Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 9 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | cytochrome P450, family 2, subfamily C, polypeptide 9 | 490 aa | 441 aa | 21.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2621 | 0.2621 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0065 | 0.3176 | 0.3176 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.3341 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0042 | 0.1847 | 0.5529 |
Onchocerca volvulus | 0.0042 | 0.1847 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1847 | 0.5529 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3341 | 0.3341 |
Onchocerca volvulus | Dual oxidase homolog | 0.0042 | 0.1847 | 1 |
Schistosoma mansoni | peroxidasin | 0.0042 | 0.1847 | 0.1847 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1847 | 0.5529 |
Brugia malayi | Animal haem peroxidase family protein | 0.0042 | 0.1847 | 0.5529 |
Schistosoma mansoni | hypothetical protein | 0.018 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0067 | 0.3341 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.3341 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1847 | 0.5529 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.3176 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.3341 | 0.3341 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2621 | 0.2621 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.3176 | 0.3176 |
Schistosoma mansoni | peroxidasin | 0.0042 | 0.1847 | 0.1847 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.3176 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1847 | 0.5529 |
Schistosoma mansoni | hypothetical protein | 0.018 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3341 | 0.3341 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1847 | 0.5529 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1847 | 0.5529 |
Brugia malayi | Animal haem peroxidase family protein | 0.0042 | 0.1847 | 0.5529 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1847 | 0.5529 |
Brugia malayi | Peroxidasin | 0.0042 | 0.1847 | 0.5529 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0042 | 0.1847 | 0.5529 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.3341 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.3341 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.3176 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1847 | 0.5529 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2621 | 0.2621 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0042 | 0.1847 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.1847 | 0.5529 |
Brugia malayi | Animal haem peroxidase family protein | 0.0042 | 0.1847 | 0.5529 |
Brugia malayi | Animal haem peroxidase family protein | 0.0042 | 0.1847 | 0.5529 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0065 | 0.3176 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.3176 | 0.3176 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.3341 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2621 | 0.7846 |
Onchocerca volvulus | 0.0042 | 0.1847 | 1 | |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0065 | 0.3176 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1847 | 0.5529 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3341 | 0.3341 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0042 | 0.1847 | 0.5529 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1847 | 0.5529 |
Brugia malayi | Blistered cuticle protein 3 | 0.0042 | 0.1847 | 0.5529 |
Echinococcus multilocularis | peroxidasin | 0.0042 | 0.1847 | 0.1847 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3341 | 0.3341 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2621 | 0.2621 |
Onchocerca volvulus | Peroxidase homolog | 0.0042 | 0.1847 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3341 | 0.3341 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.3341 | 0.3341 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2621 | 0.2621 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0042 | 0.1847 | 0.5529 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2621 | 0.7846 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1847 | 0.5529 |
Brugia malayi | Cytochrome P450 family protein | 0.0027 | 0.0976 | 0.292 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0042 | 0.1847 | 0.5529 |
Onchocerca volvulus | Peroxidasin homolog | 0.0042 | 0.1847 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1847 | 0.5529 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0065 | 0.3176 | 0.3176 |
Echinococcus granulosus | peroxidasin | 0.0042 | 0.1847 | 0.1847 |
Onchocerca volvulus | Peroxidasin homolog | 0.0042 | 0.1847 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0042 | 0.1847 | 0.5529 |
Echinococcus multilocularis | geminin | 0.018 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2621 | 0.2621 |
Onchocerca volvulus | 0.0042 | 0.1847 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1847 | 0.5529 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1847 | 0.5529 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0065 | 0.3176 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0027 | 0.0976 | 0.292 |
Onchocerca volvulus | Peroxidase homolog | 0.0042 | 0.1847 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2621 | 0.2621 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | = 19.95262315 uM | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
AC50 (functional) | = 39.81071706 uM | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
Potency (functional) | 2.2387 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.