Detailed information for compound 153615

Basic information

Technical information
  • TDR Targets ID: 153615
  • Name: N-[3-(2,6-dimethylpiperidin-1-yl)propyl]-2,2- bis(4-methoxynaphthalen-1-yl)acetamide
  • MW: 524.693 | Formula: C34H40N2O3
  • H donors: 1 H acceptors: 1 LogP: 7.38 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(c2c1cccc2)C(c1ccc(c2c1cccc2)OC)C(=O)NCCCN1C(C)CCCC1C
  • InChi: 1S/C34H40N2O3/c1-23-11-9-12-24(2)36(23)22-10-21-35-34(37)33(29-17-19-31(38-3)27-15-7-5-13-25(27)29)30-18-20-32(39-4)28-16-8-6-14-26(28)30/h5-8,13-20,23-24,33H,9-12,21-22H2,1-4H3,(H,35,37)
  • InChiKey: WJSFCSSZMOGVJK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[3-(2,6-dimethyl-1-piperidyl)propyl]-2,2-bis(4-methoxy-1-naphthyl)acetamide
  • N-[3-(2,6-dimethyl-1-piperidinyl)propyl]-2,2-bis(4-methoxy-1-naphthyl)acetamide
  • N-[3-(2,6-dimethylpiperidin-1-yl)propyl]-2,2-bis(4-methoxynaphthalen-1-yl)ethanamide
  • N-[3-(2,6-dimethylpiperidino)propyl]-2,2-bis(4-methoxy-1-naphthyl)acetamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Sodium channel protein type II alpha subunit Starlite/ChEMBL References
Rattus norvegicus Sodium channel alpha subunits; brain (Types I, II, III) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus multilocularis sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania braziliensis calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania infantum calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania mexicana calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania donovani calcium channel protein, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania major calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dUTP pyrophosphatase 0.0805 1 0.5
Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0805 1 0.5
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0805 1 1
Echinococcus multilocularis dUTP pyrophosphatase 0.0805 1 0.5
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0805 1 1
Loa Loa (eye worm) dUTP diphosphatase 0.0805 1 0.5
Mycobacterium leprae PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) 0.0279 0 0.5
Schistosoma mansoni deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0805 1 0.5
Plasmodium vivax deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0805 1 0.5
Wolbachia endosymbiont of Brugia malayi dUTPase 0.0805 1 1
Entamoeba histolytica hypothetical protein 0.0805 1 1
Toxoplasma gondii deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0805 1 0.5
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0805 1 1
Trichomonas vaginalis deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0805 1 0.5
Entamoeba histolytica hypothetical protein 0.0805 1 1
Mycobacterium tuberculosis Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) 0.0279 0 0.5
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0805 1 1
Mycobacterium ulcerans deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0279 0 0.5
Treponema pallidum deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) 0.0805 1 0.5
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0805 1 1
Entamoeba histolytica hypothetical protein 0.0525 0.4682 0.4682
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0805 1 1
Mycobacterium ulcerans deoxycytidine triphosphate deaminase 0.0279 0 0.5
Chlamydia trachomatis deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0805 1 1
Entamoeba histolytica hypothetical protein 0.0525 0.4682 0.4682

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 4.4 uM In vitro inhibition of veratridine induced LDH release in rat embryos ChEMBL. 8295214
IC50 (functional) = 13 uM Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel type 2 ChEMBL. 8295214
IC50 (functional) = 13 uM Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel type 2 ChEMBL. 8295214
Ki (binding) = 0.24 uM Inhibition of [3H]- batrachotoxin binding to sodium channel in rat neocortical membrane ChEMBL. 8295214
Ki (binding) = 0.24 uM Inhibition of [3H]- batrachotoxin binding to sodium channel in rat neocortical membrane ChEMBL. 8295214

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.