Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0099 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0099 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0099 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0099 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0099 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0099 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0099 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0099 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0099 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0099 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0099 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0099 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0052 | 0.1071 | 0.1071 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0099 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0099 | 1 | 1 |
Onchocerca volvulus | 0.0099 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1071 | 0.1071 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0099 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0099 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0099 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0099 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0099 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1071 | 0.1071 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0052 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0099 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0099 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0099 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0099 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0099 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0099 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0099 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0099 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0099 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0099 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0099 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0052 | 0.1071 | 0.1071 |
Brugia malayi | hypothetical protein | 0.0052 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0052 | 0.1071 | 0.1071 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0099 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0099 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0052 | 0.1071 | 0.1071 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0052 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0099 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0099 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0099 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0099 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1071 | 0.1071 |
Brugia malayi | hypothetical protein | 0.0052 | 0.1071 | 0.1071 |
Brugia malayi | nuclear hormone receptor | 0.0099 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0099 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0099 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0099 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0099 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0099 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0099 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0099 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0052 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0052 | 0.1071 | 0.1071 |
Schistosoma mansoni | nuclear hormone receptor | 0.0099 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0099 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.