Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | somatostatin receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | somatostatin receptor 2 | 369 aa | 411 aa | 18.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | 0.0086 | 0.3945 | 1 | |
Onchocerca volvulus | 0.0066 | 0.1812 | 0.4593 | |
Loa Loa (eye worm) | trypsin family protein | 0.0066 | 0.1812 | 0.1812 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0086 | 0.3945 | 0.3945 |
Mycobacterium ulcerans | hypothetical protein | 0.0066 | 0.1812 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.3945 | 0.3945 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0049 | 0 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0066 | 0.1812 | 0.1812 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.1812 | 0.1812 |
Brugia malayi | Protein kinase domain containing protein | 0.0086 | 0.3945 | 0.3945 |
Brugia malayi | Trypsin family protein | 0.0066 | 0.1812 | 0.1812 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.1812 | 0.1812 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0066 | 0.1812 | 0.1812 |
Onchocerca volvulus | 0.0066 | 0.1812 | 0.4593 | |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0086 | 0.3945 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0142 | 1 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0049 | 0 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0086 | 0.3945 | 0.3945 |
Toxoplasma gondii | kringle domain-containing protein | 0.0086 | 0.3945 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.1812 | 0.1812 |
Onchocerca volvulus | 0.0066 | 0.1812 | 0.4593 | |
Leishmania major | hypothetical protein, conserved | 0.0086 | 0.3945 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0086 | 0.3945 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0086 | 0.3945 | 0.2605 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.1812 | 0.1812 |
Loa Loa (eye worm) | carboxylesterase | 0.0142 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0066 | 0.1812 | 0.1812 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.1812 | 0.1812 |
Onchocerca volvulus | 0.0066 | 0.1812 | 0.4593 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0142 | 1 | 1 |
Onchocerca volvulus | 0.0066 | 0.1812 | 0.4593 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0142 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0142 | 1 | 1 |
Onchocerca volvulus | 0.0066 | 0.1812 | 0.4593 | |
Schistosoma mansoni | hypothetical protein | 0.0086 | 0.3945 | 0.2605 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.1812 | 0.1812 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0086 | 0.3945 | 0.2605 |
Echinococcus multilocularis | acetylcholinesterase | 0.0142 | 1 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.1812 | 0.1812 |
Echinococcus multilocularis | acetylcholinesterase | 0.0142 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0142 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0142 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0142 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0066 | 0.1812 | 0.1812 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 1 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0049 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0086 | 0.3945 | 0.5 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0066 | 0.1812 | 0.1812 |
Brugia malayi | Trypsin family protein | 0.0066 | 0.1812 | 0.1812 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9.2 nM | Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cells | ChEMBL. | 11591512 |
IC50 (binding) | = 9.2 nM | Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cells | ChEMBL. | 11591512 |
IC50 (functional) | = 7700 nM | Antagonistic activity of the compound towards sst2 receptor in GH4C1 cells a concentration of 1-2 x 10e6/mL incubated for 20 minutes | ChEMBL. | 11591512 |
IC50 (functional) | = 7700 nM | Antagonistic activity of the compound towards sst2 receptor in GH4C1 cells a concentration of 1-2 x 10e6/mL incubated for 20 minutes | ChEMBL. | 11591512 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.