Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutaminase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trichomonas vaginalis | glutaminase, putative | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Mycobacterium ulcerans | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Loa Loa (eye worm) | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Schistosoma mansoni | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Loa Loa (eye worm) | glutaminase 2 | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Brugia malayi | glutaminase DH11.1 | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.083 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.083 | 1 | 0.5 |
Mycobacterium ulcerans | glutaminase | 0.033 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.083 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.083 | 1 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.083 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.083 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.083 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.083 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.083 | 1 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.083 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.083 | 1 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.033 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.083 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.9811 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.2753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.