Detailed information for compound 1536109

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 326.393 | Formula: C18H22N4O2
  • H donors: 1 H acceptors: 3 LogP: 1.91 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)c1[nH]cnc1C(=O)N1CCc2c(C1)cccc2)CC
  • InChi: 1S/C18H22N4O2/c1-3-21(4-2)17(23)15-16(20-12-19-15)18(24)22-10-9-13-7-5-6-8-14(13)11-22/h5-8,12H,3-4,9-11H2,1-2H3,(H,19,20)
  • InChiKey: HIPKEPWWUNKFGM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax hypothetical protein, conserved 0.008 0.0555 0.1995
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0271 0.1151
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0012 0.0028 0.0117
Onchocerca volvulus 0.0032 0.0189 0.0189
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.1302 1 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0123 0.0891 0.2295
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.008 0.0555 0.456
Brugia malayi beta-lactamase family protein 0.008 0.0555 0.0555
Trichomonas vaginalis maltase-glucoamylase, putative 0.0043 0.0271 0.1151
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0078 0.0545 0.0545
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0279 0.0839
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0112 0.0801 0.0801
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0279 0.0279
Trypanosoma cruzi oligopeptidase b 0.0103 0.0736 0.2216
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.0271 0.1151
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0271 0.0816
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.008 0.0555 0.1431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0026 0.0111
Entamoeba histolytica protein kinase rad3, putative 0.0011 0.0026 0.0111
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0044 0.0279 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Brugia malayi Cytochrome P450 family protein 0.0023 0.0116 0.0116
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0368 0.2784 0.2784
Brugia malayi MH2 domain containing protein 0.0144 0.1053 0.1053
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0011 0.0026 0.0079
Mycobacterium tuberculosis Probable reductase 0.0123 0.0891 0.2295
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0269 0.2016 0.2016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.02 0.02
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0219 0.0219
Trypanosoma cruzi polo-like protein kinase, putative 0.0112 0.0801 0.2412
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0014 0.0014
Trypanosoma cruzi target of rapamycin kinase 3 0.002 0.0094 0.0283
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0028 0.0028
Mycobacterium tuberculosis Probable oxidoreductase 0.0137 0.0997 0.2569
Trypanosoma brucei prolyl oligopeptidase, putative 0.0103 0.0736 0.2216
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0368 0.2784 0.7173
Echinococcus granulosus Smad4 0.001 0.0014 0.0014
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0123 0.0891 0.2295
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0062 0.0264
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.02 0.02
Trypanosoma brucei trypanothione reductase 0.0054 0.0356 0.1071
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0368 0.2784 0.8382
Trypanosoma brucei target of rapamycin kinase 3, putative 0.002 0.0094 0.0283
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.002 0.0094 0.0399
Loa Loa (eye worm) prolyl oligopeptidase 0.0103 0.0736 0.0736
Plasmodium vivax glutathione reductase, putative 0.0054 0.0356 0.1278
Mycobacterium tuberculosis Conserved protein 0.008 0.0555 0.1431
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.1302 1 1
Trypanosoma brucei prolyl endopeptidase 0.0103 0.0736 0.2216
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Schistosoma mansoni hypothetical protein 0.0043 0.0274 0.0274
Entamoeba histolytica prolyl oligopeptidase family protein 0.0103 0.0736 0.3124
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.1396 0.5925
Schistosoma mansoni cpg binding protein 0.0034 0.0203 0.0203
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0012 0.0028 0.0028
Plasmodium vivax SET domain protein, putative 0.0034 0.02 0.0719
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0083 0.0298
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0045 0.0284 0.0284
Onchocerca volvulus Prolyl endopeptidase homolog 0.0103 0.0736 0.0736
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.1474 0.6258
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.2159 0.9167
Leishmania major isocitrate dehydrogenase, putative 0.0045 0.0284 0.0855
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.1731 0.1731
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0112 0.0801 0.0801
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0028 0.0028
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0151 0.0151
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0555 0.0555
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0062 0.0264
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0011 0.0026 0.0026
Echinococcus granulosus acylamino acid releasing enzyme 0.0103 0.0736 0.0736
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0151 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0026 0.0111
Schistosoma mansoni alpha-glucosidase 0.0167 0.1229 0.1229
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 0.2355 1
Plasmodium falciparum peptidase, putative 0.0103 0.0736 0.2643
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0269 0.2016 0.2016
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.7507 0.7507
Trypanosoma cruzi hypothetical protein, conserved 0.0103 0.0736 0.2216
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0438 0.3321 0.3321
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0438 0.3321 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.002 0.0094 0.0399
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0269 0.2016 0.2016
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0103 0.0736 0.3124
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.002 0.0094 0.0283
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.002 0.0094 0.0283
Echinococcus multilocularis geminin 0.0382 0.2891 0.2891
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0103 0.0736 0.3124
Mycobacterium ulcerans hypothetical protein 0.008 0.0555 0.456
Echinococcus multilocularis lysosomal alpha glucosidase 0.0194 0.1438 0.1438
Brugia malayi prolyl oligopeptidase family protein 0.0103 0.0736 0.0736
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.0152 0.0458
Echinococcus granulosus beta LACTamase domain containing family member 0.008 0.0555 0.0555
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0083 0.0298
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0279 0.0279
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.1396 0.5925
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0012 0.0028 0.0028
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0083 0.025
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.2159 0.9167
Leishmania major alpha glucosidase II subunit, putative 0.0043 0.0271 0.0816
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0045 0.0284 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0269 0.2016 0.2016
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0219 0.0219
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0062 0.0264
Echinococcus granulosus expressed protein 0.0012 0.0028 0.0028
Leishmania major trypanothione reductase 0.0054 0.0356 0.1071
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0083 0.025
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0271 0.1151
Entamoeba histolytica hypothetical protein 0.0028 0.0152 0.0645
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0115 0.0826 0.0826
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0012 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0028
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0244 0.0628
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0271 0.1151
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.1396 0.5925
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0274 0.0824
Mycobacterium leprae conserved hypothetical protein 0.008 0.0555 0.3251
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0028 0.0028
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.008 0.0555 0.0555
Schistosoma mansoni lamin 0.0027 0.0151 0.0151
Echinococcus granulosus lamin 0.0027 0.0151 0.0151
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0287 0.2159 0.2159
Schistosoma mansoni hypothetical protein 0.0036 0.0219 0.0219
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0368 0.2784 0.2784
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0356 0.1278
Onchocerca volvulus Glucosylceramidase homolog 0.0189 0.1396 0.1396
Echinococcus granulosus lysosomal alpha glucosidase 0.0194 0.1438 0.1438
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0356 0.1071
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0083 0.0298
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0269 0.2016 0.2016
Echinococcus multilocularis prolyl endopeptidase 0.0103 0.0736 0.0736
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0062 0.0264
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0555 0.1672
Echinococcus multilocularis expressed protein 0.0012 0.0028 0.0028
Schistosoma mansoni cpg binding protein 0.0034 0.0203 0.0203
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0103 0.0736 0.541
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.0037
Brugia malayi Glycosyl hydrolases family 31 protein 0.0043 0.0271 0.0271
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.1474 0.6258
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0026
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.002 0.0094 0.0094
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0555 0.2358
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0123 0.0891 0.7264
Brugia malayi hypothetical protein 0.0335 0.2524 0.2524
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0356 0.0356
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0028 0.0028
Onchocerca volvulus 0.008 0.0555 0.0555
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0014 0.0014
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0368 0.2784 0.8382
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0274 0.0274
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Loa Loa (eye worm) hypothetical protein 0.0045 0.0284 0.0284
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.1396 0.5925
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.0152 0.0152
Mycobacterium tuberculosis Probable hydrolase 0.008 0.0555 0.1431
Giardia lamblia Kinase, PLK 0.0112 0.0801 0.3401
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0024 0.0024
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0025 0.0025
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0438 0.3321 0.3321
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0153 0.1119 0.2884
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.002 0.0094 0.0283
Schistosoma mansoni hypothetical protein 0.0036 0.0219 0.0219
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0045 0.0284 0.1206
Entamoeba histolytica prolyl oligopeptidase family protein 0.0103 0.0736 0.3124
Echinococcus granulosus prolyl endopeptidase 0.0103 0.0736 0.0736
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0313 0.2355 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0025 0.0025
Mycobacterium tuberculosis Probable lipase LipD 0.008 0.0555 0.1431
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0116 0.0116
Mycobacterium tuberculosis Possible penicillin-binding protein 0.051 0.3881 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0011 0.0026 0.0111
Loa Loa (eye worm) G protein alpha subunit 3 0.0012 0.0028 0.0028
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0045 0.0284 0.1939
Toxoplasma gondii isocitrate dehydrogenase 0.0368 0.2784 0.8382
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0083 0.025
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0244 0.0244
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0244 0.0244
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0044 0.0279 0.1183
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.02 0.02
Trichomonas vaginalis sucrase-isomaltase, putative 0.0043 0.0271 0.1151
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0123 0.0891 0.2295
Loa Loa (eye worm) hypothetical protein 0.0013 0.0041 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0012 0.0028 0.0028
Leishmania major phosphatidylinositol 3-kinase, putative 0.002 0.0094 0.0283
Entamoeba histolytica hypothetical protein 0.0043 0.0274 0.1164
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0368 0.2784 1
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0103 0.0736 0.6301
Onchocerca volvulus 0.0012 0.0028 0.0028
Onchocerca volvulus 0.008 0.0555 0.0555
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0287 0.2159 0.2159
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0062 0.0264
Brugia malayi MH1 domain containing protein 0.001 0.0014 0.0014
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.008 0.0555 0.0555
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.0094 0.0283
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0555 0.0555
Echinococcus multilocularis GPCR, family 2 0.0036 0.0219 0.0219
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0103 0.0736 0.3124
Mycobacterium tuberculosis Probable dehydrogenase 0.0123 0.0891 0.2295
Loa Loa (eye worm) hypothetical protein 0.0103 0.0736 0.0736
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0083 0.025
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0244 0.0734
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.002 0.0094 0.0283
Loa Loa (eye worm) hypothetical protein 0.0044 0.0279 0.0279
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0083 0.0352
Echinococcus multilocularis lysosomal alpha glucosidase 0.0194 0.1438 0.1438
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0269 0.2016 0.2016
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0083 0.025
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0274 0.0983
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0269 0.2016 0.2016
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.008 0.0555 0.0555
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0012 0.0028 0.0028
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0103 0.0736 0.0736
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0151 0.0151
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0028 0.0028
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.1079 0.1079
Brugia malayi Smad1 0.001 0.0014 0.0014
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0083 0.0352
Toxoplasma gondii prolyl endopeptidase 0.0103 0.0736 0.2216
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0438 0.3321 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0026 0.0111
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0368 0.2784 0.2784
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0028 0.0028
Schistosoma mansoni cpg binding protein 0.0032 0.0189 0.0189
Entamoeba histolytica hypothetical protein, conserved 0.0103 0.0736 0.3124
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0244 0.1035
Loa Loa (eye worm) beta-lactamase 0.008 0.0555 0.0555
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0438 0.3321 1
Echinococcus granulosus Dipeptidyl peptidase 9 0.0438 0.3321 0.3321
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0062 0.0264
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0083 0.025
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0246 0.0883
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0036 0.0153
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0356 0.0356
Plasmodium falciparum thioredoxin reductase 0.0054 0.0356 0.1278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0026 0.0111
Brugia malayi CXXC zinc finger family protein 0.0032 0.0189 0.0189
Schistosoma mansoni smad1 5 8 and 0.001 0.0014 0.0014
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.045 0.1354
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0194 0.1438 0.1438
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0044 0.0279 0.0839
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0244 0.1035
Brugia malayi FAT domain containing protein 0.0009 0.0006 0.0006
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0271 0.1151
Toxoplasma gondii ABC1 family protein 0.008 0.0555 0.1672
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0103 0.0736 0.1896
Treponema pallidum fructose-bisphosphate aldolase 0.0313 0.2355 1
Schistosoma mansoni smad 0.001 0.0014 0.0014
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.002 0.0094 0.0094
Trichomonas vaginalis set domain proteins, putative 0.0264 0.1978 0.8397
Brugia malayi Probable isocitrate dehydrogenase 0.0045 0.0284 0.0284
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0083 0.025
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0083 0.025
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0801 0.3401
Brugia malayi Glycosyl hydrolases family 31 protein 0.0194 0.1438 0.1438
Echinococcus multilocularis lamin 0.0027 0.0151 0.0151
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.001 0.001
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0045 0.0284 0.0284
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0137 0.0997 0.8537
Loa Loa (eye worm) hypothetical protein 0.008 0.0555 0.0555
Onchocerca volvulus 0.0012 0.0028 0.0028
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0012 0.0028 0.0117
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.1079 0.1079
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0555 0.2358
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0012 0.0028 0.0028
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0115 0.0826 0.0826
Brugia malayi Probable isocitrate dehydrogenase 0.0045 0.0284 0.0284
Trypanosoma cruzi hypothetical protein, conserved 0.0103 0.0736 0.2216
Echinococcus granulosus ubiquitin specific protease 41 0.0044 0.0279 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Schistosoma mansoni Smad4 0.001 0.0014 0.0014
Toxoplasma gondii target of rapamycin (TOR), putative 0.002 0.0094 0.0283
Leishmania major hypothetical protein, conserved 0.008 0.0555 0.1672
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0011 0.0026 0.0026
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0062 0.0264
Schistosoma mansoni hypothetical protein 0.0461 0.3501 0.3501
Echinococcus multilocularis serine protein kinase ATM 0.0028 0.0152 0.0152
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.02 0.02
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0244 0.0244
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0276 0.2069 0.2069
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0028 0.0028
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0279 0.0279
Toxoplasma gondii FATC domain-containing protein 0.0028 0.0152 0.0458
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0269 0.2016 0.2016
Echinococcus multilocularis beta LACTamase domain containing family member 0.008 0.0555 0.0555
Plasmodium falciparum glutathione reductase 0.0019 0.0083 0.0298
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0123 0.0891 0.2295
Schistosoma mansoni hypothetical protein 0.0382 0.2891 0.2891
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.001 0.001
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0044 0.0279 0.0279
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0006 0.0026
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0189 0.0189
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0083 0.0083
Trypanosoma brucei hypothetical protein, conserved 0.008 0.0555 0.1672
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0152 0.0645
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0083 0.025
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0013 0.0036 0.0109
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.02 0.0603
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0244 0.1551
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0052 0.0052
Onchocerca volvulus 0.0264 0.1978 0.1978
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0244 0.1035
Loa Loa (eye worm) Smad1 0.001 0.0014 0.0014
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0244 0.0734
Brugia malayi prolyl oligopeptidase family protein 0.0438 0.3321 0.3321
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0014 0.0014
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0028 0.0117
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.2159 0.9167
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0219 0.0219
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 0.2355 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.002 0.0094 0.0094
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.1396 0.5925
Loa Loa (eye worm) hypothetical protein 0.008 0.0555 0.0555
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.1302 1 1
Echinococcus multilocularis musashi 0.0027 0.0151 0.0151
Onchocerca volvulus 0.0027 0.0151 0.0151
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0083 0.025
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.02 0.02
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0028 0.0028
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0083 0.025
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.002 0.0094 0.0283
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0246 0.1043
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0012 0.0028 0.0028
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0438 0.3321 1
Schistosoma mansoni hypothetical protein 0.0036 0.0219 0.0219
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0365 0.1551
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0036 0.0153
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.002 0.0094 0.0094
Leishmania major phosphatidylinositol kinase related protein, putative 0.002 0.0094 0.0284
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0801 0.3401
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1053 0.1053
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0045 0.0284 0.0284
Onchocerca volvulus 0.008 0.0555 0.0555
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0438 0.3321 1
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0103 0.0736 0.2216
Schistosoma mansoni hypothetical protein 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0028
Brugia malayi Pre-SET motif family protein 0.0034 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0094 0.0094
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0028 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0036
Trypanosoma brucei polo-like protein kinase 0.0112 0.0801 0.2412
Leishmania major phosphatidylinositol 3-related kinase, putative 0.002 0.0094 0.0283
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0062 0.0264
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.2159 0.9167
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0279 0.1183
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0083 0.0352
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0083 0.0083
Echinococcus multilocularis ubiquitin specific protease 41 0.0044 0.0279 0.0279
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0083 0.025
Echinococcus multilocularis acylamino acid releasing enzyme 0.0103 0.0736 0.0736
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.002 0.0094 0.0094
Toxoplasma gondii thioredoxin reductase 0.0054 0.0356 0.1071
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0094 0.0284
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0103 0.0736 0.2216
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.002 0.0094 0.0094
Entamoeba histolytica hypothetical protein 0.0043 0.0274 0.1164
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0083 0.0214
Trypanosoma cruzi polo-like protein kinase, putative 0.0112 0.0801 0.2412
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0244 0.0875
Brugia malayi prolyl oligopeptidase family protein 0.0103 0.0736 0.0736
Brugia malayi follicle stimulating hormone receptor 0.0276 0.2069 0.2069
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.002 0.0094 0.0283
Giardia lamblia GTOR 0.002 0.0094 0.0399
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0103 0.0736 0.2216
Giardia lamblia Alanyl dipeptidyl peptidase 0.0103 0.0736 0.3124
Leishmania major oligopeptidase b 0.0103 0.0736 0.2216
Brugia malayi MH1 domain containing protein 0.001 0.0014 0.0014
Entamoeba histolytica G protein alpha subunit, putative 0.0012 0.0028 0.0117
Brugia malayi Calcitonin receptor-like protein seb-1 0.0115 0.0826 0.0826
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0801 0.3401
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0279 0.1183
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0368 0.2784 0.8382
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0271 0.1151
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0045 0.0284 0.0284
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0244 0.0244
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0045 0.0284 0.0284
Brugia malayi Pre-SET motif family protein 0.0232 0.1731 0.1731
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0271 0.1151
Loa Loa (eye worm) hypothetical protein 0.008 0.0555 0.0555
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.1047 0.1047
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0368 0.2784 0.2784
Brugia malayi serine/threonine-protein kinase plk-2 0.0112 0.0801 0.0801
Toxoplasma gondii isocitrate dehydrogenase 0.0368 0.2784 0.8382
Brugia malayi Thioredoxin reductase 0.0054 0.0356 0.0356
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0103 0.0736 0.3124
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0122 0.0368
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0045 0.0284 0.0284
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0012 0.0028 0.0028
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0274 0.0274
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0137 0.0997 0.2569
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.1396 0.5925
Mycobacterium ulcerans beta-lactamase 0.008 0.0555 0.456
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0801 0.3401
Mycobacterium tuberculosis Probable esterase LipL 0.008 0.0555 0.1431
Echinococcus granulosus cpg binding protein 0.0034 0.0203 0.0203
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0043 0.0271 0.0271
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.0271 0.1151
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0012 0.0028 0.0028
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0028 0.0028
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0028 0.0028
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0368 0.2784 0.8382
Trypanosoma cruzi prolyl endopeptidase 0.0103 0.0736 0.2216
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0027 0.0147 0.0147
Mycobacterium leprae Probable lipase LipE 0.008 0.0555 0.3251
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0365 0.1551
Schistosoma mansoni lamin 0.0027 0.0151 0.0151
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0083 0.025
Echinococcus multilocularis smad 0.001 0.0014 0.0014
Loa Loa (eye worm) acetyltransferase 0.0148 0.1079 0.1079
Echinococcus multilocularis neutral alpha glucosidase AB 0.0043 0.0271 0.0271
Echinococcus granulosus lamin dm0 0.0027 0.0151 0.0151
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0368 0.2784 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0219 0.0219
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0478 0.0478
Loa Loa (eye worm) isocitrate dehydrogenase 0.0368 0.2784 0.2784
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0112 0.0801 0.0801
Trypanosoma brucei oligopeptidase b 0.0103 0.0736 0.2216
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.002 0.0094 0.0283
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0094 0.0094
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0356 0.0917
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0014 0.0014
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0103 0.0736 0.0736
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0009 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0219 0.0219
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0083 0.0083
Schistosoma mansoni smad1 5 8 and 0.001 0.0014 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0801 0.3401
Brugia malayi prolyl oligopeptidase family protein 0.0103 0.0736 0.0736
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0083 0.025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0026 0.0111
Schistosoma mansoni smad1 5 8 and 0.001 0.0014 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 0.2355 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Entamoeba histolytica tartrate dehydrogenase, putative 0.0045 0.0284 0.1206
Echinococcus multilocularis isocitrate dehydrogenase 0.0368 0.2784 0.2784
Loa Loa (eye worm) hypothetical protein 0.0034 0.02 0.02
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0219 0.0219
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0083 0.025
Loa Loa (eye worm) prolyl oligopeptidase 0.1302 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0028
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0012 0.0028 0.0028
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0083 0.0083
Echinococcus multilocularis dnaJ subfamily B 0.0461 0.3501 0.3501
Onchocerca volvulus 0.0027 0.0151 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.2159 0.9167
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0185 0.0185
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.0545 0.0545
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0028 0.0028
Trypanosoma brucei glucosidase, putative 0.0043 0.0271 0.0816
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0012 0.0028 0.0028
Toxoplasma gondii exonuclease III APE 0.004 0.0244 0.0734
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 0.2355 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.001 0.001
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0246 0.1043
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0045 0.0284 0.0284
Giardia lamblia Alanyl dipeptidyl peptidase 0.0103 0.0736 0.3124
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0083 0.025
Plasmodium falciparum thioredoxin reductase 0.0019 0.0083 0.0298
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0083 0.025
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0062 0.0187
Loa Loa (eye worm) hypothetical protein 0.0103 0.0736 0.0736
Onchocerca volvulus 0.0034 0.02 0.02
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0028 0.0028
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0028 0.0028
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0009 0.0006 0.0006
Echinococcus multilocularis Smad4 0.001 0.0014 0.0014
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0103 0.0736 0.2216
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0028 0.0028
Mycobacterium tuberculosis Probable lipase LipE 0.008 0.0555 0.1431
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0219 0.0219
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0103 0.0736 0.0736
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0274 0.0824
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.02 0.02
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0062 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Schistosoma mansoni hypothetical protein 0.0382 0.2891 0.2891
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Treponema pallidum NADH oxidase 0.0019 0.0083 0.0352
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0041 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Giardia lamblia Fructose-bisphosphate aldolase 0.0313 0.2355 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0115 0.0826 0.0826
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0137 0.0997 0.2569
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0028 0.0152 0.0458
Onchocerca volvulus 0.0012 0.0028 0.0028
Brugia malayi beta-lactamase family protein 0.008 0.0555 0.0555
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0313 0.2355 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0062 0.0187
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0045 0.0284 0.0284
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0028 0.0028
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0012 0.0028 0.0117
Entamoeba histolytica prolyl oligopeptidase family protein 0.0103 0.0736 0.3124
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0028 0.0028
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0274 0.1162
Brugia malayi hypothetical protein 0.0012 0.0028 0.0028
Onchocerca volvulus Serine\/threonine kinase homolog 0.0112 0.0801 0.0801
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.0094 0.0283
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0801 0.3401
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0014 0.0014
Mycobacterium tuberculosis Conserved protein 0.008 0.0555 0.1431
Echinococcus granulosus GPCR family 2 0.0036 0.0219 0.0219
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0244 0.0734
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0043 0.0271 0.0816
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0012 0.0028 0.0117
Echinococcus granulosus neutral alpha glucosidase AB 0.0043 0.0271 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0026 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0279 0.1183
Loa Loa (eye worm) hypothetical protein 0.008 0.0555 0.0555
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0153 0.1119 1
Entamoeba histolytica hypothetical protein 0.0043 0.0274 0.1164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0026 0.0111
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0044 0.0279 0.0279
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 0.2355 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0244 0.7995
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0012 0.0028 0.0028
Schistosoma mansoni unc-13 (munc13) 0.0045 0.0284 0.0284
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0045 0.0045
Schistosoma mansoni isocitrate dehydrogenase 0.0045 0.0284 0.0284
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0062 0.0187
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0028 0.0028
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0028 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0801 0.0801
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0028 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.2159 0.9167
Loa Loa (eye worm) glutathione reductase 0.0054 0.0356 0.0356
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0555 0.2358
Echinococcus multilocularis cpg binding protein 0.0034 0.0203 0.0203
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0045 0.0045
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0279 0.0839
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0083 0.0298
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0555 0.2358
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0368 0.2784 0.2784
Plasmodium vivax hypothetical protein, conserved 0.0103 0.0736 0.2643
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0028 0.0117
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.1302 1 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0368 0.2784 0.2784
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0028
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0103 0.0736 0.2216
Mycobacterium tuberculosis Probable peptidase 0.0103 0.0736 0.1896
Schistosoma mansoni fkbp-rapamycin associated protein 0.0011 0.0026 0.0026
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0356 0.0356
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0103 0.0736 0.2216
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0271 0.1151
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 0.2355 1
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0555 0.1672
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0062 0.0062
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0041 0.0041
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0244 0.0875
Echinococcus granulosus smad 0.001 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0103 0.0736 0.0736
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0062 0.0264
Schistosoma mansoni ap endonuclease 0.004 0.0244 0.0244
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.1079 0.1079
Loa Loa (eye worm) hypothetical protein 0.0024 0.0122 0.0122
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0555 0.2358
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0368 0.2784 0.8382
Echinococcus multilocularis lamin dm0 0.0027 0.0151 0.0151
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 0.2355 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0083 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0062 0.0187
Brugia malayi intermediate filament protein 0.0027 0.0151 0.0151
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0028 0.0028
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0244 0.0734
Echinococcus granulosus intermediate filament protein 0.0027 0.0151 0.0151
Schistosoma mansoni kinase 0.0057 0.0377 0.0377
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0153 0.1119 1
Schistosoma mansoni alpha glucosidase 0.0043 0.0271 0.0271
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0801 0.3401
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0036 0.0219 0.0219
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0028 0.0117
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0112 0.0801 0.2412
Loa Loa (eye worm) hypothetical protein 0.0027 0.0151 0.0151
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0274 0.0274
Trypanosoma cruzi oligopeptidase b 0.0103 0.0736 0.2216
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.002 0.0094 0.0283
Entamoeba histolytica hypothetical protein 0.0043 0.0274 0.1164
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0083 0.025
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0271 0.0816
Toxoplasma gondii hypothetical protein 0.0103 0.0736 0.2216
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0736 0.3124
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0244 0.1035
Echinococcus granulosus dnaJ subfamily B 0.0461 0.3501 0.3501
Loa Loa (eye worm) hypothetical protein 0.0016 0.0062 0.0062
Brugia malayi MH2 domain containing protein 0.001 0.0014 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.1396 0.5925
Loa Loa (eye worm) hypothetical protein 0.0335 0.2524 0.2524
Brugia malayi MH2 domain containing protein 0.001 0.0014 0.0014
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0045 0.0284 0.0284
Brugia malayi glutathione reductase 0.0054 0.0356 0.0356
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.008 0.0555 0.1431
Loa Loa (eye worm) hypothetical protein 0.0078 0.0545 0.0545
Schistosoma mansoni ap endonuclease 0.004 0.0244 0.0244
Brugia malayi isocitrate dehydrogenase 0.0368 0.2784 0.2784
Brugia malayi beta-lactamase 0.008 0.0555 0.0555
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0269 0.2016 0.2016
Schistosoma mansoni alpha-glucosidase 0.0167 0.1229 0.1229
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0279 0.0279
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0012 0.0028 0.0028
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0274 0.0274
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0014 0.0014
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.001 0.001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0094 0.0094
Brugia malayi Isocitrate dehydrogenase 0.0368 0.2784 0.2784
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0014 0.0014
Schistosoma mansoni intermediate filament proteins 0.0027 0.0151 0.0151
Entamoeba histolytica serine/threonine protein kinase, putative 0.0112 0.0801 0.3401
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0438 0.3321 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1053 0.1053
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0012 0.0028 0.0028
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0044 0.0279 0.1183
Brugia malayi G-protein alpha subunit 0.0012 0.0028 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0094 0.0094
Trichomonas vaginalis esterase, putative 0.008 0.0555 0.2358
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0274 0.1162
Plasmodium falciparum glutathione reductase 0.0054 0.0356 0.1278
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0045 0.0284 0.0732
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0103 0.0736 0.0736
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0083 0.025
Echinococcus granulosus geminin 0.0382 0.2891 0.2891
Mycobacterium tuberculosis Probable conserved lipoprotein 0.008 0.0555 0.1431
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0219 0.0219
Brugia malayi hypothetical protein 0.0043 0.0274 0.0274
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0279 0.0839
Mycobacterium tuberculosis Conserved protein 0.008 0.0555 0.1431
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0094 0.0399
Mycobacterium ulcerans lipase LipD 0.008 0.0555 0.456
Onchocerca volvulus 0.0112 0.0805 0.0805
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0013 0.0036 0.0109
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0103 0.0736 0.2216
Echinococcus granulosus serine protein kinase ATM 0.0028 0.0152 0.0152
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0028 0.0117
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0313 0.2355 1
Mycobacterium ulcerans esterase/lipase LipP 0.008 0.0555 0.456
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0244 0.1035
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.002 0.0094 0.0283

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 12.9953 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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