Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.014 | 1 | 0.5 |
Trypanosoma brucei | ornithine decarboxylase | 0.0128 | 0.8693 | 0.5 |
Entamoeba histolytica | ornithine decarboxylase, putative | 0.0128 | 0.8693 | 0.5 |
Leishmania major | ornithine decarboxylase, putative | 0.0128 | 0.8693 | 0.5 |
Toxoplasma gondii | diaminopimelate decarboxylase | 0.0128 | 0.8693 | 0.5 |
Trichomonas vaginalis | ornithine decarboxylase, putative | 0.0128 | 0.8693 | 1 |
Trichomonas vaginalis | pyridoxal-dependent decarboxylase, putative | 0.0128 | 0.8693 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.014 | 1 | 0.5 |
Mycobacterium tuberculosis | Diaminopimelate decarboxylase LysA (DAP decarboxylase) | 0.0128 | 0.8693 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.014 | 1 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.014 | 1 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.014 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.014 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.014 | 1 | 0.5 |
Plasmodium vivax | S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative | 0.0128 | 0.8693 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.014 | 1 | 1 |
Onchocerca volvulus | 0.0128 | 0.8693 | 0.5 | |
Trichomonas vaginalis | diaminopimelate decarboxylase, putative | 0.0128 | 0.8693 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 1 | 1 |
Mycobacterium ulcerans | diaminopimelate decarboxylase LysA | 0.0128 | 0.8693 | 0.5 |
Trichomonas vaginalis | ornithine decarboxylase, putative | 0.0128 | 0.8693 | 1 |
Trichomonas vaginalis | diaminopimelate decarboxylase, putative | 0.0128 | 0.8693 | 1 |
Plasmodium falciparum | S-adenosylmethionine decarboxylase/ornithine decarboxylase | 0.0128 | 0.8693 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.014 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE DIAMINOPIMELATE DECARBOXYLASE LYSA (DAP DECARBOXYLASE) | 0.0049 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.014 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 1 | 1 |
Giardia lamblia | Ornithine decarboxylase | 0.0128 | 0.8693 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.