Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Bacillus subtilis (strain 168) | ATP-dependent Clp protease proteolytic subunit | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0062 | 0.3393 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.6006 | 0.5627 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4565 | 0.4565 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.6006 | 0.5 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.6006 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4565 | 0.4565 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.6006 | 0.5 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.6006 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0062 | 0.3393 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0866 | 0.5 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0094 | 0.6006 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0033 | 0.1035 | 0.0328 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0094 | 0.6006 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0033 | 0.1035 | 0.0328 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4565 | 0.4486 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3256 | 0.2617 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0094 | 0.6006 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 0.6006 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0094 | 0.6006 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 0.6006 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3256 | 0.2617 |
Brugia malayi | Probable ClpP-like protease | 0.0094 | 0.6006 | 0.6006 |
Brugia malayi | hypothetical protein | 0.003 | 0.0866 | 0.0866 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0033 | 0.1035 | 0.0328 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.6006 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4565 | 0.405 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0062 | 0.3393 | 0.4744 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4565 | 0.6633 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4565 | 0.6633 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4565 | 0.6633 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3256 | 0.3256 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4565 | 0.4486 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0094 | 0.6006 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4565 | 0.405 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4565 | 0.6633 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.6006 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4565 | 0.6633 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.6006 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4565 | 0.4565 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1727 | 0.1727 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3256 | 0.3256 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1727 | 0.0942 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4565 | 0.405 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.