Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0132 | 0.3661 | 0.9946 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0926 | 0.0926 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0288 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0132 | 0.3661 | 0.9946 |
Echinococcus multilocularis | tar DNA binding protein | 0.0132 | 0.3661 | 0.3661 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0015 | 0.0041 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0926 | 0.0926 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0926 | 0.0926 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0559 | 0.1518 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0288 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0132 | 0.3661 | 0.9946 |
Brugia malayi | MH2 domain containing protein | 0.0133 | 0.3681 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0926 | 0.0926 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0132 | 0.3661 | 0.9946 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0926 | 0.2517 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0926 | 0.2517 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.104 | 0.2826 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0926 | 0.0926 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0926 | 0.0926 |
Echinococcus multilocularis | geminin | 0.0335 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3661 | 0.3661 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0288 | 0.0782 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0559 | 0.0559 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.104 | 0.2826 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0288 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0926 | 0.0926 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.104 | 0.2826 |
Schistosoma mansoni | hypothetical protein | 0.0335 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0133 | 0.3681 | 1 |
Brugia malayi | RNA binding protein | 0.0132 | 0.3661 | 0.9946 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0133 | 0.3681 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3661 | 0.3661 |
Schistosoma mansoni | hypothetical protein | 0.0335 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0132 | 0.3661 | 0.3661 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0288 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0288 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.104 | 0.2826 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0132 | 0.3661 | 0.9946 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0288 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3661 | 0.3661 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0559 | 0.1518 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3661 | 0.3661 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0288 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3661 | 0.3661 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0288 | 0.0782 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0288 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.