Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutaminase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Brugia malayi | glutaminase DH11.1 | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Loa Loa (eye worm) | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Loa Loa (eye worm) | glutaminase 2 | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Trichomonas vaginalis | glutaminase, putative | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Mycobacterium ulcerans | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutaminase 2 | 0.033 | 0.0127 | 0.0127 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1352 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1352 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1352 | 1 | 1 |
Mycobacterium ulcerans | glutaminase | 0.033 | 0.0127 | 0.0127 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0834 | 0.4994 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0834 | 0.4994 | 0.5 |
Schistosoma mansoni | glutaminase | 0.033 | 0.0127 | 0.0127 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1352 | 1 | 1 |
Onchocerca volvulus | 0.0317 | 0 | 0.5 | |
Brugia malayi | Dihydrofolate reductase | 0.1352 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0834 | 0.4994 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1352 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.1352 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0834 | 0.4994 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1352 | 1 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.033 | 0.0127 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0834 | 0.4994 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.033 | 0.0127 | 0.0127 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0834 | 0.4994 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1352 | 1 | 0.5 |
Loa Loa (eye worm) | glutaminase | 0.033 | 0.0127 | 0.0127 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.