Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0054 | 0.0054 |
Echinococcus multilocularis | transfer RNA-Lys | 0.004 | 0.0952 | 0.0214 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0054 | 0.1851 | 0.1235 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0764 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3334 | 0.2919 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.196 | 0.1359 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0764 | 0.5 |
Brugia malayi | hypoxia-induced factor 1 | 0.0166 | 0.9101 | 0.9101 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.196 | 0.1359 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3334 | 0.2919 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3334 | 0.3334 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0054 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.7707 | 0.7707 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.196 | 0.1359 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0166 | 0.9101 | 0.9101 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0054 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3334 | 0.2919 |
Mycobacterium ulcerans | putative regulatory protein | 0.004 | 0.0952 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.196 | 0.196 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0054 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.196 | 0.196 |
Echinococcus granulosus | single minded 2 | 0.004 | 0.0952 | 0.0214 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.7707 | 0.7707 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3334 | 0.2919 |
Onchocerca volvulus | 0.004 | 0.0952 | 0.5 | |
Echinococcus multilocularis | geminin | 0.0173 | 0.9568 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3334 | 0.3334 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.196 | 0.1359 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3334 | 0.3334 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0764 | 0.5 |
Brugia malayi | PAS domain containing protein | 0.0054 | 0.1851 | 0.1851 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3334 | 0.2919 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0054 | 0.5 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0054 | 0.0054 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.7707 | 0.7707 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0764 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0054 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3334 | 0.3334 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0054 | 0.5 |
Schistosoma mansoni | single-minded | 0.0054 | 0.1851 | 0.1235 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0054 | 0.5 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0764 | 0.0764 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.9568 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3334 | 0.2919 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3334 | 0.3334 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3334 | 0.2919 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.196 | 0.1359 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.196 | 0.1359 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3334 | 0.3334 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.9568 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.196 | 0.1359 |
Brugia malayi | bHLH-PAS transcription factor | 0.004 | 0.0952 | 0.0952 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0054 | 0.5 |
Echinococcus granulosus | geminin | 0.0173 | 0.9568 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.