TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 380.826 | Formula: C17H21ClN4O4
H donors: 0 H acceptors: 3 LogP: 0.89 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COCCN1CCN(CC1)C(=O)c1noc(c1)COc1cncc(c1)Cl
InChi: 1S/C17H21ClN4O4/c1-24-7-6-21-2-4-22(5-3-21)17(23)16-9-15(26-20-16)12-25-14-8-13(18)10-19-11-14/h8-11H,2-7,12H2,1H3
InChiKey: ASVDYYRNWYYFAZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	parathyroid hormone 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K04588 secretin receptor, putative	Get druggable targets OG5_139196	All targets in OG5_139196
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0388	1
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0235	0.0236
Schistosoma mansoni	zinc finger protein	0.0016	0.0123	0.0252
Brugia malayi	Bromodomain containing protein	0.008	0.2784	0.2789
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0856	0.0838
Brugia malayi	chromobox protein homolog 3	0.0043	0.1246	0.1249
Echinococcus multilocularis	lamin	0.0029	0.0643	0.0624
Echinococcus multilocularis	peregrin	0.0034	0.0846	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0621	0.0602
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0772	1
Echinococcus multilocularis	lamin dm0	0.0029	0.0643	0.0624
Brugia malayi	jmjC domain containing protein	0.004	0.1099	0.1101
Toxoplasma gondii	PHD-finger domain-containing protein	0.0031	0.0741	0.919
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0064	0.2102	0.2089
Schistosoma mansoni	hypothetical protein	0.0016	0.0123	0.0252
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.0388	0.5
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.005	0.1532	0.1517
Loa Loa (eye worm)	jmjC domain-containing protein	0.004	0.1099	0.1082
Brugia malayi	Muscleblind-like protein	0.016	0.61	0.6111
Schistosoma mansoni	jumonji domain containing protein	0.0081	0.2823	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.004	0.1099	0.3777
Brugia malayi	hypothetical protein	0.0253	0.9982	1
Echinococcus multilocularis	musashi	0.0029	0.0643	0.0624
Brugia malayi	Pre-SET motif family protein	0.0032	0.0772	0.0773
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0045	0.1299	0.4498
Echinococcus multilocularis	muscleblind protein	0.016	0.61	0.6103
Brugia malayi	PHD-finger family protein	0.0027	0.0552	0.0553
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.0388	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.1532	0.1517
Loa Loa (eye worm)	bromodomain containing protein	0.0019	0.0229	0.0208
Brugia malayi	SET domain containing protein	0.0014	0.0017	0.0017
Brugia malayi	Bromodomain containing protein	0.0034	0.0846	0.0848
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.0361	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1246	0.123
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.1951	0.1955
Loa Loa (eye worm)	PHD-finger family protein	0.0031	0.0741	0.0722
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0018	0.0201	0.0181
Loa Loa (eye worm)	jmjC domain-containing protein	0.0064	0.2124	0.2112
Plasmodium falciparum	phd finger protein, putative	0.0031	0.0741	1
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0446	0.0426
Echinococcus multilocularis	survival motor neuron protein 1	0.0253	0.9982	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0388	0.0368
Echinococcus multilocularis	zinc finger protein	0.0021	0.0314	0.0294
Echinococcus granulosus	jumonji domain containing protein	0.0043	0.125	0.1233
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0446	0.0426
Trichomonas vaginalis	set domain proteins, putative	0.0253	1	1
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0031	0.0741	0.2482
Giardia lamblia	PHD finger protein 15	0.0031	0.0741	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1669	0.1654
Brugia malayi	jmjC domain containing protein	0.0102	0.3697	0.3704
Loa Loa (eye worm)	hypothetical protein	0.016	0.61	0.6103
Schistosoma mansoni	ap endonuclease	0.0023	0.0388	0.1209
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0741	0.0722
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0085	0.0085
Schistosoma mansoni	hypothetical protein	0.0041	0.1157	0.3986
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0388	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0235	0.0657
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.1246	0.0893
Echinococcus granulosus	lamin	0.0029	0.0643	0.0624
Trichomonas vaginalis	chromobox protein, putative	0.0077	0.2662	0.2365
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0235	0.0215
Echinococcus multilocularis	jumonji domain containing protein	0.0043	0.125	0.1233
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0235	0.0215
Schistosoma mansoni	hypothetical protein	0.0052	0.1591	0.5553
Echinococcus multilocularis	muscleblind protein 1	0.016	0.61	0.6103
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0643	0.213
Loa Loa (eye worm)	hypothetical protein	0.0076	0.2594	0.2582
Echinococcus multilocularis	chromobox protein 1	0.0077	0.2662	0.2651
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0741	0.919
Brugia malayi	intermediate filament protein	0.0029	0.0643	0.0644
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.1246	0.0893
Loa Loa (eye worm)	hypothetical protein	0.0253	0.9982	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0235	0.0215
Brugia malayi	PHD-finger family protein	0.0031	0.0741	0.0742
Brugia malayi	Heterochromatin protein 1	0.0077	0.2662	0.2667
Schistosoma mansoni	hypothetical protein	0.0022	0.0361	0.111
Schistosoma mansoni	chromobox protein	0.0077	0.2662	0.9419
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0643	0.0624
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0235	0.0215
Schistosoma mansoni	hypothetical protein	0.0031	0.0741	0.2482
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0015	0.0053	0.0032
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0018	0.0201	0.0181
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0038	0.1043	0.1026
Echinococcus granulosus	peregrin	0.0034	0.0846	0.0828
Echinococcus granulosus	survival motor neuron protein 1	0.0253	0.9982	1
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0201	0.0534
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0235	0.0215
Loa Loa (eye worm)	hypothetical protein	0.016	0.61	0.6103
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0038	0.1043	0.1026
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.1951	0.1955
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0388	0.0368
Trichomonas vaginalis	chromobox protein, putative	0.0077	0.2662	0.2365
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0064	0.2102	0.2089
Echinococcus multilocularis	lysine specific demethylase 5A	0.0038	0.1014	0.0997
Echinococcus granulosus	muscleblind protein	0.016	0.61	0.6103
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0235	0.0215
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.1951	0.1938
Brugia malayi	CHD4 protein	0.0015	0.0053	0.0054
Schistosoma mansoni	ap endonuclease	0.0023	0.0388	0.1209
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0723	0.0704
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.1246	0.0645
Brugia malayi	Bromodomain containing protein	0.0041	0.1148	0.115
Schistosoma mansoni	hypothetical protein	0.0019	0.0235	0.0657
Trichomonas vaginalis	chromobox protein, putative	0.0047	0.1384	0.1036
Echinococcus granulosus	histone lysine methyltransferase setb	0.005	0.1532	0.1517
Echinococcus granulosus	lysine specific demethylase 5A	0.004	0.1099	0.1082
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0015	0.0053	0.0032
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.0388	0.5
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0388	1
Trichomonas vaginalis	chromobox protein, putative	0.0047	0.1384	0.1036
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0772	0.0753
Onchocerca volvulus		0.0052	0.1591	0.1013
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0772	0.2594
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0235	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1157	0.114
Loa Loa (eye worm)	heterochromatin protein 1	0.0077	0.2662	0.2651
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0643	0.0624
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.0388	0.5
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0031	0.0741	0.0722
Echinococcus granulosus	chromobox protein 1	0.0077	0.2662	0.2651
Schistosoma mansoni	lamin	0.0029	0.0643	0.213
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.1157	0.1159
Onchocerca volvulus	Alhambra homolog	0.0031	0.0741	0.0104
Onchocerca volvulus		0.0045	0.1299	0.0701
Schistosoma mansoni	hypothetical protein	0.0019	0.0235	0.0657
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0047	0.1384	0.0791
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0643	0.0644
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0235	0.0215
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0102	0.3697	0.3691
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0222	0.8718	0.8731
Echinococcus granulosus	GPCR family 2	0.0019	0.0235	0.0215
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0719	0.0345
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0201	0.0534
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.005	0.1532	0.5339
Echinococcus granulosus	lamin dm0	0.0029	0.0643	0.0624
Echinococcus granulosus	PHD finger protein rhinoceros	0.0031	0.0741	0.0722
Echinococcus granulosus	zinc finger protein	0.0021	0.0314	0.0294
Echinococcus granulosus	intermediate filament protein	0.0029	0.0643	0.0624
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0388	0.0389
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.005	0.1532	0.5339
Schistosoma mansoni	survival motor neuron protein	0.0052	0.1591	0.5553
Loa Loa (eye worm)	CHromoDomain protein family member	0.0015	0.0053	0.0032
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0023	0.0388	0.5
Toxoplasma gondii	PHD-finger domain-containing protein	0.0031	0.0741	0.919
Schistosoma mansoni	chromobox protein	0.0077	0.2662	0.9419
Schistosoma mansoni	lamin	0.0029	0.0643	0.213
Onchocerca volvulus		0.0034	0.0856	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0044	0.1257	0.1241
Schistosoma mansoni	zinc finger protein	0.0021	0.0314	0.094
Plasmodium vivax	SET domain protein, putative	0.0032	0.0772	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0235	0.0657
Loa Loa (eye worm)	hypothetical protein	0.006	0.1951	0.1938
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0085	0.0064
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0102	0.3697	0.3691
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0446	0.1418
Echinococcus granulosus	chromobox protein 1	0.0077	0.2662	0.2651
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0388	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.004	0.1099	0.3777
Schistosoma mansoni	bromodomain containing protein	0.0068	0.2262	0.7975
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0388	0.0368
Brugia malayi	Pre-SET motif family protein	0.0222	0.8718	0.8734
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0719	0.0345
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.1591	0.1594
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1342	0.1326
Echinococcus multilocularis	chromobox protein 1	0.0077	0.2662	0.2651
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0643	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1152	0.1135

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.8888 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1707610

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1534672