Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysophosphatidic acid receptor 3 | Starlite/ChEMBL | References |
Homo sapiens | lysophosphatidic acid receptor 1 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 7220 nM | In vitro antagonism of LPA-evoked [35S]-GTP-gammaS binding to lysophosphatidic acid receptor 3 in HEK293T cell lines | ChEMBL. | 15125924 |
IC50 (functional) | = 7220 nM | In vitro antagonism of LPA-evoked [35S]-GTP-gammaS binding to lysophosphatidic acid receptor 3 in HEK293T cell lines | ChEMBL. | 15125924 |
IC50 (functional) | > 10000 nM | In vitro ability to antagonize LPA-evoked [35S]-GTP-gammaS binding to lysophosphatidic acid receptor 1 in HEK293T cell lines | ChEMBL. | 15125924 |
IC50 (functional) | > 10000 nM | In vitro ability to antagonize LPA-evoked [35S]-GTP-gammaS binding to lysophosphatidic acid receptor 1 in HEK293T cell lines | ChEMBL. | 15125924 |
Ki (functional) | nM | In vitro ability to antagonize LPA-evoked [35S]-GTP-gammaS binding to lysophosphatidic acid receptor 1 in HEK293T cell lines | ChEMBL. | 15125924 |
Ki (functional) | 0 nM | In vitro ability to antagonize LPA-evoked [35S]-GTP-gammaS binding to lysophosphatidic acid receptor 1 in HEK293T cell lines | ChEMBL. | 15125924 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.