Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0738 | 1 | 1 |
Schistosoma mansoni | neprilysin | 0.0193 | 0.1991 | 0.1991 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.7172 | 0.655 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.331 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0282 | 0.331 | 0.2767 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0738 | 1 | 1 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0738 | 1 | 1 |
Toxoplasma gondii | peptidase family M13 protein | 0.0738 | 1 | 0.5 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0282 | 0.331 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0738 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1991 | 0.1991 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0738 | 1 | 0.5 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0738 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1991 | 0.1991 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.018 | 0.1803 | 0.1803 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0248 | 0.2809 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.018 | 0.1803 | 0.1803 |
Loa Loa (eye worm) | hypothetical protein | 0.0558 | 0.736 | 0.678 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.331 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0558 | 0.736 | 0.678 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0372 | 0.4631 | 0.4631 |
Loa Loa (eye worm) | hypothetical protein | 0.0558 | 0.736 | 0.678 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0738 | 1 | 1 |
Giardia lamblia | Deoxynucleoside kinase | 0.0372 | 0.4621 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0738 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.331 | 1 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0738 | 1 | 1 |
Trypanosoma brucei | thymidine kinase | 0.0248 | 0.2809 | 0.5 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.018 | 0.1803 | 0.1803 |
Leishmania major | thymidine kinase, putative | 0.0248 | 0.2809 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1991 | 0.1991 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.331 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0372 | 0.4631 | 0.4631 |
Schistosoma mansoni | endothelin-converting enzyme-related | 0.018 | 0.1803 | 0.1803 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.331 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0545 | 0.7172 | 0.655 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.7172 | 0.655 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1991 | 0.1991 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0545 | 0.7172 | 0.655 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.018 | 0.1803 | 0.1803 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1991 | 0.1991 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0372 | 0.4631 | 0.4631 |
Loa Loa (eye worm) | hypothetical protein | 0.0558 | 0.736 | 0.678 |
Loa Loa (eye worm) | hypothetical protein | 0.0558 | 0.736 | 0.678 |
Loa Loa (eye worm) | hypothetical protein | 0.0738 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.7172 | 0.655 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0248 | 0.2809 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0282 | 0.331 | 1 |
Schistosoma mansoni | endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) | 0.018 | 0.1803 | 0.1803 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0372 | 0.4631 | 0.4631 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.331 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0282 | 0.331 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1991 | 0.1991 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.331 | 1 |
Onchocerca volvulus | 0.0366 | 0.4532 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 0.4532 | 0.3329 |
Loa Loa (eye worm) | hypothetical protein | 0.0558 | 0.736 | 0.678 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.331 | 1 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0372 | 0.4631 | 0.4631 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0193 | 0.1991 | 0.1991 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.7172 | 0.655 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0075 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.5623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.