Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.9914 | 0.9914 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0018 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.9914 | 0.9914 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0056 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.4012 | 0.4012 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.9914 | 0.9914 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.5325 | 0.5325 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.4012 | 0.4012 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4012 | 0.4012 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.3855 | 0.3855 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0056 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0056 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0056 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0056 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0056 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.9914 | 0.9914 |
Echinococcus multilocularis | musashi | 0.0033 | 0.4012 | 0.4012 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0056 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 0.4012 | 0.5 | |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.4012 | 0.4012 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.4012 | 0.4012 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.4012 | 0.4012 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0018 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.5325 | 0.5325 |
Onchocerca volvulus | 0.0033 | 0.4012 | 0.5 | |
Schistosoma mansoni | lamin | 0.0033 | 0.4012 | 0.4012 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.5325 | 0.5325 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0056 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.4012 | 0.4012 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.4012 | 0.4012 |
Echinococcus granulosus | lamin | 0.0033 | 0.4012 | 0.4012 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.4012 | 0.4012 |
Echinococcus multilocularis | lamin | 0.0033 | 0.4012 | 0.4012 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.4012 | 0.4012 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.