Detailed information for compound 1535594

Basic information

Technical information
  • TDR Targets ID: 1535594
  • Name: ZU-4242639
  • MW: 293.318 | Formula: C14H19N3O4
  • H donors: 0 H acceptors: 4 LogP: 1.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=O)Cn1cc(ccc1=O)[N+](=O)[O-])C1CCCCC1
  • InChi: 1S/C14H19N3O4/c1-15(11-5-3-2-4-6-11)14(19)10-16-9-12(17(20)21)7-8-13(16)18/h7-9,11H,2-6,10H2,1H3
  • InChiKey: CYPCELHEHJMQAG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0067 0.0193
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0179 0.0517
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.0141 0.0349
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0653 0.3473 1
Echinococcus multilocularis GPCR, family 2 0.0053 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0042
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.0837 0.0837
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0012 0.0029
Onchocerca volvulus 0.0103 0.042 0.221
Schistosoma mansoni thyroid hormone receptor 0.003 0.0012 0.0029
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0042
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0125 0.031
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0169 0.0419
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0012 0.0042
Schistosoma mansoni hypothetical protein 0.0045 0.0095 0.0235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0012 0.0042
Loa Loa (eye worm) hypothetical protein 0.0057 0.0162 0.0577
Onchocerca volvulus 0.037 0.19 1
Loa Loa (eye worm) inositol-1 0.0083 0.031 0.1104
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0012 0.0029
Brugia malayi nuclear hormone receptor 0.003 0.0012 0.0042
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0169 0.0419
Echinococcus granulosus Niemann Pick C1 protein 0.0154 0.0702 0.1738
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0161 0.0399
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0179 0.0179
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0081 0.0298 0.0298
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0176 0.0176
Brugia malayi CHE-14 protein 0.0046 0.0104 0.0371
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0161 0.0399
Entamoeba histolytica hypothetical protein 0.0081 0.0298 0.6103
Loa Loa (eye worm) dihydrofolate reductase 0.0497 0.261 0.9293
Loa Loa (eye worm) hypothetical protein 0.0114 0.0481 0.1714
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0125 0.0446
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0067 0.0193
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0012 0.0029
Brugia malayi intermediate filament protein 0.0031 0.0021 0.0076
Schistosoma mansoni lamin 0.0031 0.0021 0.0053
Echinococcus multilocularis survival motor neuron protein 1 0.0533 0.2808 0.2808
Loa Loa (eye worm) hypothetical protein 0.0031 0.0021 0.0076
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0067 0.0193
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0067 0.0239
Brugia malayi jmjC domain containing protein 0.0058 0.0169 0.0602
Echinococcus multilocularis tumor protein p63 0.0392 0.2026 0.2026
Brugia malayi hypothetical protein 0.0533 0.2808 1
Schistosoma mansoni hypothetical protein 0.0045 0.0095 0.0235
Schistosoma mansoni dihydrofolate reductase 0.0497 0.261 0.6462
Brugia malayi steroid hormone receptor 0.003 0.0012 0.0042
Echinococcus multilocularis protein dispatched 1 0.0053 0.014 0.014
Echinococcus multilocularis microtubule associated protein 2 0.0755 0.4038 0.4038
Echinococcus multilocularis inositol monophosphatase 1 0.0083 0.031 0.031
Schistosoma mansoni transcription factor LCR-F1 0.0081 0.0298 0.0738
Schistosoma mansoni inositol monophosphatase 0.0083 0.031 0.0768
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0067 0.0239
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0176 0.032
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0176 0.0507
Echinococcus multilocularis lamin 0.0031 0.0021 0.0021
Echinococcus granulosus lamin dm0 0.0031 0.0021 0.0053
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.0141 0.0502
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0083 0.031 0.5
Schistosoma mansoni microtubule-associated protein tau 0.0755 0.4038 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0179 0.0075
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0083 0.031 0.0608
Schistosoma mansoni hypothetical protein 0.0045 0.0095 0.0235
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0176 0.0627
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0176 0.144
Schistosoma mansoni alpha-glucosidase 0.0153 0.0699 0.1731
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0083 0.031 0.0713
Brugia malayi Dihydrofolate reductase 0.0497 0.261 0.9293
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0653 0.3473 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0012 0.0042
Brugia malayi hypothetical protein 0.0081 0.0298 0.1061
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0167 0.0774 0.2758
Schistosoma mansoni hypothetical protein 0.0081 0.0298 0.0738
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0176 0.144
Onchocerca volvulus Huntingtin homolog 0.0276 0.1381 0.7272
Loa Loa (eye worm) hypothetical protein 0.0108 0.0445 0.1586
Echinococcus granulosus lysosomal alpha glucosidase 0.0178 0.0837 0.2073
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0179 0.0444
Brugia malayi hypothetical protein 0.0176 0.0824 0.2934
Echinococcus granulosus tumor protein p63 0.0392 0.2026 0.5018
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0176 0.0436
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0104 0.0489
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0012 0.0042
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0012 0.0042
Echinococcus granulosus FTZ F1 alpha 0.003 0.0012 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0012 0.0042
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0104 0.0258
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0166 0.0412
Brugia malayi ecdysteroid receptor 0.003 0.0012 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0125 0.031
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.0455 0.1126
Onchocerca volvulus 0.0057 0.0166 0.0876
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0653 0.3473 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0042
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0176 0.0176
Loa Loa (eye worm) zinc finger protein 0.0338 0.1726 0.6145
Brugia malayi MH2 domain containing protein 0.0131 0.0573 0.2039
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0169 0.0419
Brugia malayi Zinc finger, C2H2 type family protein 0.0338 0.1726 0.6145
Echinococcus granulosus survival motor neuron protein 1 0.0533 0.2808 0.6954
Brugia malayi jmjC domain containing protein 0.0058 0.0169 0.0602
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0104 0.0371
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0176 0.5
Schistosoma mansoni hypothetical protein 0.0045 0.0095 0.0235
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0161 0.0574
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0128 0.0558 0.1381
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0012 0.0042
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0178 0.0837 0.298
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0108 0.0445 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0176 0.0507
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0083 0.031 0.0893
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0497 0.261 1
Schistosoma mansoni hypothetical protein 0.0053 0.0141 0.0349
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0169 0.0419
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0012 0.0012
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0179 0.033
Schistosoma mansoni patched 1 0.0046 0.0104 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0176 0.0824 1
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0176 0.144
Loa Loa (eye worm) hypothetical protein 0.0276 0.1381 0.4919
Schistosoma mansoni hypothetical protein 0.0114 0.0481 0.1192
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0179 0.0075
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.0141 0.0502
Echinococcus multilocularis thymidylate synthase 0.037 0.19 0.19
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0012 0.0029
Schistosoma mansoni thyroid hormone receptor 0.003 0.0012 0.0029
Mycobacterium ulcerans thymidylate synthase 0.037 0.19 0.7101
Schistosoma mansoni lamin 0.0031 0.0021 0.0053
Loa Loa (eye worm) hypothetical protein 0.0031 0.0018 0.0065
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0083 0.031 0.642
Entamoeba histolytica hypothetical protein 0.0081 0.0298 0.6103
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0176 0.0436
Entamoeba histolytica hypothetical protein 0.0081 0.0298 0.6103
Onchocerca volvulus 0.0031 0.0021 0.0113
Echinococcus multilocularis lamin dm0 0.0031 0.0021 0.0021
Trichomonas vaginalis inositol monophosphatase, putative 0.0083 0.031 0.321
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0012 0.0062
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.0141 0.0141
Brugia malayi follicle stimulating hormone receptor 0.0253 0.1254 0.4466
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0125 0.0446
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0012 0.0029
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0012 0.0029
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0012 0.0029
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0179 0.0075
Echinococcus granulosus intermediate filament protein 0.0031 0.0021 0.0053
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0179 0.0444
Loa Loa (eye worm) hypothetical protein 0.0533 0.2808 1
Mycobacterium tuberculosis Hypothetical protein 0.0176 0.0824 0.2707
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0176 0.0507
Brugia malayi Latrophilin receptor protein 2 0.0053 0.0141 0.0502
Schistosoma mansoni survival motor neuron protein 0.0109 0.0451 0.1118
Echinococcus granulosus zinc finger transcription factor gli2 0.0338 0.1726 0.4273
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0012 0.0042
Echinococcus multilocularis Niemann Pick C1 protein 0.0154 0.0702 0.0702
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0012 0.0029
Echinococcus granulosus GPCR family 2 0.0053 0.0141 0.0349
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0012 0.0042
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0104 0.0104
Brugia malayi nuclear receptor NHR-88 0.003 0.0012 0.0042
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0176 0.032
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0109 0.0451 0.1608
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0125 0.0125
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0497 0.261 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.0445 0.0445
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0012 0.0042
Onchocerca volvulus 0.0109 0.0451 0.2376
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0128 0.0558 0.0558
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.0837 0.0837
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0083 0.031 0.321
Loa Loa (eye worm) hypothetical protein 0.0114 0.048 0.171
Loa Loa (eye worm) thymidylate synthase 0.037 0.19 0.6765
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0042
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0012 0.0029
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0012 0.0012
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.014 0.0499
Echinococcus multilocularis musashi 0.0031 0.0021 0.0021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0167 0.0774 0.2758
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.037 0.19 0.7101
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0012 0.0012
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0169 0.0169
Brugia malayi hypothetical protein 0.0276 0.1381 0.4919
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0125 0.0125
Schistosoma mansoni alpha glucosidase 0.004 0.0067 0.0166
Entamoeba histolytica hypothetical protein 0.0081 0.0298 0.6103
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0176 0.032
Echinococcus granulosus expressed conserved protein 0.0101 0.0409 0.1013
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0012 0.0042
Schistosoma mansoni alpha-glucosidase 0.0153 0.0699 0.1731
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0104 0.0258
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0012 0.0062
Schistosoma mansoni hypothetical protein 0.0053 0.0141 0.0349
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0161 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0012 0.0042
Brugia malayi dihydrofolate reductase family protein 0.0497 0.261 0.9293
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0083 0.031 0.321
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0012 0.0042
Echinococcus granulosus microtubule associated protein 2 0.0755 0.4038 1
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0012 0.0062
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0179 0.0444
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0167 0.0774 0.2758
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0012 0.0012
Brugia malayi MAP kinase sur-1 0.0059 0.0176 0.0627
Schistosoma mansoni intermediate filament proteins 0.0031 0.0021 0.0053
Loa Loa (eye worm) hypothetical protein 0.0046 0.0104 0.0371
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0161 0.0161
Echinococcus multilocularis expressed conserved protein 0.0101 0.0409 0.0409
Echinococcus multilocularis zinc finger transcription factor gli2 0.0338 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0042
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0012 0.0012
Echinococcus granulosus dihydrofolate reductase 0.0497 0.261 0.6462
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0176 0.144
Echinococcus multilocularis protein patched 0.0046 0.0104 0.0104
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0067 0.0166
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0012 0.0042
Schistosoma mansoni coup transcription factor 0.003 0.0012 0.0029
Trypanosoma brucei protein kinase, putative 0.0059 0.0176 0.032
Brugia malayi thymidylate synthase 0.037 0.19 0.6765
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.0445 0.1103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0012 0.0042
Brugia malayi Steroid receptor seven-up type 2 0.0128 0.0558 0.1985
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0169 0.0169
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0012 0.0012
Echinococcus granulosus inositol monophosphatase 1 0.0083 0.031 0.0768
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0176 0.0436
Echinococcus granulosus lamin 0.0031 0.0021 0.0053
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.0573 0.2039
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0053 0.0141 0.0349
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0083 0.031 0.0893
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0125 0.031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0012 0.0042
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0012 0.0029
Brugia malayi Inositol-1 0.0083 0.031 0.1104
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0021 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0012 0.0042
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0169 0.0602
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0012 0.0042
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0075 0.0262 0.041
Brugia malayi Glycosyl hydrolases family 31 protein 0.0178 0.0837 0.298
Echinococcus multilocularis dihydrofolate reductase 0.0497 0.261 0.261
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0169 0.0419
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0125 0.031
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0653 0.3473 1
Schistosoma mansoni hypothetical protein 0.0109 0.0451 0.1118
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0497 0.261 1
Loa Loa (eye worm) nuclear hormone receptor 0.0112 0.0471 0.1677
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0053 0.0141 0.0141
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.037 0.19 0.4705
Brugia malayi latrophilin 2 splice variant baaae 0.0114 0.0481 0.1714
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0125 0.031
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0021 0.0076
Brugia malayi Calcitonin receptor-like protein seb-1 0.0167 0.0774 0.2758
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0012 0.0042
Schistosoma mansoni inositol monophosphatase 0.0083 0.031 0.0768
Schistosoma mansoni hypothetical protein 0.0053 0.0141 0.0349
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0012 0.0042
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0253 0.1254 0.4466
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0012 0.0029
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0176 0.0824 0.2372
Schistosoma mansoni hypothetical protein 0.0053 0.0141 0.0349
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0012 0.0042
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0012 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0012 0.0042
Loa Loa (eye worm) hypothetical protein 0.0053 0.0141 0.0502
Brugia malayi Niemann-Pick C1 protein precursor 0.0108 0.0445 0.1586
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0012 0.0042
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.037 0.19 0.6977
Chlamydia trachomatis dihydrofolate reductase 0.0497 0.261 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0012 0.0029
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0083 0.031 0.0893
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0653 0.3473 1
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0021 0.0076
Echinococcus granulosus thymidylate synthase 0.037 0.19 0.4705
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.0573 0.2039
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0081 0.0298 0.0738
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0176 0.0507
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0012 0.0029
Onchocerca volvulus 0.0031 0.0021 0.0113
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0012 0.0029
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0653 0.3473 0.5
Loa Loa (eye worm) hypothetical protein 0.0057 0.0166 0.0593
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0012 0.0029
Onchocerca volvulus 0.003 0.0012 0.0062
Schistosoma mansoni nuclear hormone receptor 0.003 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0042
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0042
Loa Loa (eye worm) hypothetical protein 0.0276 0.1381 0.4919
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0176 0.0507
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0083 0.031 0.0713
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0067 0.0067
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0179 0.0075
Onchocerca volvulus Huntingtin homolog 0.0276 0.1381 0.7272

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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