Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | S-adenosylmethionine decarboxylase proenzyme, putative | 0.0107 | 1 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4394 | 0.4078 |
Trypanosoma cruzi | S-adenosylmethionine decarboxylase proenzyme, putative | 0.0107 | 1 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4394 | 0.4078 |
Leishmania major | S-adenosylmethionine decarboxylase | 0.0107 | 1 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4394 | 0.4078 |
Plasmodium vivax | S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative | 0.0052 | 0 | 0.5 |
Trypanosoma cruzi | S-adenosylmethionine decarboxylase proenzyme, putative | 0.0107 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4394 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4394 | 0.4078 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4394 | 0.4078 |
Plasmodium falciparum | S-adenosylmethionine decarboxylase/ornithine decarboxylase | 0.0052 | 0 | 0.5 |
Trypanosoma brucei | S-adenosylmethionine decarboxylase | 0.0107 | 1 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4394 | 0.4078 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4394 | 1 |
Echinococcus granulosus | S adenosylmethionine decarboxylase proenzyme | 0.0107 | 1 | 1 |
Echinococcus multilocularis | S adenosylmethionine decarboxylase proenzyme | 0.0107 | 1 | 1 |
Loa Loa (eye worm) | S-adenosylmethionine decarboxylase proenzyme | 0.0107 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4394 | 1 |
Trypanosoma brucei | S-adenosylmethionine decarboxylase | 0.0107 | 1 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4394 | 0.4078 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4394 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4394 | 0.4078 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4394 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.631 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.