hypothetical protein 0.0055 0.0315 0.031
Echinococcus granulosus thioredoxin glutathione reductase 0.0479 0.3138 0.3135
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0063 0.0059
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.02 0.1279 0.2384
Giardia lamblia NADH oxidase lateral transfer candidate 0.0155 0.098 0.7577
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0286 0.2236
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0063 0.0115
Trypanosoma brucei unspecified product 0.0031 0.0155 0.0365
Mycobacterium tuberculosis Conserved hypothetical protein 0.0184 0.1176 0.2204
Leishmania major hypothetical protein, conserved 0.0055 0.0315 0.0883
Brugia malayi CXXC zinc finger family protein 0.0033 0.0171 0.0494
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0055 0.0315 0.2203
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0247 0.0708
Leishmania major DNA polymerase eta, putative 0.0043 0.0239 0.0636
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0055 0.0315 0.0934
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0155 0.098 0.3037
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0155 0.0365
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0048 0.0074
Brugia malayi Thioredoxin reductase 0.0478 0.3129 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0055 0.0315 0.2203
Echinococcus granulosus dnaJ subfamily B 0.0474 0.3103 0.3099
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0155 0.0365
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0055 0.0315 0.2203
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0055 0.0315 0.246
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0048 0.0044
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0055 0.0315 0.031
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0283 0.1945
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0283 0.0455
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0185 0.0292
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0283 0.1945
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0025 0.002
Mycobacterium ulcerans acetyl-CoA synthetase 0.0015 0.0048 0.0044
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0283 0.078
Mycobacterium tuberculosis Conserved hypothetical protein 0.0045 0.0247 0.0412
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0247 0.1658
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0055 0.0315 0.0955
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.035 0.2278 0.7254
Trichomonas vaginalis glutamate synthase, putative 0.0055 0.0315 0.246
Mycobacterium ulcerans monoxygenase 0.0055 0.0315 0.2203
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0185 0.0292
Loa Loa (eye worm) hypothetical protein 0.0023 0.0103 0.0271
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0018 0.0014
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0055 0.0315 0.0925
Trypanosoma brucei mitochondrial DNA polymerase beta 0.035 0.2278 0.7241
Trypanosoma cruzi polo-like protein kinase, putative 0.0102 0.0629 0.1939
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0247 0.0665
Loa Loa (eye worm) hypothetical protein 0.0037 0.0199 0.058
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0063 0.0125
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0071 0.0067
Entamoeba histolytica serine/threonine protein kinase, putative 0.0102 0.0629 0.4816
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0055 0.0315 0.0517
Treponema pallidum thioredoxin reductase (trxB) 0.02 0.1279 1
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0629 0.4917
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0247 0.0665
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0155 0.0365
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0048 0.0018
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0199 0.0507
Trypanosoma cruzi NADH dehydrogenase, putative 0.0055 0.0315 0.0925
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0155 0.098 0.0975
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0247 0.0708
Loa Loa (eye worm) hypothetical protein 0.0037 0.0199 0.058
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0155 0.098 0.6893
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0155 0.098 0.3037
Echinococcus granulosus dna polymerase kappa 0.0045 0.0247 0.0243
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0055 0.0315 0.0542
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0174 0.1108 0.1104
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0055 0.0315 0.0934
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0103 0.0274
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0048 0.0026
Schistosoma mansoni DNA polymerase eta 0.0074 0.0444 0.0439
Trypanosoma cruzi DNA polymerase eta, putative 0.0074 0.0444 0.1341
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0015 0.0048 0.0044
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0055 0.0315 0.031
Schistosoma mansoni sulfide quinone reductase 0.0055 0.0315 0.031
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0629 0.4917
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0045 0.0247 0.0243
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0055 0.0315 0.0934
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0023 0.0103 0.0098
Trypanosoma brucei unspecified product 0.0031 0.0155 0.0365
Trichomonas vaginalis disulfide oxidoreductase, putative 0.02 0.1279 1
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0629 0.4917
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0185 0.0292
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0283 0.1945
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0015 0.0048 0.0044
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0055 0.0315 0.0925
Leishmania major hypothetical protein, conserved 0.0055 0.0315 0.0883
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.02 0.1279 0.2404
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0103 0.0621
Schistosoma mansoni cpg binding protein 0.0033 0.0171 0.0166
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0283 0.1945
Plasmodium falciparum thioredoxin reductase 0.0478 0.3129 1
Schistosoma mansoni cpg binding protein 0.0035 0.0184 0.0179
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0055 0.0315 0.0934
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0055 0.0315 0.2311
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0691 0.455 0.8717
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0155 0.098 0.3069
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0071 0.0067
Echinococcus multilocularis alkaline phosphatase 0.0174 0.1108 0.1104
Leishmania major hypothetical protein, conserved 0.0055 0.0315 0.0883
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0063 0.0059
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0063 0.0057
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0028 0.001
Schistosoma mansoni sulfide quinone reductase 0.0055 0.0315 0.031
Plasmodium falciparum thioredoxin reductase 0.0155 0.098 0.3037
Schistosoma mansoni kinase 0.0052 0.0295 0.029
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0199 0.1265
Mycobacterium ulcerans hypothetical protein 0.0055 0.0315 0.2203
Giardia lamblia Thioredoxin reductase 0.02 0.1279 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0263 0.079
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0055 0.0315 0.031
Loa Loa (eye worm) hypothetical protein 0.0037 0.0199 0.058
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0055 0.0315 0.0883
Plasmodium vivax DNA repair protein REV1, putative 0.0014 0.0042 0.0056
Mycobacterium tuberculosis Probable oxidoreductase 0.0791 0.5215 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0048 0.0026
Toxoplasma gondii thioredoxin reductase 0.0478 0.3129 1
Echinococcus multilocularis GPCR, family 2 0.0018 0.0071 0.0067
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0283 0.078
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0048 0.0044
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0042 0.0047
Mycobacterium ulcerans hypothetical protein 0.0184 0.1176 0.9164
Brugia malayi AMP-binding enzyme family protein 0.005 0.0283 0.0853
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0048 0.0026
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0155 0.098 0.7226
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0063 0.0145
Mycobacterium ulcerans ferredoxin reductase 0.0055 0.0315 0.2203
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0055 0.0315 0.0955
Echinococcus granulosus GPCR family 2 0.0018 0.0071 0.0067
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0155 0.098 0.3037
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0055 0.0315 0.246
Echinococcus multilocularis thioredoxin glutathione reductase 0.0479 0.3138 0.3135
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0015 0.0048 0.0044
Loa Loa (eye worm) hypothetical protein 0.0074 0.0444 0.1367
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0103 0.0274
Toxoplasma gondii hypothetical protein 0.0056 0.0325 0.0968
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0077
Trypanosoma brucei NADH dehydrogenase 0.0055 0.0315 0.0883
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0103 0.0274
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0174 0.1108 0.1104
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0045 0.0247 0.0412
Mycobacterium ulcerans NADH dehydrogenase 0.0055 0.0315 0.2203
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0048 0.0372
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0048 0.0018
Schistosoma mansoni DNA helicase recq5 0.0023 0.0103 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0263 0.0259
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0055 0.0315 0.031
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0048 0.0044
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0286 0.2236
Schistosoma mansoni DNA helicase recq1 0.0023 0.0103 0.0098
Loa Loa (eye worm) hypothetical protein 0.0058 0.0334 0.1015
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0155 0.098 0.6893
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0055 0.0315 0.2203
Loa Loa (eye worm) hypothetical protein 0.005 0.0283 0.085
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.0048 0.0018
Loa Loa (eye worm) programmed cell death 8 0.0055 0.0315 0.0953
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0042 0.0047
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0055 0.0315 0.2203
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0063 0.0059
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0155 0.098 0.3037
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0155 0.098 0.3069
Loa Loa (eye worm) hypothetical protein 0.0039 0.0213 0.0624
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0028 0.0023
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0155 0.098 0.1825
Trypanosoma brucei unspecified product 0.0045 0.0247 0.0665
Trypanosoma brucei hypothetical protein, conserved 0.0055 0.0315 0.0883
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0063 0.0125
Echinococcus granulosus geminin 0.0357 0.233 0.2326
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0349 0.1035
Loa Loa (eye worm) hypothetical protein 0.005 0.0283 0.085
Leishmania major mitochondrial DNA polymerase beta 0.035 0.2278 0.7241
Giardia lamblia Sgs1 DNA helicase, putative 0.0023 0.0103 0.0488
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0791 0.5215 1
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0315 0.0925
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0155 0.098 0.3037
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0247 0.0665
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0023 0.0103 0.0098
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0055 0.0315 0.0883
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0048 0.0097
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0063 0.0069
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0283 0.1945
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0155 0.098 0.3037
Schistosoma mansoni alkaline phosphatase 0.0174 0.1108 0.1104
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.02 0.1279 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0023 0.0103 0.0098
Plasmodium falciparum glutathione reductase 0.0155 0.098 0.3037
Mycobacterium ulcerans hypothetical protein 0.005 0.0283 0.1945
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0283 0.0455
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0048 0.0043
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0063 0.0059
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0263 0.0259
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0247 0.0708
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.02 0.1279 1
Loa Loa (eye worm) oxidoreductase 0.0015 0.0048 0.0094
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0239 0.068
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0103 0.0241
Echinococcus multilocularis dnaJ subfamily B 0.0474 0.3103 0.3099
Schistosoma mansoni hypothetical protein 0.0018 0.0071 0.0067
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0102 0.0629 0.0625
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0247 0.0665
Plasmodium falciparum glutathione reductase 0.0478 0.3129 1
Echinococcus multilocularis cpg binding protein 0.0035 0.0184 0.0179
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0629 0.4917
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.01 0.0615 0.1919
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0277 0.0761
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0629 0.4917
Trichomonas vaginalis glutathione reductase, putative 0.0155 0.098 0.7657
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0155 0.098 0.3069
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0174 0.1108 0.1104
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0283 0.2057
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0199 0.0318
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0155 0.098 0.3069
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0185 0.0292
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0277 0.0804
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0102 0.0629 0.1901
Schistosoma mansoni hypothetical protein 0.0357 0.233 0.2326
Echinococcus multilocularis geminin 0.0357 0.233 0.2326
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0063 0.0059
Leishmania major NADH dehydrogenase, putative 0.0055 0.0315 0.0883
Brugia malayi glutamate synthase 0.0055 0.0315 0.0955
Trypanosoma cruzi polo-like protein kinase, putative 0.0102 0.0629 0.1939
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0103 0.0251
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0042 0.0047
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0055 0.0315 0.031
Brugia malayi polk-prov protein 0.0014 0.0042 0.0079
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0055 0.0315 0.246
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.1052 0.327
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0939 0.62 0.6198
Schistosoma mansoni hypothetical protein 0.009 0.0552 0.0547
Mycobacterium ulcerans dehydrogenase 0.0055 0.0315 0.2203
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0213 0.0627
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.003
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0063 0.0148
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0048 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0048 0.0044
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0155 0.098 0.3037
Echinococcus multilocularis glutamate synthase 0.0055 0.0315 0.031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0263 0.0259
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0055 0.0315 0.031
Echinococcus granulosus glutamate synthase 0.0055 0.0315 0.031
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0071 0.0173
Entamoeba histolytica disulphide oxidoreductase, putative 0.0055 0.0315 0.2311
Schistosoma mansoni disulfide oxidoreductase 0.0055 0.0315 0.031
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0369 0.111
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0791 0.5215 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0155 0.098 0.3069
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0055 0.0315 0.0955
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0055 0.0315 0.031
Entamoeba histolytica thioredoxin reductase, putative 0.02 0.1279 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0691 0.455 0.8713
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0247 0.0665
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0045 0.0247 0.0243
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0071 0.0173
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0055 0.0315 0.2311
Trichomonas vaginalis mercuric reductase, putative 0.0155 0.098 0.7657
Mycobacterium ulcerans glutamate synthase subunit beta 0.0055 0.0315 0.2203
Plasmodium vivax ferrodoxin reductase, putative 0.0055 0.0315 0.0934
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0048 0.0064
Mycobacterium tuberculosis Probable reductase 0.0691 0.455 0.8717
Plasmodium vivax glutathione reductase, putative 0.0478 0.3129 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0048 0.0043
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0055 0.0315 0.031
Trypanosoma cruzi trypanothione reductase, putative 0.0478 0.3129 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.003
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0055 0.0315 0.0542
Schistosoma mansoni hypothetical protein 0.0018 0.0071 0.0067
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0014 0.0042 0.0056
Brugia malayi AMP-binding enzyme family protein 0.005 0.0283 0.0853
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0048 0.0094
Schistosoma mansoni glutamate synthase 0.0055 0.0315 0.031
Onchocerca volvulus 0.0055 0.0315 0.4594
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0048 0.0026
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0048 0.0018
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.0048 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0263 0.0259
Onchocerca volvulus Serine\/threonine kinase homolog 0.0102 0.0629 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0155 0.098 0.3076
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0155 0.098 0.7577
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0045 0.0247 0.0665
Loa Loa (eye worm) hypothetical protein 0.0037 0.0199 0.058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0263 0.0259
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0055 0.0315 0.0883
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0055 0.0315 0.0925
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0247 0.0665
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0063 0.0069
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0048 0.0064
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0015 0.0048 0.0044
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0071 0.0171
Loa Loa (eye worm) thioredoxin reductase 0.0478 0.3129 1
Giardia lamblia Glutamate synthase 0.0055 0.0315 0.2203
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0028 0.0024
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0155 0.098 0.0975
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0102 0.0629 0.1963
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0048 0.0043
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.0048 0.0182
Brugia malayi ImpB/MucB/SamB family protein 0.0074 0.0444 0.137
Schistosoma mansoni hypothetical protein 0.0474 0.3103 0.3099
Brugia malayi glutathione reductase 0.0478 0.3129 1
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0055 0.0315 0.0883
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0247 0.0739
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0629 0.4917
Echinococcus multilocularis microtubule associated protein 2 0.1509 1 1
Trichomonas vaginalis glutamate synthase, putative 0.0055 0.0315 0.246
Loa Loa (eye worm) hypothetical protein 0.005 0.0283 0.085
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0239 0.0689
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0055 0.0315 0.0883
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0103 0.0802
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0063 0.0115
Schistosoma mansoni DNA polymerase IV / kappa 0.0014 0.0042 0.0037
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0419 0.0415
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0055 0.0315 0.0542
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0048 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0247 0.0665
Treponema pallidum oxidoreductase 0.0055 0.0315 0.2293
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0045 0.0247 0.0243
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0155 0.098 0.3037
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0045 0.0247 0.0736
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0094
Echinococcus granulosus dna polymerase eta 0.0074 0.0444 0.0439
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0055 0.0315 0.2203
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0048 0.0097
Schistosoma mansoni hypothetical protein 0.0357 0.233 0.2326
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0629 0.0625
Trichomonas vaginalis apoptosis inducing factor, putative 0.0055 0.0315 0.246
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0015 0.0048 0.0044
Plasmodium vivax thioredoxin reductase, putative 0.0478 0.3129 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0071 0.0067
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0283 0.1945
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0055 0.0315 0.2311
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0014 0.0042 0.0056
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.0048 0.0018
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0247 0.0665
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0283 0.2057
Trypanosoma cruzi NADH dehydrogenase, putative 0.0055 0.0315 0.0925
Echinococcus granulosus alkaline phosphatase 0.0174 0.1108 0.1104
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0103 0.0271
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0247 0.1658
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0155 0.098 0.0975
Schistosoma mansoni hypothetical protein 0.0018 0.0071 0.0067
Leishmania major DNA polymerase eta, putative 0.0074 0.0444 0.1301
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0048 0.0026
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0015 0.0048 0.0044
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0045 0.0247 0.1933
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0055 0.0315 0.031
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0102 0.0629 0.0625
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0048 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0283 0.1945

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.4654 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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