Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0101 | 0.5263 | 0.4297 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.011 | 0.5963 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 1 | 1 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.011 | 0.5963 | 0.5 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0035 | 0.0122 | 0.5 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0101 | 0.5263 | 0.4297 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0101 | 0.5263 | 0.5 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.011 | 0.5963 | 0.5 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0101 | 0.5263 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.0162 | 1 | 1 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0101 | 0.5263 | 0.5 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.011 | 0.5963 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0162 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 1 | 1 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0101 | 0.5263 | 0.5 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.011 | 0.5963 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.011 | 0.5963 | 0.5 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.011 | 0.5963 | 0.5 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0101 | 0.5263 | 1 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0101 | 0.5263 | 0.4297 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0101 | 0.5263 | 1 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0101 | 0.5263 | 1 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0101 | 0.5263 | 0.4297 |
Echinococcus granulosus | muscleblind protein | 0.0162 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.7865 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.9349 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.