Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | para nitrobenzyl esterase | 0.014 | 0.1097 | 0.1321 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0043 | 0.0078 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.0829 | 0.8307 | 0.8307 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.014 | 0.1097 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.014 | 0.1097 | 0.1321 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0078 | 0.0093 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.014 | 0.1097 | 0.1321 |
Brugia malayi | Carboxylesterase family protein | 0.014 | 0.1097 | 0.1321 |
Onchocerca volvulus | 0.014 | 0.1097 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0829 | 0.8307 | 0.8307 |
Echinococcus granulosus | neuroligin | 0.014 | 0.1097 | 0.1321 |
Loa Loa (eye worm) | carboxylesterase | 0.014 | 0.1097 | 0.1097 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0263 | 0.0263 |
Echinococcus granulosus | BC026374 protein S09 family | 0.014 | 0.1097 | 0.1321 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.014 | 0.1097 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0829 | 0.8307 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0829 | 0.8307 | 0.8307 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.0392 | 0.0392 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0829 | 0.8307 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1097 | 0.1097 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.014 | 0.1097 | 0.5 |
Plasmodium falciparum | phd finger protein, putative | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1097 | 0.1097 |
Giardia lamblia | PHD finger protein 15 | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | gliotactin | 0.014 | 0.1097 | 0.1321 |
Brugia malayi | jmjC domain containing protein | 0.0043 | 0.0078 | 0.0093 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 0.0838 | 0.1009 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.0078 | 0.0093 |
Brugia malayi | Carboxylesterase family protein | 0.014 | 0.1097 | 0.1321 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.014 | 0.1097 | 0.5 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0829 | 0.8307 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1097 | 0.1097 |
Brugia malayi | Carboxylesterase family protein | 0.014 | 0.1097 | 0.1321 |
Onchocerca volvulus | 0.014 | 0.1097 | 1 | |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0078 | 0.0093 |
Schistosoma mansoni | acetylcholinesterase | 0.014 | 0.1097 | 0.1321 |
Echinococcus granulosus | carboxylesterase 5A | 0.0829 | 0.8307 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.014 | 0.1097 | 0.1321 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1097 | 0.1097 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 0.0838 | 0.1009 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1097 | 0.1097 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1097 | 0.1097 |
Echinococcus multilocularis | neuroligin | 0.014 | 0.1097 | 0.1321 |
Onchocerca volvulus | 0.014 | 0.1097 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.014 | 0.1097 | 0.1321 |
Echinococcus multilocularis | acetylcholinesterase | 0.0829 | 0.8307 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.014 | 0.1097 | 0.1321 |
Loa Loa (eye worm) | carboxylesterase | 0.014 | 0.1097 | 0.1097 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0829 | 0.8307 | 0.8307 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.014 | 0.1097 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0829 | 0.8307 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.0144 | 0.0174 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.014 | 0.1097 | 0.1321 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.014 | 0.1097 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0043 | 0.0078 | 0.0093 |
Onchocerca volvulus | 0.014 | 0.1097 | 1 | |
Onchocerca volvulus | 0.014 | 0.1097 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0991 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0829 | 0.8307 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0829 | 0.8307 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0115 | 0.0838 | 0.1009 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.0144 | 0.0174 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.014 | 0.1097 | 0.1321 |
Brugia malayi | Carboxylesterase family protein | 0.014 | 0.1097 | 0.1321 |
Echinococcus granulosus | acetylcholinesterase | 0.0829 | 0.8307 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.014 | 0.1097 | 0.1321 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1097 | 0.1097 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.014 | 0.1097 | 0.1321 |
Brugia malayi | hypothetical protein | 0.014 | 0.1097 | 0.1321 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.059 | 0.0711 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.