Detailed information for compound 1536079

Basic information

Technical information
  • TDR Targets ID: 1536079
  • Name: N-methyl-4-phenylsulfonyl-2-thiophen-2-yl-1,3 -oxazol-5-amine
  • MW: 320.387 | Formula: C14H12N2O3S2
  • H donors: 1 H acceptors: 3 LogP: 3.71 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNc1oc(nc1S(=O)(=O)c1ccccc1)c1cccs1
  • InChi: 1S/C14H12N2O3S2/c1-15-13-14(16-12(19-13)11-8-5-9-20-11)21(17,18)10-6-3-2-4-7-10/h2-9,15H,1H3
  • InChiKey: SVSVLNHCGWVQHQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-methyl-4-phenylsulfonyl-2-(2-thienyl)oxazol-5-amine
  • N-methyl-4-phenylsulfonyl-2-(2-thienyl)-5-oxazolamine
  • methyl-[4-phenylsulfonyl-2-(2-thienyl)oxazol-5-yl]amine
  • SMR000295324
  • ZINC01052898
  • MLS000624687
  • N-methyl-4-(phenylsulfonyl)-2-(2-thienyl)-1,3-oxazol-5-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0205 0.4496 0.5347
Plasmodium vivax flavodoxin domain containing protein 0.0392 0.8833 0.875
Loa Loa (eye worm) hypothetical protein 0.0063 0.1207 0.1207
Echinococcus multilocularis sodium and chloride dependent glycine 0.0063 0.1207 0.1207
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0255 0.565 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0063 0.1207 0.1207
Brugia malayi hypothetical protein 0.0063 0.1207 0.1207
Loa Loa (eye worm) hypothetical protein 0.0293 0.6537 0.6537
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0096 0.0096
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0012 0.0013 0.0013
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0012 0.0013 0.0013
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0739 0.0739
Onchocerca volvulus 0.005 0.0901 0.1072
Mycobacterium ulcerans electron transfer protein FdxB 0.005 0.0901 0.0258
Echinococcus multilocularis serotonin transporter 0.0374 0.8408 0.8408
Trypanosoma brucei NADH-dependent fumarate reductase 0.005 0.0901 0.0258
Leishmania major cytochrome-b5 reductase, putative 0.005 0.0901 0.0258
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.066 0.066
Leishmania major NADH-dependent fumarate reductase, putative 0.005 0.0901 0.0258
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0442 1 1
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.005 0.0901 0.0258
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0169 0.3661 0.3033
Entamoeba histolytica type A flavoprotein, putative 0.0169 0.3661 0.5
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.005 0.0901 0.0258
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0043 0.0739 0.0739
Schistosoma mansoni NADPH flavin oxidoreductase 0.0223 0.4906 0.4906
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.005 0.0901 0.0258
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0169 0.3661 0.3213
Echinococcus granulosus cytochrome b5 reductase 4 0.005 0.0901 0.0901
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.005 0.0901 0.0258
Trypanosoma cruzi p450 reductase, putative 0.0442 1 1
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.005 0.0901 0.0579
Schistosoma mansoni sodium/chloride dependent transporter 0.0374 0.8408 0.8408
Toxoplasma gondii hypothetical protein 0.0063 0.1207 0.1311
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.005 0.0901 0.0258
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0012 0.0013 0.0013
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.005 0.0901 0.0258
Leishmania major NADH-cytochrome b5 reductase, putative 0.005 0.0901 0.0258
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.005 0.0901 0.0901
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0063 0.1207 0.1207
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0063 0.1207 0.1207
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0442 1 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0012 0.0013 0.0013
Giardia lamblia Nitric oxide synthase, inducible 0.0392 0.8833 1
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0096 0.0096
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0374 0.8408 0.8408
Mycobacterium tuberculosis Probable monooxygenase 0.005 0.0901 0.0483
Toxoplasma gondii flavodoxin domain-containing protein 0.022 0.4828 1
Giardia lamblia Hypothetical protein 0.0392 0.8833 1
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0169 0.3661 0.3653
Trypanosoma cruzi reductase, putative 0.005 0.0901 0.0258
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0063 0.1207 0.1207
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0063 0.1207 0.1207
Loa Loa (eye worm) beta-lactamase 0.004 0.066 0.066
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.066 0.0648
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0063 0.1207 0.1207
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.066 0.066
Mycobacterium leprae Probable lipase LipE 0.004 0.066 0.5
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.005 0.0901 0.0483
Chlamydia trachomatis sulfite reductase 0.0273 0.6073 1
Brugia malayi diaphorase 0.005 0.0901 0.0901
Loa Loa (eye worm) RasGEF domain-containing protein 0.0018 0.0163 0.0163
Loa Loa (eye worm) diaphorase 0.005 0.0901 0.0901
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0063 0.1207 0.1207
Loa Loa (eye worm) hypothetical protein 0.0063 0.1207 0.1207
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0273 0.6073 0.6073
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0034 0.0519 0.0519
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0063 0.1207 0.1207
Brugia malayi DIX domain containing protein 0.0021 0.0228 0.0228
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.005 0.0901 0.0258
Loa Loa (eye worm) hypothetical protein 0.0063 0.1207 0.1207
Onchocerca volvulus 0.004 0.066 0.0785
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.005 0.0901 0.0258
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0442 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0739 0.0739
Loa Loa (eye worm) hypothetical protein 0.0016 0.0096 0.0096
Plasmodium vivax amine transporter, putative 0.0063 0.1207 0.0585
Plasmodium vivax ferredoxin--NADP reductase, putative 0.005 0.0901 0.0258
Onchocerca volvulus 0.0374 0.8408 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0021 0.0228 0.0228
Leishmania major NADH-cytochrome b5 reductase, putative 0.005 0.0901 0.0258
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.005 0.0901 0.0258
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0012 0.0008 0.0008
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0063 0.1207 0.1311
Onchocerca volvulus 0.0063 0.1207 0.1435
Echinococcus granulosus segment polarity protein dishevelled 0.0021 0.0228 0.0228
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.005 0.0901 0.0258
Brugia malayi flavodoxin family protein 0.0169 0.3661 0.3661
Leishmania major NADH-dependent fumarate reductase-like protein 0.005 0.0901 0.0258
Entamoeba histolytica type A flavoprotein, putative 0.0169 0.3661 0.5
Leishmania major oxidoreductase-like protein 0.005 0.0901 0.0258
Onchocerca volvulus 0.004 0.066 0.0785
Plasmodium falciparum nitric oxide synthase, putative 0.0442 1 1
Loa Loa (eye worm) hypothetical protein 0.0442 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.066 0.0648
Trichomonas vaginalis esterase, putative 0.004 0.066 0.0648
Brugia malayi Cyclic-nucleotide gated cation channel 0.0012 0.0013 0.0013
Trypanosoma cruzi oxidoreductase-like protein, putative 0.005 0.0901 0.0258
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.005 0.0901 0.0483
Leishmania major nitrate reductase, putative 0.005 0.0901 0.0258
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0063 0.1207 0.1207
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0392 0.8833 0.8831
Schistosoma mansoni cytochrome P450 reductase 0.0442 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0679 0.0667
Loa Loa (eye worm) hypothetical protein 0.004 0.066 0.066
Onchocerca volvulus 0.004 0.066 0.0785
Mycobacterium leprae conserved hypothetical protein 0.004 0.066 0.5
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.005 0.0901 0.0258
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0063 0.1207 0.1207
Echinococcus multilocularis cytochrome b5 reductase 4 0.005 0.0901 0.0901
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.066 0.066
Brugia malayi beta-lactamase family protein 0.004 0.066 0.066
Mycobacterium ulcerans flavodoxin oxidoreductase 0.005 0.0901 0.0258
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.066 0.066
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.005 0.0901 0.0258
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0442 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0012 0.0013 0.0013
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0063 0.1207 0.1207
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0063 0.1207 0.1207
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0442 1 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0063 0.1207 0.1207
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0739 0.0739
Toxoplasma gondii hypothetical protein 0.0063 0.1207 0.1311
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0442 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.005 0.0901 0.0483
Schistosoma mansoni cytochrome B5 0.005 0.0901 0.0901
Loa Loa (eye worm) hypothetical protein 0.0063 0.1207 0.1207
Onchocerca volvulus 0.0063 0.1207 0.1435
Leishmania major hypothetical protein, conserved 0.0169 0.3661 0.3213
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0169 0.3661 0.3653
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.005 0.0901 0.0258
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0012 0.0013 0.0013
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0442 1 1
Trichomonas vaginalis sulfite reductase, putative 0.0442 1 1
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0063 0.1207 0.1207
Loa Loa (eye worm) hypothetical protein 0.0063 0.1207 0.1207
Trypanosoma brucei NADH-dependent fumarate reductase 0.005 0.0901 0.0258
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0169 0.3661 0.3213
Echinococcus granulosus hyperpolarization activated cyclic 0.0012 0.0013 0.0013
Plasmodium falciparum transporter, putative 0.0063 0.1207 0.0336
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.005 0.0901 0.0258
Schistosoma mansoni sodium-dependent amino acid transporter 0.0063 0.1207 0.1207
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0063 0.1207 0.1207
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0012 0.0013 0.0013
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.005 0.0901 0.0258
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0169 0.3661 0.3213
Loa Loa (eye worm) norepinephrine transporter 0.0374 0.8408 0.8408
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.066 0.066
Mycobacterium ulcerans oxidoreductase 0.005 0.0901 0.0258
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0442 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.066 0.0648
Echinococcus multilocularis hyperpolarization activated cyclic 0.0012 0.0013 0.0013
Schistosoma mansoni diflavin oxidoreductase 0.022 0.4828 0.4828
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0063 0.1207 0.1207
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0012 0.0013 0.0013
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.005 0.0901 0.0258
Loa Loa (eye worm) serotonin transporter b 0.0374 0.8408 0.8408
Schistosoma mansoni NADH-cytochrome B5 reductase 0.005 0.0901 0.0901
Entamoeba histolytica type A flavoprotein, putative 0.0169 0.3661 0.5
Leishmania major cytochrome P450 reductase, putative 0.0392 0.8833 0.875
Trypanosoma brucei oxidoreductase-protein, putative 0.005 0.0901 0.0258
Entamoeba histolytica type A flavoprotein, putative 0.0169 0.3661 0.5
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0442 1 1
Leishmania major NADH-cytochrome b5 reductase, putative 0.005 0.0901 0.0258
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.005 0.0901 0.0579
Plasmodium vivax hypothetical protein, conserved 0.0169 0.3661 0.3213
Loa Loa (eye worm) hypothetical protein 0.0021 0.0228 0.0228
Echinococcus multilocularis methionine synthase reductase 0.0273 0.6073 0.6073
Loa Loa (eye worm) flavodoxin family protein 0.0169 0.3661 0.3661
Brugia malayi beta-lactamase 0.004 0.066 0.066
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.005 0.0901 0.0901
Loa Loa (eye worm) hypothetical protein 0.0063 0.1207 0.1207
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0442 1 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.0374 0.8408 0.8408
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0063 0.1207 0.1207
Trypanosoma cruzi oxidoreductase-protein, putative 0.005 0.0901 0.0258
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0016 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0205 0.4496 0.4496
Trypanosoma brucei nitrate reductase, putative 0.005 0.0901 0.0258
Echinococcus multilocularis hyperpolarization activated cyclic 0.0012 0.0013 0.0013
Loa Loa (eye worm) DIX domain-containing protein 0.0021 0.0228 0.0228
Echinococcus multilocularis sodium and chloride dependent glycine 0.0063 0.1207 0.1207
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0169 0.3661 0.3653
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0063 0.1207 0.1207
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0442 1 1
Echinococcus granulosus segment polarity protein dishevelled 0.0021 0.0228 0.0228
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0374 0.8408 0.8408
Brugia malayi beta-lactamase family protein 0.004 0.066 0.066
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.005 0.0901 0.0258
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0012 0.0013 0.0013
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0016 0.0096 0.0096
Echinococcus multilocularis voltage gated potassium channel 0.0016 0.0096 0.0096
Echinococcus granulosus hyperpolarization activated cyclic 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.005 0.0901 0.1484
Loa Loa (eye worm) hypothetical protein 0.004 0.066 0.066
Loa Loa (eye worm) FAD binding domain-containing protein 0.0442 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.066 0.066
Loa Loa (eye worm) hypothetical protein 0.0374 0.8408 0.8408
Loa Loa (eye worm) hypothetical protein 0.0063 0.1207 0.1207
Loa Loa (eye worm) cytochrome b5 reductase 4 0.005 0.0901 0.0901
Schistosoma mansoni sodium/chloride dependent transporter 0.0063 0.1207 0.1207
Brugia malayi FAD binding domain containing protein 0.0273 0.6073 0.6073
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0063 0.1207 0.1987
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0063 0.1207 0.1311
Loa Loa (eye worm) hypothetical protein 0.004 0.066 0.066
Toxoplasma gondii flavodoxin domain-containing protein 0.022 0.4828 1
Leishmania major p450 reductase, putative 0.0442 1 1
Schistosoma mansoni dishevelled 0.0021 0.0228 0.0228
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0012 0.0013 0.0013
Schistosoma mansoni dishevelled 0.0021 0.0228 0.0228
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0021 0.0228 0.0272
Leishmania major reductase, putative 0.005 0.0901 0.0258
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0169 0.3661 0.3213
Echinococcus granulosus serotonin transporter 0.0374 0.8408 0.8408
Plasmodium vivax hypothetical protein, conserved 0.0063 0.1207 0.0585
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.005 0.0901 0.0258
Mycobacterium ulcerans flavodoxin reductase Hmp 0.005 0.0901 0.0258
Echinococcus granulosus sodium and chloride dependent glycine 0.0063 0.1207 0.1207
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0063 0.1207 0.1311
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0012 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0822 0.0822
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.005 0.0901 0.0258
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0442 1 1
Echinococcus granulosus sodium and chloride dependent glycine 0.0063 0.1207 0.1207
Mycobacterium ulcerans oxygenase 0.005 0.0901 0.0258
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0012 0.0013 0.0013
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0016 0.0096 0.0096
Echinococcus granulosus methionine synthase reductase 0.0273 0.6073 0.6073
Treponema pallidum flavodoxin 0.0169 0.3661 0.3676
Loa Loa (eye worm) hypothetical protein 0.0374 0.8408 0.8408
Entamoeba histolytica type A flavoprotein, putative 0.0169 0.3661 0.5
Onchocerca volvulus 0.0063 0.1207 0.1435
Treponema pallidum sodium- and chloride- dependent transporter 0.0374 0.8408 1
Plasmodium falciparum amino acid transporter, putative 0.0063 0.1207 0.0336
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0679 0.0667
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.005 0.0901 0.0258
Loa Loa (eye worm) FAD binding domain-containing protein 0.0273 0.6073 0.6073
Leishmania major cytochrome-b5 reductase, putative 0.005 0.0901 0.0258
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.066 0.0648
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0169 0.3661 0.3033
Trypanosoma cruzi nitrate reductase, putative 0.005 0.0901 0.0258
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.066 0.0648
Echinococcus multilocularis segment polarity protein dishevelled 0.0021 0.0228 0.0228
Trypanosoma cruzi p450 reductase, putative 0.005 0.0901 0.0258
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.005 0.0901 0.0258
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0063 0.1207 0.1207
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0442 1 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0063 0.1207 0.1207
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.005 0.0901 0.0258
Echinococcus granulosus voltage gated potassium channel 0.0016 0.0096 0.0096
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.005 0.0901 0.0258
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0169 0.3661 0.3653
Brugia malayi N-terminal motif family protein 0.0205 0.4496 0.4496
Mycobacterium ulcerans monooxygenase 0.005 0.0901 0.0258
Loa Loa (eye worm) hypothetical protein 0.004 0.066 0.066
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0442 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0012 0.0013 0.0013
Echinococcus multilocularis segment polarity protein dishevelled 0.0021 0.0228 0.0228
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0063 0.1207 0.1207
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0012 0.0013 0.0013
Brugia malayi FAD binding domain containing protein 0.0442 1 1
Brugia malayi RasGEF domain containing protein 0.0018 0.0163 0.0163
Echinococcus granulosus cytochrome b5 reductase 4 0.005 0.0901 0.0901
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.066 0.066
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.005 0.0901 0.0901
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0822 0.0822
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0063 0.1207 0.1207
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.005 0.0901 0.0258
Mycobacterium tuberculosis Possible oxygenase 0.005 0.0901 0.0483
Loa Loa (eye worm) hypothetical protein 0.004 0.066 0.066
Loa Loa (eye worm) hypothetical protein 0.0374 0.8408 0.8408

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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