Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | Thymidylate kinase, putative | 0.0075 | 0.0044 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0438 | 0.0864 | 0.087 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0438 | 0.0864 | 0.087 |
Onchocerca volvulus | 0.425 | 0.9474 | 1 | |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0397 | 0.0771 | 0.073 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0438 | 0.0864 | 1 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0075 | 0.0044 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0438 | 0.0864 | 0.0912 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0438 | 0.0864 | 0.087 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2022 | 0.4442 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYX (TS) (TSase) | 0.1667 | 0.3641 | 0.3814 |
Echinococcus granulosus | dihydrofolate reductase | 0.0438 | 0.0864 | 0.0912 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0397 | 0.0771 | 0.073 |
Brugia malayi | thymidylate kinase | 0.0075 | 0.0044 | 0.0047 |
Schistosoma mansoni | dihydrofolate reductase | 0.0438 | 0.0864 | 0.0912 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.2022 | 0.4442 | 0.4417 |
Brugia malayi | hypothetical protein | 0.2022 | 0.4442 | 0.4688 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4483 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyX (ts) (TSase) | 0.1667 | 0.3641 | 0.3814 |
Schistosoma mansoni | thymidylate kinase | 0.0075 | 0.0044 | 0.0047 |
Loa Loa (eye worm) | thymidylate kinase | 0.0075 | 0.0044 | 0.0047 |
Echinococcus multilocularis | thymidylate kinase | 0.0075 | 0.0044 | 0.0047 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.0201 | 0.0212 |
Brugia malayi | dihydrofolate reductase family protein | 0.0438 | 0.0864 | 0.0912 |
Mycobacterium tuberculosis | Hypothetical protein | 0.2022 | 0.4442 | 0.4663 |
Leishmania major | deoxyuridine triphosphatase, putative,dUTP diphosphatase | 0.0397 | 0.0771 | 0.073 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.425 | 0.9474 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0438 | 0.0864 | 0.0912 |
Loa Loa (eye worm) | thymidylate synthase | 0.425 | 0.9474 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.425 | 0.9474 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0438 | 0.0864 | 0.0912 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4483 | 1 | 1 |
Schistosoma mansoni | thymidylate kinase | 0.0075 | 0.0044 | 0.0047 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0075 | 0.0044 | 0.5 |
Brugia malayi | thymidylate synthase | 0.425 | 0.9474 | 1 |
Echinococcus granulosus | thymidylate kinase | 0.0075 | 0.0044 | 0.0047 |
Trypanosoma brucei | deoxyuridine triphosphatase, putative | 0.0397 | 0.0771 | 0.073 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.4483 | 1 | 1 |
Mycobacterium ulcerans | FAD-dependent thymidylate synthase | 0.1667 | 0.3641 | 0.3814 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.0201 | 0.0212 |
Giardia lamblia | CDC8 | 0.0075 | 0.0044 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.425 | 0.9474 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.425 | 0.9474 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.425 | 0.9474 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.4483 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.0201 | 0.0212 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.425 | 0.9474 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.4483 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0044 | 0.0047 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 1.5849 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.