Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 1 | 1 |
Schistosoma mansoni | kinase | 0.0058 | 0.2561 | 0.2561 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.5206 | 0.4519 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0039 | 0.0079 | 0.0079 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Giardia lamblia | Kinase, PLK | 0.0114 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0048 | 0.1253 | 0.1253 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0078 | 0.5206 | 0.3723 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0039 | 0 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0078 | 0.5206 | 0.1968 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0078 | 0.5206 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0078 | 0.5206 | 0.4519 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0039 | 0 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0078 | 0.5206 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0078 | 0.5206 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0048 | 0.1253 | 0.5 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0078 | 0.5206 | 0.4519 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0078 | 0.5206 | 0.4519 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0078 | 0.5206 | 0.4519 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0078 | 0.5206 | 0.5206 |
Brugia malayi | flavodoxin family protein | 0.0078 | 0.5206 | 0.4519 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0078 | 0.5206 | 0.4519 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0078 | 0.5206 | 0.4519 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0078 | 0.5206 | 0.1968 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0069 | 0.4031 | 0.2186 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.5193 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.