Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Homo sapiens | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | 163 aa | 133 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase IV, putative | 0.0047 | 0.3199 | 0.3199 |
Leishmania major | DNA polymerase kappa, putative | 0.0047 | 0.3199 | 0.1902 |
Giardia lamblia | DINP protein human, muc B family | 0.0047 | 0.3199 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.3199 | 0.3199 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.3199 | 0.3199 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.3199 | 0.3199 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.3199 | 0.3199 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0047 | 0.3199 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0047 | 0.3199 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0047 | 0.3199 | 0.3199 |
Echinococcus granulosus | dna polymerase kappa | 0.0047 | 0.3199 | 0.1694 |
Echinococcus multilocularis | dna polymerase eta | 0.0077 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0077 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.3199 | 0.1902 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.3199 | 0.3199 |
Trypanosoma brucei | unspecified product | 0.0047 | 0.3199 | 0.3199 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.3199 | 0.1902 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.3199 | 0.3199 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0047 | 0.3199 | 0.1694 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0047 | 0.3199 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.3199 | 0.1902 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0077 | 1 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0045 | 0.2893 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.3199 | 0.3199 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0047 | 0.3199 | 0.1694 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0047 | 0.3199 | 0.5 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0047 | 0.3199 | 0.1694 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.1811 | 0.1315 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0047 | 0.3199 | 0.1902 |
Echinococcus multilocularis | dna polymerase kappa | 0.0047 | 0.3199 | 0.1694 |
Trichomonas vaginalis | rotamase, putative | 0.004 | 0.1811 | 0.1315 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0047 | 0.3199 | 0.1694 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0047 | 0.3199 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0045 | 0.2893 | 0.1538 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.3199 | 0.3199 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0045 | 0.2893 | 0.1538 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.3199 | 0.3199 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0047 | 0.3199 | 0.1694 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0047 | 0.3199 | 0.3199 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0077 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0077 | 1 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0047 | 0.3199 | 0.1694 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0047 | 0.3199 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0047 | 0.3199 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.3199 | 0.1902 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0039 | 0.1601 | 0.1601 |
Echinococcus granulosus | dna polymerase eta | 0.0077 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.3199 | 0.3199 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.3808 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.