Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0447 | 0.1583 | 0.1583 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0106 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.0835 | 0.0835 |
Onchocerca volvulus | 0.0447 | 0.1583 | 1 | |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0447 | 0.1583 | 0.1583 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.001 | 0.001 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0095 | 0.0095 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.0966 | 0.0966 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0447 | 0.1583 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0447 | 0.1583 | 0.1583 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0447 | 0.1583 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.0835 | 0.0835 |
Onchocerca volvulus | 0.0447 | 0.1583 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0447 | 0.1583 | 0.1583 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0088 | 0.0208 | 0.0208 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0036 | 0.001 | 0.001 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0083 | 0.0083 |
Brugia malayi | Carboxylesterase family protein | 0.0447 | 0.1583 | 0.1583 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0088 | 0.0208 | 0.0208 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0447 | 0.1583 | 0.1583 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0447 | 0.1583 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0036 | 0.001 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0447 | 0.1583 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0447 | 0.1583 | 0.1583 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.0149 | 0.0149 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0447 | 0.1583 | 0.1583 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0447 | 0.1583 | 0.1583 |
Echinococcus multilocularis | neuroligin | 0.0447 | 0.1583 | 0.1583 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.0966 | 0.0966 |
Loa Loa (eye worm) | hypothetical protein | 0.0447 | 0.1583 | 0.1583 |
Brugia malayi | hypothetical protein | 0.0286 | 0.0966 | 0.0966 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0447 | 0.1583 | 0.1583 |
Onchocerca volvulus | 0.016 | 0.0483 | 0.301 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2644 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.001 | 0.001 |
Brugia malayi | Carboxylesterase family protein | 0.2644 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0106 | 0.0277 | 0.0277 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0083 | 0.0083 |
Brugia malayi | Carboxylesterase family protein | 0.0447 | 0.1583 | 0.1583 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0447 | 0.1583 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0083 | 0.0083 |
Onchocerca volvulus | 0.0447 | 0.1583 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.2644 | 1 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0035 | 0.0005 | 0.0005 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2644 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.016 | 0.0483 | 0.0483 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0447 | 0.1583 | 0.1583 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0447 | 0.1583 | 0.1583 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0083 | 0.0083 |
Brugia malayi | hypothetical protein | 0.0447 | 0.1583 | 0.1583 |
Loa Loa (eye worm) | hypothetical protein | 0.0447 | 0.1583 | 0.1583 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0208 | 0.0208 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0095 | 0.0095 |
Onchocerca volvulus | 0.0058 | 0.0095 | 0.054 | |
Onchocerca volvulus | 0.0447 | 0.1583 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0447 | 0.1583 | 0.1583 |
Echinococcus granulosus | carboxylesterase 5A | 0.2644 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2644 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0149 | 0.0149 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0083 | 0.0083 |
Loa Loa (eye worm) | hypothetical protein | 0.0447 | 0.1583 | 0.1583 |
Brugia malayi | Carboxylesterase family protein | 0.0447 | 0.1583 | 0.1583 |
Onchocerca volvulus | 0.0447 | 0.1583 | 1 | |
Schistosoma mansoni | gliotactin | 0.0447 | 0.1583 | 0.1583 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0447 | 0.1583 | 0.1583 |
Loa Loa (eye worm) | carboxylesterase | 0.0447 | 0.1583 | 0.1583 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0277 | 0.0277 |
Echinococcus granulosus | neuroligin | 0.0447 | 0.1583 | 0.1583 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0106 | 0.0277 | 0.0277 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0088 | 0.0208 | 0.0208 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0083 | 0.0083 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.001 | 0.001 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.001 | 0.001 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0083 | 0.0083 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.001 | 0.001 |
Onchocerca volvulus | 0.0088 | 0.0208 | 0.1261 | |
Loa Loa (eye worm) | hypothetical protein | 0.0447 | 0.1583 | 0.1583 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0447 | 0.1583 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.2644 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2644 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2644 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2644 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2644 | 1 | 1 |
Onchocerca volvulus | 0.0286 | 0.0968 | 0.6087 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.0149 | 0.0149 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0036 | 0.001 | 0.001 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0447 | 0.1583 | 0.1583 |
Loa Loa (eye worm) | hypothetical protein | 0.0447 | 0.1583 | 0.1583 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0088 | 0.0208 | 0.0208 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0095 | 0.0095 |
Brugia malayi | Pre-SET motif family protein | 0.0036 | 0.001 | 0.001 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0083 | 0.0083 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.0966 | 0.0966 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0483 | 0.0483 |
Schistosoma mansoni | acetylcholinesterase | 0.0447 | 0.1583 | 0.1583 |
Echinococcus granulosus | acetylcholinesterase | 0.2644 | 1 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0.001 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0447 | 0.1583 | 0.1583 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0036 | 0.001 | 0.001 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0083 | 0.0083 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 22.3872 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.