Detailed information for compound 1535940

Basic information

Technical information
  • TDR Targets ID: 1535940
  • Name: N-[3-[[2-(3,4-dimethylphenoxy)acetyl]amino]pr opyl]pyridine-2-carboxamide
  • MW: 341.404 | Formula: C19H23N3O3
  • H donors: 2 H acceptors: 3 LogP: 2.56 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(COc1ccc(c(c1)C)C)NCCCNC(=O)c1ccccn1
  • InChi: 1S/C19H23N3O3/c1-14-7-8-16(12-15(14)2)25-13-18(23)21-10-5-11-22-19(24)17-6-3-4-9-20-17/h3-4,6-9,12H,5,10-11,13H2,1-2H3,(H,21,23)(H,22,24)
  • InChiKey: AEBXRGWYKCTUED-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-[[2-(3,4-dimethylphenoxy)-1-oxoethyl]amino]propyl]-2-pyridinecarboxamide
  • N-[3-[[2-(3,4-dimethylphenoxy)acetyl]amino]propyl]picolinamide
  • N-[3-[2-(3,4-dimethylphenoxy)ethanoylamino]propyl]pyridine-2-carboxamide
  • ZINC05015384
  • ASN 11412617

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0398 0.0664
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0481 0.066
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0481 0.066
Loa Loa (eye worm) RNA binding protein 0.0061 0.3226 0.4411
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0452 0.0395
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0481 0.0469
Giardia lamblia NADPH oxidoreductase, putative 0.0077 0.4268 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0452 0.0395
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.506 0.4965
Toxoplasma gondii thioredoxin reductase 0.0049 0.2396 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0481 0.0469
Brugia malayi nuclear hormone receptor 0.002 0.0481 0.066
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0481 0.0298
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.3226 0.4411
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0481 0.0298
Plasmodium falciparum thioredoxin reductase 0.0017 0.0296 0.0186
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0398 0.0201
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.2396 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0398 0.0664
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0452 0.0395
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0481 0.0643
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0019 0.0452 1
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0104 0.0143
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0256 0.0243
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0481 0.0469
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0481 0.0298
Schistosoma mansoni thyroid hormone receptor 0.002 0.0481 0.0298
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0452 0.0395
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0077 0.4268 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0189 0.0176
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0296 0.0186
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0452 0.0395
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.2364 0.3228
Giardia lamblia NADPH oxidoreductase, putative 0.0077 0.4268 1
Echinococcus granulosus lamin dm0 0.0026 0.0903 0.0892
Brugia malayi steroid hormone receptor 0.002 0.0481 0.066
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0296 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.2997 0.6801
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0452 0.0395
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0481 0.066
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0452 0.0395
Schistosoma mansoni coup transcription factor 0.002 0.0481 0.0298
Echinococcus granulosus tar DNA binding protein 0.0061 0.3226 0.3217
Brugia malayi nuclear receptor NHR-88 0.002 0.0481 0.066
Plasmodium falciparum glutathione reductase 0.0017 0.0296 0.0186
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0104 0.0125
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0296 0.0405
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0296 0.0186
Loa Loa (eye worm) hypothetical protein 0.0026 0.0872 0.118
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0481 0.0469
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0481 0.0298
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0481 0.0298
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0481 0.0469
Onchocerca volvulus 0.0026 0.0903 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0481 0.066
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0903 0.1223
Schistosoma mansoni lamin 0.0026 0.0903 0.0728
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0452 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0452 0.0395
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0296 0.0186
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0296 0.0186
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.2364 0.324
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0077 0.4268 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.6514 0.8844
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.4268 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0296 0.5
Loa Loa (eye worm) hypothetical protein 0.0015 0.0189 0.0242
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0481 0.0469
Echinococcus granulosus GPCR family 2 0.0015 0.0189 0.0176
Echinococcus multilocularis tar DNA binding protein 0.0061 0.3226 0.3217
Loa Loa (eye worm) TAR-binding protein 0.0061 0.3226 0.4411
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0256 0.0334
Brugia malayi MH2 domain containing protein 0.0123 0.7298 1
Schistosoma mansoni hypothetical protein 0.0164 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0481 0.066
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0296 0.0186
Schistosoma mansoni tar DNA-binding protein 0.0061 0.3226 0.3096
Loa Loa (eye worm) hypothetical protein 0.002 0.0481 0.0643
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0481 0.0298
Plasmodium falciparum thioredoxin reductase 0.0049 0.2396 1
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0296 0.0186
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0481 0.0643
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0452 0.0395
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0452 0.0395
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0019 0.0452 0.0395
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0481 0.0469
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0296 0.0186
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.2396 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0481 0.0469
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0452 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.4268 1
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.4268 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0452 0.0395
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0398 0.0258
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0452 0.0395
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0481 0.0643
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0452 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.4268 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0256 0.0243
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0481 0.0643
Brugia malayi isocitrate dehydrogenase 0.0016 0.0256 0.0351
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.4268 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0256 0.0243
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0019 0.0452 0.0395
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0296 0.0186
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0398 0.0258
Loa Loa (eye worm) hypothetical protein 0.002 0.0481 0.0643
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0296 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0481 0.066
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0481 0.066
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0481 0.0469
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0481 0.066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0481 0.0643
Entamoeba histolytica hypothetical protein 0.0019 0.0452 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.6514 0.8844
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0481 0.0469
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0189 0.0176
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.1357 0.186
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.3226 0.4421
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0398 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0296 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0481 0.066
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0481 0.0469
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0189 0.0259
Onchocerca volvulus 0.0026 0.0903 1
Schistosoma mansoni hypothetical protein 0.0164 1 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.2396 0.2387
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0256 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.4268 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0452 0.0395
Schistosoma mansoni ap endonuclease 0.0018 0.0398 0.0213
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.506 0.6934
Echinococcus granulosus intermediate filament protein 0.0026 0.0903 0.0892
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0296 0.0283
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0296 0.0186
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0296 0.0186
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0481 0.066
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0452 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0452 0.0395
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.2396 0.2387
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.4268 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0296 0.0056
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0296 0.0186
Plasmodium falciparum glutathione reductase 0.0049 0.2396 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0296 0.0186
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0452 0.0395
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0452 0.0395
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.7298 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.2364 0.3228
Echinococcus multilocularis lamin dm0 0.0026 0.0903 0.0892
Loa Loa (eye worm) hypothetical protein 0.002 0.0481 0.0643
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0296 0.0186
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.7298 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0398 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.6514 0.8844
Brugia malayi RNA binding protein 0.0061 0.3226 0.4421
Loa Loa (eye worm) hypothetical protein 0.002 0.0481 0.0643
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0481 0.066
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0481 0.066
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0452 0.0395
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.506 0.6929
Brugia malayi glutathione reductase 0.0049 0.2396 0.3284
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.4268 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0398 0.0664
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0452 0.0395
Brugia malayi intermediate filament protein 0.0026 0.0903 0.1238
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0296 0.0186
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0481 0.0469
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0481 0.0469
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0481 0.0298
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0481 0.0643
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0903 0.1238
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0481 0.066
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0398 0.0386
Loa Loa (eye worm) hypothetical protein 0.002 0.0481 0.0643
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.6514 0.8844
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0019 0.0452 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0452 0.0395
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0398 0.0258
Giardia lamblia NADPH oxidoreductase, putative 0.0077 0.4268 1
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0189 0.0259
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.506 0.5054
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0903 0.1223
Leishmania major trypanothione reductase 0.0049 0.2396 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0481 0.0469
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0398 0.0664
Toxoplasma gondii exonuclease III APE 0.0018 0.0398 0.0664
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.506 0.4965
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0398 0.0664
Plasmodium vivax glutathione reductase, putative 0.0049 0.2396 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0481 0.066
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0296 0.0186
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0398 0.0386
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.506 0.5054
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0256 0.0351
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0481 0.0469
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0256 0.0243
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.7332 1
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.2396 0.3272
Schistosoma mansoni nuclear hormone receptor 0.002 0.0481 0.0298
Loa Loa (eye worm) hypothetical protein 0.0026 0.0903 0.1223
Loa Loa (eye worm) hypothetical protein 0.002 0.0481 0.0643
Brugia malayi ecdysteroid receptor 0.002 0.0481 0.066
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0452 0.0395
Mycobacterium tuberculosis Probable reductase 0.0111 0.6514 0.8844
Echinococcus granulosus FTZ F1 alpha 0.002 0.0481 0.0469
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0481 0.0298
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0256 0.0068
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0189 0.0176
Loa Loa (eye worm) hypothetical protein 0.002 0.0481 0.0643
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0481 0.0298
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0452 0.0395
Echinococcus multilocularis geminin 0.0164 1 1
Schistosoma mansoni lamin 0.0026 0.0903 0.0728
Echinococcus granulosus lamin 0.0026 0.0903 0.0892
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.2396 0.3025
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.2364 0.324
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0481 0.0643
Echinococcus multilocularis lamin 0.0026 0.0903 0.0892
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.6514 0.8844
Schistosoma mansoni hypothetical protein 0.0033 0.1357 0.1191
Schistosoma mansoni tar DNA-binding protein 0.0061 0.3226 0.3096
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.4268 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.506 0.5054
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0296 0.0186
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0398 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0296 0.0283
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.7332 1
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.4268 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0481 0.0298
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0398 0.0664
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.4268 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0296 0.0186
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.506 0.4965
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0398 0.0529
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0481 0.0469
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0452 0.0395
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0296 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.4268 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.7332 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0481 0.0643
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0296 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0452 0.0395
Loa Loa (eye worm) hypothetical protein 0.0033 0.1357 0.1846
Schistosoma mansoni intermediate filament proteins 0.0026 0.0903 0.0728
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.506 0.5054
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0189 0.0242
Loa Loa (eye worm) glutathione reductase 0.0049 0.2396 0.3272
Schistosoma mansoni tar DNA-binding protein 0.0061 0.3226 0.3096
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0189 0.0176
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0256 0.0243
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0077 0.4268 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0481 0.0643
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.4268 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.3226 0.3096
Trichomonas vaginalis modulator of drug activity B, putative 0.0019 0.0452 0.0395
Echinococcus multilocularis musashi 0.0026 0.0903 0.0892
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0296 0.0186
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.7332 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0296 0.0186
Echinococcus multilocularis GPCR, family 2 0.0015 0.0189 0.0176
Schistosoma mansoni ap endonuclease 0.0018 0.0398 0.0213
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0481 0.0469
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0452 0.0395
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0481 0.066
Schistosoma mansoni tar DNA-binding protein 0.0061 0.3226 0.3096
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0019 0.0452 0.0395
Trypanosoma brucei trypanothione reductase 0.0049 0.2396 1
Brugia malayi Thioredoxin reductase 0.0049 0.2396 0.3284
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0398 0.0545
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0481 0.066
Brugia malayi TAR-binding protein 0.0061 0.3226 0.4421

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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