Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.1273 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.2047 | 0.2047 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.3444 | 0.5334 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.1747 | 0.2527 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.1273 | 0.1273 |
Loa Loa (eye worm) | bromodomain containing protein | 0.002 | 0.1128 | 0.1128 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.1273 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0828 | 0.1199 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.1273 | 0.1971 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0019 | 0.1051 | 0.1627 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.3744 | 0.3744 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.1273 | 0.1273 |
Brugia malayi | Bromodomain containing protein | 0.0083 | 0.8397 | 0.8397 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3753 | 0.3753 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.1273 | 0.5 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.1051 | 0.152 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.1371 | 0.1983 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.1273 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.6911 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1051 | 0.1051 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0019 | 0.1051 | 0.1627 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0097 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0017 | 0.0828 | 0.1199 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.4053 | 0.4053 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.6457 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.6457 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.4296 | 0.4296 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.1273 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.7855 | 0.7855 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.3444 | 0.5334 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.1273 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.1273 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.1273 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.1273 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0019 | 0.1051 | 0.152 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.1273 | 0.1842 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.1051 | 0.152 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.1273 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.1273 | 0.1971 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.1747 | 0.2705 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0019 | 0.1051 | 0.1627 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0019 | 0.1051 | 0.152 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.1505 | 0.2177 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.1371 | 0.2123 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.1273 | 0.1842 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.1505 | 0.1505 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.1273 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.1273 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.1273 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.1273 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.1273 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.1371 | 0.2123 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0019 | 0.1051 | 0.1627 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0097 | 1 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.1747 | 0.2705 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.