Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0302 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0302 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0186 | 0.5684 | 0.5684 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0267 | 0.8717 | 0.8159 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.015 | 0.4316 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0034 | 0 | 0.5 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0115 | 0.3033 | 0.3033 |
Schistosoma mansoni | diflavin oxidoreductase | 0.015 | 0.4316 | 0.4316 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0302 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0302 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0302 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.0115 | 0.3033 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0186 | 0.5684 | 0.5684 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0115 | 0.3033 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0302 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6372 | 0.6372 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0034 | 0 | 0.5 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Giardia lamblia | Hypothetical protein | 0.0267 | 0.8717 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0302 | 1 | 1 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0115 | 0.3033 | 0.3033 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0267 | 0.8717 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0115 | 0.3033 | 0.3033 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0115 | 0.3033 | 0.3033 |
Brugia malayi | flavodoxin family protein | 0.0115 | 0.3033 | 0.3033 |
Chlamydia trachomatis | sulfite reductase | 0.0186 | 0.5684 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0267 | 0.8717 | 0.8717 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.6372 | 0.6372 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6372 | 0.6372 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0302 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0115 | 0.3033 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0152 | 0.4402 | 0.4402 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0302 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0302 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0302 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0302 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0115 | 0.3033 | 0.3033 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0034 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0115 | 0.3033 | 0.3033 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0115 | 0.3033 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0302 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0302 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.015 | 0.4316 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0186 | 0.5684 | 0.5684 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0115 | 0.3033 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0302 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0302 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.6372 | 0.6372 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0302 | 1 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0186 | 0.5684 | 0.5684 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0034 | 0 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0115 | 0.3033 | 0.5 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0115 | 0.3033 | 0.3033 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0034 | 0 | 0.5 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0115 | 0.3033 | 0.3033 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0302 | 1 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0115 | 0.3033 | 0.3033 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0302 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0186 | 0.5684 | 0.5684 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0267 | 0.8717 | 0.8717 |
Leishmania major | p450 reductase, putative | 0.0302 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0302 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1458 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.122 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.